Doubling up on function: dual-specificity tyrosine-regulated kinase 1A (DYRK1A) in B cell acute lymphoblastic leukemia

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

(2021) Rahul S. Bhansali et al.   JOURNAL OF CLINICAL INVESTIGATION

Outcomes in children with Down syndrome (DS) and B-lymphoblastic leukemia (B-ALL): A Children’s Oncology Group (COG) report.

(2020) Karen R. Rabin et al.   JOURNAL OF CLINICAL ONCOLOGY

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

(2020) Lucia Cabal-Hierro et al.   Nature Communications

Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0331

(2019) Kelly W. Maloney et al.   JOURNAL OF CLINICAL ONCOLOGY

Lessons from the Crypt: HMGA1—Amping up Wnt for Stem Cells and Tumor Progression

(2018) Linda Resar et al.   CANCER RESEARCH

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

(2018) Cody T. Mowery et al.   Cell Reports

Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development

(2017) T Dang et al.   MOLECULAR PSYCHIATRY

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

(2017) Lingling Xian et al.   Nature Communications

The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome

(2016) P Lee et al.   LEUKEMIA

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

(2015) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Acute Lymphoblastic Leukemia in Children

(2015) Stephen P. Hunger et al.   NEW ENGLAND JOURNAL OF MEDICINE

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

(2015) Ramzi Abbassi et al.   PHARMACOLOGY & THERAPEUTICS

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

(2014) Andrew A Lane et al.   NATURE GENETICS

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

(2013) T. D. Buitenkamp et al.   BLOOD

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

(2012) Sébastien Malinge et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group

(2012) Stephen P. Hunger et al.   JOURNAL OF CLINICAL ONCOLOGY

Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia

(2012) Stephen P. Hunger et al.   PEDIATRIC BLOOD & CANCER

HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks

(2012) Sandeep N. Shah et al.   PLoS One

Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study

(2012) Yoav H. Messinger et al.   Cancer Genetics

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

(2011) Andrew Schuldenfrei et al.   BMC GENOMICS

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY