Article
Polymer Science
Lukas P. Sadowski, Andrew Singh, Daniel H. Luo, Michael J. Majcher, Ivan Urosev, Meghan Rothenbroker, Vitaliy Kapishon, Niels M. B. Smeets, Todd Hoare
Summary: In this study, brush co-polymer analogues were synthesized via atom transfer radical polymerization (ATRP) and used to fabricate nanoparticles for drug delivery applications. These analogues exhibited high colloidal stability, favorable in vitro cytocompatibility, and effective drug loading. The functionalization of the hydrophobic block allowed for controlled release of the nanoparticles.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Kohei Sano, Koki Umemoto, Haruka Miura, Satoshi Ohno, Kyohei Iwata, Rin Kawakami, Masayuki Munekane, Toshihide Yamasaki, Daniel Citterio, Yuki Hiruta, Takahiro Mukai
Summary: Poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) was investigated as a potential drug carrier for tumor diagnosis. Different derivatives of POEGMA with varying molecular weights and side chain lengths were synthesized and labeled with radioisotopes or fluorescence dyes. The results showed that the POEGMA derivatives were efficiently taken up by tumor cells and exhibited high accumulation in tumor tissues. In vivo fluorescence imaging using optimized POEGMA derivatives confirmed their suitability as drug carriers for sensitive tumor diagnosis.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Biomedical
Qiang Luo, Ling Lin, Qiaorong Huang, Zhenyu Duan, Lei Gu, Hu Zhang, Zhongwei Gu, Qiyong Gong, Kui Luo
Summary: In this study, an enzyme- and pH-responsive polymeric prodrug was developed by combining a dendronized structure with a poly(oligo-(ethylene glycol) methacrylate) backbone. The prodrug exhibited dual stimuli responsiveness and self-assembled into stable nanoparticles, which showed long-term circulation and enhanced cellular uptake. The nanoparticles demonstrated enhanced therapeutic effect and great hemocompatibility and biosafety. This strategy provides insights for the design of drug delivery carriers based on poly(oligo-(ethylene glycol) methacrylate).
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Rohini Thevi Guntnur, Nicolas Muzzio, Madison Morales, Gabriela Romero
Summary: The phase transition dynamics of POEGMA coatings in response to external temperature stimuli were investigated using QCM-D technology. The reversible phase transition nature of POEGMA brushes was revealed, showing potential as polymer coatings for controlled drug release.
Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Elisa Guazzelli, Luca Santarlasci, Matteo Oliva, Carlo Pretti, Matteo Romio, Antonella Glisenti, Edmondo M. Benetti, Elisa Martinelli
Summary: In this research, similar coatings were formulated using poly(dimethyl siloxane methacrylate)-co-oligo(2-alkyl-2-oxazoline)methacrylate copolymers, and compared with coatings using PEG analogues. The biofouling experiments showed that the copolymers with oligo(2-alkyl-2-oxazoline) grafts exhibited comparable or improved performance compared to PEG-based coatings, highlighting them as a valid alternative for designing antibiofouling coatings.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Mohamed Zoughaib, Kenana Dayob, Svetlana Avdokushina, Marat I. Kamalov, Diana V. Salakhieva, Irina N. Savina, Igor A. Lavrov, Timur I. Abdullin
Summary: Synthetic hydrogels, specifically oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels, have been developed as a potential biodegradable scaffold for spinal cord repair with improved control over properties. The combination of different components in the cryogels allows for optimization of cell-supporting characteristics. The results show that OPF-based cryogels can be a tunable synthetic scaffold for neural tissue repair with advantages over hydrogel counterparts.
Article
Materials Science, Biomaterials
Fei Xu, Chloe Dawson, Todd Hoare
Summary: A reactive cell electrospinning approach is introduced to create nanofibrous hydrogel scaffolds with controllable local cell gradients. This method utilizes hydrazide and aldehyde-functionalized polymers and a sequential all-aqueous process, without the need for additives or external energy. The cells can be encapsulated directly during the fabrication process, allowing for localized segregation of different cell types within the structure while maintaining their proliferative capacity. This approach shows promise in generating coculture fibrous hydrogel networks with controlled nanoscale architecture and cell distribution, essential for recreating complex tissues.
Article
Polymer Science
D. M. Kamorin, A. S. Simagin, D. V. Orekhov, O. A. Kazantsev, E. A. Bolshakova, A. P. Sivokhin, M. V. Savinova, S. V. Orekhov
Summary: The synthesis and solution properties of thermoresponsive polymer molecular brushes based on five novel diblock macromonomers have been studied. The research showed the impact of synthesis conditions on the rate of radical solution polymerization, maximum conversions of macromonomers, and molecular weight characteristics of polymers. Furthermore, it demonstrated the influence of oligo(propylene glycol) block length on surface-active properties and aggregation behavior of the polymers.
Article
Biochemistry & Molecular Biology
Ceren Cokca, Franz J. Hack, Daniel Costabel, Kira Herwig, Juliana Huelsmann, Patrick Then, Rainer Heintzmann, Dagmar Fischer, Kalina Peneva
Summary: This study describes the shielding of a high performing terpolymer using block copolymerization with various molecular weights of P(MEO(9)MA) and investigates its influence on cytotoxicity, pDNA binding, and transfection efficiency. The results show that higher molecular weight P(MEO(9)MA) blocks exhibit excellent biocompatibility and efficient transfection efficiency.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Chemistry, Physical
Maria del Prado Garrido, Ana Maria Borreguero, Francisco Javier Redondo, David Padilla, Manuel Carmona, Maria Jesus Ramos, Juan Francisco Rodriguez
Summary: In this study, St-MMA particles with PEGMA and/or GMA brushes were synthesized and found to effectively remove bilirubin by improving the BSA immobilization capacity and reducing processing time. Attachment of BSA to the particles reduced bilirubin concentration in plasma from levels that threaten patient survival to levels close to those of healthy individuals.
Article
Polymer Science
Maria Simonova, Denis Kamorin, Oleg Kazantsev, Maria Nepomnyashaya, Alexander Filippov
Summary: Polymethacrylic molecular brushes with oligo(ethylene glycol)-block-oligo(propylene glycol) side chains were studied in various solvents, showing molecular dispersion in good solvents like tetrahydrofuran and acetonitrile, and micelle-like aggregate formation in chloroform and water. Critical micelle concentrations decreased with longer hydrophobic blocks, while thermosensitive behavior and lower phase separation temperatures were observed in aqueous solutions with higher oligo(propylene glycol) content.
Article
Polymer Science
Maria Simonova, Alexander Simagin, Denis Kamorin, Sergey Orekhov, Alexander Filippov, Oleg Kazantsev
Summary: The properties of polymer brushes based on three macromonomers were investigated, including their behavior in aqueous and organic solutions, solubility in water and organic solvents, equilibrium distribution between phases, surface activity in water-toluene system, thermo-responsibility in aqueous solutions, and critical concentration of micelle formation.
Article
Engineering, Biomedical
Xifeng Liu, Bipin Gaihre, Matthew N. George, A. Lee Miller, Haocheng Xu, Brian E. Waletzki, Lichun Lu
Summary: This study presents a new bioink made of OPF and gelatin for 3D bioprinting, showing excellent performance in terms of cell viability, spreading, and proliferation. The results indicate that OPF bioink holds great potential in future 3D bioprinting applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)