Article
Biochemistry & Molecular Biology
Adam D. Morris, Daniel L. D. Freitas, Kassio M. G. Lima, Lauren Floyd, Mark E. Brady, Ajay P. Dhaygude, Anthony W. Rowbottom, Francis L. Martin
Summary: This study evaluated the application of machine learning and Raman spectroscopy for the automated computational detection of disease activity in ANCA-associated glomerulonephritis. The results showed that spectral data from tissue samples were able to accurately discriminate disease activity, while corresponding spectrochemical changes in paired urine samples were limited.
Article
Immunology
Florian G. Scurt, K. Bose, Ben Hammoud, S. Brandt, A. Bernhardt, C. Gross, Peter R. Mertens, Christos Chatzikyrkou
Summary: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis is a severe multisystem disease that relies on clinical judgment for treatment. There are still many unknowns in the pathogenesis and management of this disease. In recent years, new molecules have been explored to improve treatment outcomes and reduce complications.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Matic Bosnjak, Zeljka Veceric-Haler, Emanuela Bostjancic, Nika Kojc
Summary: This study aims to identify the intrarenal miRNA expression profile in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) patients and explore potential candidate-specific miRNAs. Analysis revealed 17 miRNAs that can differentiate AAV patients from healthy and inflammatory controls, some of which are related to cytokines involved in AAV pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Luca Quartuccio, Elena Treppo, Livio Urso, Giulia Del Frate, Federica Mescia, Federico Alberici, Augusto Vaglio, Giacomo Emmi
Summary: In recent years, there has been significant progress in clinical research and treatments for ANCA-associated vasculitis. However, there are still unanswered questions and unmet needs regarding AAV patients, such as predicting relapse and improving quality of life. Identifying predictors of relapse can optimize therapies and reduce side effects, while recognizing the long-term consequences of the disease and its treatment is crucial. This review aims to highlight achievements, challenges, and the perspectives of physicians and patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Mats L. Junek, Lily Zhao, Stephanie Garner, David Cuthbertson, Christian Pagnoux, Curry L. Koening, Carol A. Langford, Carol A. McAlear, Paul A. Monach, Larry W. Moreland, Rennie L. Rhee, Philip Seo, Ulrich Specks, Antoine G. Sreih, Kenneth Warrington, Michael E. Wechsler, Peter A. Merkel, Nader A. Khalidi
Summary: This study analyzed data from AAV patients between 2006 and 2022, and found that ocular manifestations occur in 23.1% of AAV patients, with GPA being the most common form. The most common ocular diseases are conjunctivitis/episcleritis and scleritis. Ocular complications include cataracts and visual impairment. Clinicians should be aware of the wide spectrum of ocular diseases in AAV patients.
Review
Medicine, General & Internal
Salem Almaani, Lynn A. Fussner, Sergey Brodsky, Alexa S. Meara, David Jayne
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. AAV involves multiple organ systems clinically, including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has significantly improved due to advances in understanding its pathogenesis and treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Laura Perray, Yann Nguyen, Gaelle Clavel Refregiers, Thibaud Chazal, Emmanuel Heron, Clara Pouchelon, Bertrand Dunogue, Nathalie Costedoat-Chalumeau, Anne Murarasu, Alexis Regent, Xavier Puechal, Benjamin Thoreau, Francois Lifermann, Julie Graveleau, Miguel Hie, Antoine Froissart, Antoine Baudet, Alban Deroux, Christian Lavigne, Sebastien Puigrenier, Rafik Mesbah, Thomas Moulinet, Claire Vasco, Sabine Revuz, Gregory Pugnet, Virginie Rieu, Anais Combes, Antoine Brezin, Benjamin Terrier
Summary: This retrospective case-control study compares the characteristics, treatment, and outcome of isolated ANCA-associated scleritis and idiopathic scleritis with negative ANCA tests. The study found that isolated ANCA-associated scleritis is more common in females and often requires systemic treatment with poorer efficacy. Furthermore, 30.7% of patients with ANCA-associated scleritis progressed to systemic ANCA-associated vasculitis. This highlights the importance of ANCA testing in the diagnosis and treatment of scleritis.
Article
Rheumatology
Brett Doliner, Karen Rodriguez, Sydney B. Montesi, Xiaoqing Fu, Amita Sharma, Zachary S. Wallace
Summary: ILD is a common complication of AAV, especially among MPO-ANCA+ AAV patients, often preceding the diagnosis of AAV. Fibrotic AAV-ILD is associated with a higher risk of death compared to AAV patients without ILD.
Article
Immunology
Desiree Tampe, Peter Korsten, Philipp Stroebel, Samy Hakroush, Bjoern Tampe
Summary: This study systematically analyzed sex differences in patients with AAV and biopsy-proven ANCA GN, finding that female patients presented at an older age with more joint involvement and exhibited specific sex differences in laboratory parameters and histopathological findings. There were fewer associations between clinical, laboratory parameters, and histopathological findings in females compared to males, indicating the importance of considering sex differences in AAV, particularly ANCA GN.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Janina Mueller-Deile, Christian Jaremenko, Hermann Haller, Mario Schiffer, Marion Haubitz, Silke Christiansen, Christine Falk, Lena Schiffer
Summary: Distinct cytokine patterns were identified for renal manifestation and ear, nose, and throat involvement in PR3-AAV. Plasma cytokines may serve as non-invasive biomarkers for organ involvement in AAV.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
David R. W. Jayne, Peter A. Merkel, Thomas J. Schall, Pirow Bekker
Summary: In this study, the C5a receptor inhibitor avacopan was found to be noninferior to prednisone taper in achieving remission at week 26, but superior in achieving sustained remission at week 52 in patients with ANCA-associated vasculitis. All patients received cyclophosphamide or rituximab. The safety and clinical effects of avacopan beyond 52 weeks were not addressed in the trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Vladimir Tesar, Zdenka Hruskova
Summary: The alternative complement pathway plays an important role in the treatment of AAV. Avacopan shows similar efficacy and better safety compared to high-dose corticosteroids in the induction treatment of AAV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sha-sha Chen, Hao-jun Luo, Huan Li, Hong Zhang, Yuan-yuan Li, Yi Li, Wei Wang, Han-lu Ding
Summary: This study found that plasma FXII levels are positively correlated with disease activity and histologic activity in AAV, and may serve as markers for active AAV.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Shogo Matsuda, Takuya Kotani, Reiko Wakura, Takayasu Suzuka, Hiroko Kuwabara, Takao Kiboshi, Yumiko Wada, Hideyuki Shiba, Kenichiro Hata, Takeshi Shoda, Yoshinobu Hirose, Tohru Takeuchi
Summary: The study found that nailfold videocapillaroscopy (NVC) is a useful tool for assessing the disease activity and treatment response in ANCA-associated vasculitis (AAV).
Review
Immunology
Wen-Man Zhao, Zhi-Juan Wang, Rui Shi, Yu-Yu Zhu, Sen Zhang, Rui-Feng Wang, De-Guang Wang
Summary: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of diseases characterized by inflammation and destruction of small and medium-sized blood vessels. Environmental factors such as silica exposure and air pollution are risk factors for AAV. This review summarizes the recent literature on the study of environmental factors, including seasonal variations, air pollution, latitude, silica, and microbial infection, in AAV, aiming to explore their relationship and possible mechanisms of action.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Marfran C. D. Santos, Jorge L. S. Viana, Joelma D. Monteiro, Renato C. M. Freire, Daniel L. D. Freitas, Ingrid M. Camara, Gigliane J. S. da Silva, Renata A. Gama, Joselio M. G. Araujo, Kassio M. G. Lima
Summary: Entomological surveillance is one of the most important steps in preventing arboviruses. This study used near infrared (NIR) and mid infrared (MIR) spectra to build chemometric models that can differentiate between dengue-infected and non-infected Aedes aegypti mosquitoes. The models based on NIR spectra and Genetic Algorithm (GA) achieved better classification results. The findings have important applications in the field of entomological surveillance and prevention of dengue vectors.
Article
Parasitology
Hellyda K. T. de Andrade Silva, Taciano M. Barbosa, Marfran C. D. Santos, Lidiane G. Silva, Leomir A. S. de Lima, Camilo L. M. Morais, Tatiana C. Bicudo, Renata A. Gama, Kassio M. G. Lima
Summary: This study evaluated the use of near infrared spectroscopy (NIRS) and chemometric methods to separate fly specimens into taxonomic categories and understand their taxonomic relationship. The results showed that NIRS is efficient in identifying the family and genera of flies, providing quick evidence for species identification.
Article
Biochemical Research Methods
Anne B. F. Camara, Wellington J. O. da Silva, Heloise O. M. A. Moura, Natanny K. N. Silva, Kassio M. G. de Lima, Luciene S. de Carvalho
Summary: This research successfully detected and quantified the contamination of kerosene solvent in private aircraft jet fuel using a chemometric methodology combined with spectroscopic techniques, and developed a fast, low-cost, and efficient process for quality control.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Parasitology
Hellyda K. T. de Andrade Silva, Taciano M. Barbosa, Marfran C. D. Santos, Jessica T. Jales, Antonio M. U. de Araujo, Camilo L. M. Morais, Leomir A. S. de Lima, Tatiana C. Bicudo, Renata A. Gama, Pablo Alves Marinho, Kassio M. G. Lima
Summary: The study used attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to detect toxic substances in fly larvae from decomposing carcasses, which can assist criminal experts in determining the cause of death in suspected poisoning cases.
Review
Instruments & Instrumentation
Ricardo Fernandes dos Santos, Maria Paraskevaidi, Kassio M. G. Lima
Summary: One of the biggest challenges in Alzheimer's disease (AD) diagnosis is the development of high-performance and minimally invasive tools that can be used in real-time. Biospectroscopic techniques coupled with chemometrics have shown potential in identifying pathological changes in AD before symptoms appear.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Medicine, General & Internal
Emma L. Callery, Camilo L. M. Morais, Lucy Nugent, Anthony W. Rowbottom
Summary: The aim of this study is to explore the potential of using Raman spectroscopy as a diagnostic platform for systemic lupus erythematosus (SLE). By analyzing Raman signatures in serum samples, the study successfully differentiated SLE patients from healthy controls. The results demonstrated excellent performance characteristics of Raman spectroscopy, setting the foundations for future translation into clinical practice.
Article
Multidisciplinary Sciences
Tales Gomes da Silva, Camilo L. M. Morais, Marfran C. D. Santos, Leomir A. S. de Lima, Raysa Vanessa de Medeiros Freitas, Ricardo Oliveira Guerra, Kassio M. G. Lima
Summary: This study used mid-infrared spectroscopy combined with chemometric techniques to identify osteosarcopenia based on blood serum samples. The results showed that the infrared spectroscopy of blood samples has the potential to identify osteosarcopenia in a simple, fast, and objective way.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Marcelo V. S. Alves, Lanaia I. L. Maciel, Joao O. S. Passos, Camilo L. M. Morais, Marfran C. D. dos Santos, Leomir A. S. Lima, Boniek G. Vaz, Rodrigo Pegado, Kassio M. G. Lima
Summary: This study chemically analyzed blood plasma samples from patients with and without fibromyalgia, combined with symptoms used in the diagnosis of this disease. Spectral data were organized into datasets and submitted to multivariate classification, resulting in good discrimination between controls and fibromyalgia samples. The results confirmed the technique as a good analytical tool for fibromyalgia detection and provided theoretical support for further studies on fibromyalgia diagnosis.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Francis L. Martin, Camilo L. M. Morais, Andrew W. Dickinson, Tarek Saba, Thomas Bongers, Maneesh N. Singh, Danielle Bury
Summary: Saliva can be used as a liquid biopsy for screening lung cancer and prostate cancer. By analyzing the bioconstituents in saliva samples using infrared spectroscopy and principal component analysis, a highly accurate model can be built for the detection of these cancers in primary care settings.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Ishaan Maitra, Camilo L. M. Morais, Kassio M. G. Lima, Katherine M. Ashton, Danielle Bury, Ravindra S. Date, Francis L. Martin
Summary: This study demonstrates the potential of ATR-FTIR spectroscopy in classifying and differentiating different stages of oesophageal transformation to oesophageal adenocarcinoma. The study used various algorithms for variable selection and classification, with PCA-QDA showing the highest accuracy in classification. The findings highlight the importance of further research in identifying biochemical markers for early detection of neoplastic changes in susceptible epithelium.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Analytical
Weiyi Pang, Yu Xing, Camilo L. M. Morais, Qiufeng Lao, Shengle Li, Zipeng Qiao, You Li, Maneesh N. Singh, Valerio G. Barauna, Francis L. Martin, Zhiyong Zhang
Summary: Diabetes mellitus (DM) is a metabolic disease that is of increasing global concern. The diagnosis and detection of DM and pre-diabetes are currently complicated, expensive, and time-consuming. In this study, a discriminant model was developed using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy combined with principal component analysis linear discriminant analysis (PCA-LDA), which resulted in a high accuracy rate of 97% for diagnosing DM and pre-diabetes. This approach has significant clinical implications for intervention and risk reduction.
Article
Oncology
Alexandros Laios, Daniel Lucas Dantas De Freitas, Gwendolyn Saalmink, Yong Sheng Tan, Racheal Johnson, Albina Zubayraeva, Sarika Munot, Richard Hutson, Amudha Thangavelu, Tim Broadhead, David Nugent, Evangelos Kalampokis, Kassio Michell Gomes de Lima, Georgios Theophilou, Diederick De Jong
Summary: This study developed a novel predictive LOS score based on artificial intelligence for advanced-stage high-grade serous ovarian cancer patients following cytoreductive surgery. By using machine learning and deep learning methods, key factors affecting LOS were accurately identified.