Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the hope-combi survey

We examined the effects of a fixed-dose single-pill combination of cilnidipine (10 mg), an L-/N-type calcium channel blocker, and valsartan (80 mg) (SPC of Cil/Val) on the day-by-day variability of morning home systolic blood pressure (MHSBP) in 616 patients with treated hypertension for 12 months as a sub-analysis of the HOPE-Combi survey, multicentral, post-marketing, and prospective observational survey. The SPC of Cil/Val was administrated once a day in the morning. The SPC of Cil/Val decreased the standard deviation (SD, from 6.3 +/- 4.8 to 5.1 +/- 3.8 mmHg, p < .01), coefficient of variation (from 4.3 +/- 3.2 to 3.8 +/- 2.9%, p < .05), average real variability (ARV, from 7.9 +/- 6.6 to 6.3 +/- 5.1 mmHg, p < .01), and the difference between maximum and minimum (MMD, from 11.9 +/- 9.2 to 9.7 +/- 7.2 mmHg, p < .01) of MHSBP. The variability of MHSBP increased with age; however, this was not increased in patients >= 70 years at the baseline. In elderly patients (>= 70 years, N = 283), the SPC of Cil/Val decreased the SD (from 6.9 +/- 5.6 to 5.6 +/- 4.4 mmHg, p < .01), ARV (from 8.6 +/- 7.7 to 6.9 +/- 5.7 mmHg, p < .05), and MMD (from 13.2 +/- 10.7 to 10.7 +/- 8.3 mmHg, p < .01) of MHSBP at 12 months; the reduction in these MHSBP variability parameters was comparable to that in adults <70 years. These results suggest that the SPC of Cil/Val is effective in reducing day-by-day variability of MHSBP in elderly patients.

Automated summary

The study investigated the effects of a fixed-dose single-pill combination of cilnidipine and valsartan on the day-by-day variability of morning home systolic blood pressure in elderly patients with treated hypertension. The results showed a reduction in the variability of morning home systolic blood pressure in elderly patients, indicating the effectiveness of the combination therapy.