Review
Biochemistry & Molecular Biology
Shusuke Toden, Timothy J. Zumwalt, Ajay Goel
Summary: Recent advances have highlighted the importance of non-coding RNAs, particularly microRNAs, in cancer pathogenesis. These ncRNAs have shown potential for therapeutic development in cancer, with early data from pre-clinical studies demonstrating promising results in human trials. While miRNAs have been extensively studied, there is ongoing research to uncover the molecular mechanisms and therapeutic targets of other lesser studied ncRNAs in cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Maryam Kay, Bahram M. Soltani, Mohamed Nemir, Parisa Aghagolzadeh, Iole Pezzuto, Panagiotis Chouvardas, Francesco Ruberto, Fatemeh Movahedi, Hassan Ansari, Hossein Baharvand, Thierry Pedrazzini
Summary: This study identified a conserved lncRNA named CARMA that regulates cardiomyocyte differentiation and maturation in human ESCs. CARMA is closely linked to the host gene MIR-1-1HG, which produces two cardiogenic miRNAs. The study suggests the involvement of a network of three newly identified lncRNAs, two miRNAs, and the NOTCH signaling pathway in the coordinated regulation of cardiogenic differentiation in ESCs.
CARDIOVASCULAR RESEARCH
(2022)
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Article
Cell & Tissue Engineering
Sara Reis Moura, Jaime Freitas, Claudia Ribeiro-Machado, Jorge Lopes, Nuno Neves, Helena Canhao, Ana Maria Rodrigues, Mario Adolfo Barbosa, Maria Ines Almeida
Summary: This study decodes the regulatory network of the lncRNA H19 on the extracellular matrix (ECM) and reveals its impact on bone regeneration. Inhibition of H19 expression results in decreased ECM density and collagen content, and promotes adipogenic differentiation of bone marrow-derived stem cells. Furthermore, H19 is targeted by miR-29c, which is downregulated in osteoporotic bone tissue and affects MSC proliferation and collagen production. These findings suggest that H19 is a potential therapeutic target for controlling cell behavior and engineering the bone ECM.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Aurilia, Simone Donati, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Tumors of the parathyroid glands are common endocrine diseases characterized by parathyroid hormone hypersecretion, with a wide range of clinical presentations and typically treated through surgical removal. Recent studies have suggested that alterations to the epigenetic mechanisms could play a pivotal role in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Sara Fadaei, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, Hamed Mirzaei
Summary: Myocardial infarction (MI) is a leading cause of global deaths. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), have been found to regulate pathological processes in MI, and exosomal ncRNAs have been shown to play important roles in cell communication and disease development. Therefore, understanding the role of ncRNAs and exosomal ncRNAs in MI is of great significance for diagnosis and prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Correction
Cell Biology
Luisa Statello, Chun-Jie Guo, Ling-Ling Chen, Maite Huarte
Summary: A correction to this paper has been published at the specified link.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yuhong Zeng, Na Wu, Zhihui Zhang, Li Zhong, Guowei Li, Yafei Li
Summary: Arrhythmias are characterized by heart rate disturbances and rhythm abnormalities, leading to significant morbidity and mortality. Current treatments lack effectiveness and often have adverse effects due to limited understanding of the pathological mechanism. Non-coding RNAs have been shown to be involved in arrhythmias and offer potential for new therapeutic targets. This review focuses primarily on atrial fibrillation (AF), the most common arrhythmia, to provide insight into the mechanistic role of non-coding RNAs and facilitate the development of targeted therapies.
Review
Cell Biology
Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Non-coding RNAs play a crucial role in regulating angiogenesis in glioblastoma, affecting gene transcription and the expression of angiogenesis-inducing molecules through various mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Maliheh Entezari, Afshin Taheriazam, Sima Orouei, Shayan Fallah, Arezoo Sanaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Shamin Rezaei, Hajar Heidari, Mitra Behroozaghdam, Salman Daneshi, Shokooh Salimimoghadam, Sepideh Mirzaei, Mehrdad Hashemi, Saeed Samarghandian
Summary: The lncRNA-miRNA axis plays a critical role in cancer initiation, development, and therapy resistance by regulating tumor metastasis, cell death mechanisms, and sensitivity of tumor cells to treatment. It is also involved in the regulation of other signaling networks and can serve as a diagnostic and prognostic marker in cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pathology
Neda Rahimian, Amirhossein Sheida, Mohammadreza Rajabi, Mohammad Mahdi Heidari, Mohammad Tobeiha, Pegah Veradi Esfahani, Sahar Ahmadi Asouri, Michael R. Hamblin, Omid Mohamadzadeh, Alireza Motamedzadeh, Mahmood Khaksary Mahabady
Summary: Pituitary adenoma is the third most common primary intracranial tumor and often diagnosed at an advanced stage. Non-coding RNAs could serve as potential biomarkers for earlier identification and better management of the disease. This review discusses the dysregulated expression patterns of different types of ncRNAs and their potential molecular pathways in Pituitary adenoma.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Plant Sciences
Baibhav Kumar, Bibek Saha, Sarika Jaiswal, U. B. Angadi, Anil Rai, Mir Asif Iquebal
Summary: This study identified and characterized 6406 long non-coding RNAs (lncRNAs) and 4621 circular RNAs (circRNAs) in black pepper through RNA-Seq analysis. These lncRNAs were found to regulate 781 black pepper genes/gene products via miRNA-lncRNA-mRNA network interactions, functioning as competitive endogenous RNAs (ceRNAs). Additionally, 35 lncRNAs were identified as potential precursors of 94 miRNAs. These findings provide valuable insights into yield regulation and stress responses in black pepper for improved breeding programs.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Oncology
Tanchun Cheng, Shouguo Huang
Summary: Metastasis in cervical cancer is not well understood, with non-coding RNAs playing diverse roles in this process. Dysregulation of miRNAs, lncRNAs, and circRNAs is associated with metastasis. They regulate metastasis by influencing metastasis-related genes, epithelial-mesenchymal transition, signaling pathways, and interactions with the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratico
Summary: Non-protein-coding RNAs have been found to play significant roles in neurodegenerative disorders such as Alzheimer's disease, affecting gene expression, amyloid-beta production, and other key mechanisms underlying disease pathology.
AGEING RESEARCH REVIEWS
(2021)
Letter
Cardiac & Cardiovascular Systems
Tian Liang, Feng Gao, Jun Jiang, Yao Wei Lu, Feng Zhang, Yingchao Wang, Ning Liu, Xuyang Fu, Xiaoxuan Dong, Jianqiu Pei, Douglas B. Cowan, Xinyang Hu, Jian'an Wang, Da-Zhi Wang, Jinghai Chen
Article
Biotechnology & Applied Microbiology
Xin He, Jianming Liu, Fei Gu, Jinghai Chen, Yao Wei Lu, Jian Ding, Haipeng Guo, Mao Nie, Masaharu Kataoka, Zhiqiang Lin, Xiaoyun Hu, Huaqun Chen, Xinxue Liao, Yugang Dong, Wang Min, Zhong-Liang Deng, William T. Pu, Zhan-Peng Huang, Da-Zhi Wang
Summary: In this study, it was discovered that CIP protein participates in the regulation of dystrophic cardiomyopathy in Duchenne muscular dystrophy (DMD) patients. Deletion of CIP led to dilated cardiomyopathy and heart failure in young mdx mice, while overexpression of CIP reduced pathological dystrophic cardiomyopathy in old mdx mice. Transcriptome analyses revealed that fibrogenesis and oxidative stress pathways were affected by CIP, and suppression of the CnA-NFAT pathway resulted in decreased expression of Nox4, a key component in the oxidative stress pathway. Overexpression of Nox4 accelerated the development of dystrophic cardiomyopathy in mdx mice. Hence, CIP could serve as a modifier and potential therapeutic target for dystrophic cardiomyopathy.
Review
Cell Biology
Yi Wang, Jinghai Chen, Douglas B. Cowan, Da-Zhi Wang
Summary: In the past two decades, ncRNAs, especially miRNAs, lncRNAs, and circRNAs, have been found to play important roles in ischemic heart disease, participating in the process of cardiac recovery. Studies have shown that at least five miRNAs have therapeutic potential in large animal models, with favorable outcomes. Furthermore, the functional roles of lncRNAs and circRNAs are also being explored in cardiac regeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
