Ubiquitously specific protease 4 inhibitor‐Vialinin A attenuates inflammation and fibrosis in S100‐induced hepatitis mice through Rheb/mTOR signalling

USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling

(2019) Jiangqiao Zhou et al.   CLINICAL SCIENCE

Review article: unanswered clinical and research questions in autoimmune hepatitis-conclusions of the International Autoimmune Hepatitis Group Research Workshop

(2019) Jessica K. Dyson et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice

(2019) Chin-Chuan Chen et al.   Translational Research

microRNA‐143‐3p attenuated development of hepatic fibrosis in autoimmune hepatitis through regulation of TAK1 phosphorylation

(2019) Hanxiao Tu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular and Molecular Mechanisms of Autoimmune Hepatitis

(2018) G.J. Webb et al.   Annual Review of Pathology-Mechanisms of Disease

High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier

(2018) En-De Hu et al.   CELLULAR IMMUNOLOGY

Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease

(2018) Yichao Zhao et al.   HEPATOLOGY

Up-regulated deubiquitinase USP4 plays an oncogenic role in melanoma

(2018) Weinan Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

(2018) Lu Chen et al.   MOLECULAR IMMUNOLOGY

Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo

(2018) Himangshu Sonowal et al.   Oxidative Medicine and Cellular Longevity

Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression via cyclophilin A stabilization and deubiquitination

(2018) Tianyi Li et al.   Cell Death & Disease

Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition

(2018) Chan Qiu et al.   Aging-US

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

(2018) Lu Deng et al.   CELL RESEARCH

Exercise ameliorates insulin resistance via regulating TGFβ-activated kinase 1 (TAK1)-mediated insulin signaling in liver of high-fat diet-induced obese rats

(2018) Yong Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin inhibits mTOR-HIF-1α axis and profibrogenic and inflammatory biomarkers in thioacetamide-induced hepatic tissue alterations

(2018) Fahaid Al-Hashem et al.   JOURNAL OF CELLULAR PHYSIOLOGY

H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes

(2018) Jie Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Grand round: Autoimmune hepatitis

(2018) Palak J. Trivedi et al.   JOURNAL OF HEPATOLOGY

The ubiquitin–proteasome system and its potential application in hepatocellular carcinoma therapy

(2016) Yan-Jie Chen et al.   CANCER LETTERS

Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin

(2016) Hongbo Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EASL Clinical Practice Guidelines: Autoimmune hepatitis

(2015)   JOURNAL OF HEPATOLOGY

Cutting Edge: Ubiquitin-Specific Protease 4 Promotes Th17 Cell Function under Inflammation by Deubiquitinating and Stabilizing RORγt

(2015) Jing Yang et al.   JOURNAL OF IMMUNOLOGY

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

(2015) Z Li et al.   ONCOGENE

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Vialinin A is a ubiquitin-specific peptidase inhibitor

(2013) Kiyoshi Okada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells

(2012) Jun-ichi Onose et al.   CELLULAR IMMUNOLOGY