Article
Biochemistry & Molecular Biology
Kamylla Fernanda Souza de Souza, Danilo Tofoli, Indiara Correia Pereira, Kelly Juliana Filippin, Ana Tereza Gomes Guerrero, Edgar Julian Paredes-Gamero, Maria de Fatima Cepa Matos, Walmir Silva Garcez, Fernanda Rodrigues Garcez, Renata Trentin Perdomo
Summary: The study isolated three compounds from the leaves of Aniba heringeri, with compound 3 showing strong cytotoxicity against breast cancer cells and a high selective index. This compound exhibited promising apoptosis induction effects on triple-negative breast cancer cells, demonstrating potential as a prototype for targeting TNBC cells that are usually resistant to conventional therapies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Tina Rabizadeh, Reyhaneh Varshochian, Athar Mahdieh, Mahsa Rezaei, Negin Pazouki, Mahsa Zardkanlou, Shiva Irani, Rassoul Dinarvand
Summary: In this study, polydopamine-coated superparamagnetic iron oxide nanoparticles were used to deliver the immunomodulatory drug teriflunomide to breast cancer cells. The nanoparticles showed promising potential by increasing cytotoxicity and gene expression in the cells. The study suggests that the designed teriflunomide-loaded nanoparticles could be considered for future breast cancer therapy research.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hadi Chavoshi, Mahsa Taheri, Murphy Lam Yim, Mehdi Sabzichi
Summary: Triple-negative breast cancer (TNBC) is a highly lethal subtype of breast cancer. Crocin-loaded liposomes showed enhanced cytotoxicity when combined with chemotherapy drug doxorubicin (DOX) in MDA-MB-231 cells. The liposome formulation had monodisperse distribution with an average size of 80 nm, about 70% encapsulation efficiency, and 11% loading capacity. The study suggested that crocin-loaded liposomes can be a promising approach against tumor cells, especially when combined with DOX.
PROCESS BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Wadyan Lafi Alsulami, Daoud Ali, Bader O. Almutairi, Khadijah N. Yaseen, Saad Alkahtani, Rafa A. Almeer, Saud Alarifi
Summary: In this study, green lead nanoparticles (gPbNPs) synthesized from Ziziphus spina-christi leaves were found to have cytotoxic and apoptotic effects on human breast cancer cells. The gPbNPs exhibited concentration-dependent toxicity and increased intracellular ROS generation. The upregulation of the Bax gene and downregulation of the Bcl-2 gene, along with increased caspase 3/7 activity, confirmed the apoptotic effect of gPbNPs. Overall, gPbNPs activated caspase 3/7 activity and exerted toxic effects on the breast cancer cells.
Article
Biochemistry & Molecular Biology
Qinhang Wu, Xuejiao Leng, Xuelin Ma, Qixuan Xu, Ruijun Ni, Yang Pan, Zhuolin Jin, Muhammad Kalim
Summary: Triptolide has a metastatic inhibitory effect on MDA-MB-231 cells by targeting ROCK1 and inhibiting the epithelial-mesenchymal transition. It suppresses cell proliferation, induces cell apoptosis, and reduces migration and invasion capabilities of the cells. Triptolide also affects the expressions of various proteins associated with metastasis.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Leide Laura Figueiredo Maciel, Marina Barreto Silva, Rafaela Oliveira Moreira, Ana Paula Cardoso, Christiane Fernandes, Adolfo Horn Jr, Joao Carlos de Aquino Almeida, Milton Masahiko Kanashiro
Summary: This study investigated the antineoplastic activity of two platinum complexes containing alpha- and beta-naphthyl groups. The results showed that one of the platinum complexes exhibited higher cytotoxicity against all cancer cell lines tested and lower cytotoxicity against normal peripheral blood mononuclear cells. Further investigations revealed that this complex induced cell death by apoptosis and was associated with mitochondrial membrane depolarization, elevated levels of reactive oxygen species (ROS), and caspase activation.
Article
Microbiology
Ji-In Noh, Seul-Ki Mun, Eui Hyeon Lim, Hangun Kim, Dong-Jo Chang, Jae-Seoun Hur, Sung-Tae Yee
Summary: Physconia hokkaidensis methanol extract (PHE) exhibited selective cytotoxicity towards MDA-MB-231 triple-negative breast cancer cells, inducing apoptosis as its mechanism of action.
Article
Nutrition & Dietetics
Dahae Lee, Seulah Lee, Yoon Seo Jang, Rhim Ryoo, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim
Summary: This study investigated the cytotoxicity of the mushroom Calvatia nipponica in human breast cancer cells and identified potential anti-tumor compounds. The results suggest that N,N-dimethyl-anthranilic acid may have anti-breast cancer activity and induce apoptosis through extrinsic and intrinsic signaling pathways.
Article
Chemistry, Inorganic & Nuclear
Maria Dalla Pozza, Pierre Mesdom, Ahmad Abdullrahman, Tayler D. Prieto Otoya, Philippe Arnoux, Celine Frochot, Germain Niogret, Bruno Saubamea, Pierre Burckel, James P. Hall, Marcel Hollenstein, Christine J. Cardin, Gilles Gasser
Summary: Lack of selectivity is a main issue with current chemotherapies, and photodynamic therapy (PDT) using ruthenium(II) polypyridyl compounds as photosensitizers shows promise in treating diseases like cancer and bacterial infections. The synthesized Ru(II) compounds demonstrated high singlet oxygen quantum yields and significant photocytotoxic properties against cancer cells. The study also revealed the mitochondrial localization of certain compounds and the disruption of mitochondrial respiration after light irradiation.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Aykut Ozgur, Altan Kara, Nazan Goksen Tosun, Saban Tekin, Isa Gokce
Summary: Heat shock protein 90 (Hsp90) is a key chaperone overexpressed in cancer cells, making it a potential target for cancer therapy. Debio-0932, a second-generation inhibitor, showed promising anticancer activity by binding strongly to Hsp90 and inducing apoptosis in breast cancer cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Zhu, Hui Liu, Yang Dou, Qun Luo, Liangzhen Gu, Xingkai Liu, Qianxiong Zhou, Juanjuan Han, Fuyi Wang
Summary: In this study, the photoactivated ruthenium polypyridine complex ZQX-1 showed selective cytotoxicity to hypoxic and cisplatin-resistant cancer cells, inducing apoptosis and necrosis. It also inhibited DNA repair-related proteins and enhanced the photocytotoxicity of the prodrug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli Wei
Summary: In the study, it was found that wikstromol inhibited cell growth and induced apoptosis in TNBC cells, suppressed cell migration, and the inhibitory effects were involved in the inactivation of the PI3K/Akt pathway.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.
Article
Biophysics
Rahman Hallaj, Zhaleh Ghafary, Osama kamal Mohammed, Raheleh Shakeri
Summary: The study developed an electrochemical biosensor for detecting the endogenous protein of breast cancer cells using RNA-cleaving DNAzymes. Thionine-modified gold nanoparticles and modified magnetic nanoparticles were used to prepare a probe, which was then pulled to the electrode surface with the help of a magnetic field. The presence of gold nanoparticle-thionine hybrid as an electroactive label ensured strong detection signals. The biosensor showed a linear range of (1.0E-06 to 1.0E+01) pg/ml for the protein marker and a detection limit of (1.0129E-07 pg/ml) using differential pulse voltammetry and electrochemical impedance spectroscopy (EIS).
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Medicine, Research & Experimental
Hamid E. Daaboul, Carole Dagher, Robin I. Taleb, Kikki Bodman-Smith, Wassim N. Shebaby, Mirvat El-Sibai, Mohamad A. Mroueh, Costantine F. Daher
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Chemistry, Inorganic & Nuclear
Najwa Mansour, Stephanie Mehanna, Mohamad A. Mroueh, Hassib Audi, Kikki Bodman-Smith, Costantine F. Daher, Robin I. Taleb, Mirvat El-Sibai, Rony S. Khnayzer
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Physical
Hassib Audi, Daniel F. Azar, Farah Mahjoub, Stephanie Farhat, Zeinab El Masri, Mirvat El-Sibai, Ralph J. Abi-Habib, Rony S. Khnayzer
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Nabil El Zein, Maya S. Abdallah, Costantine F. Daher, Mohammad Mroueh, Joseph Stephan, Sola Aoun Bahous, Assaad Eid, Wissam H. Faour
CELL BIOCHEMISTRY AND FUNCTION
(2019)
Article
Chemistry, Multidisciplinary
Mahmoud Elcheikh Mahmoud, Hassib Audi, Abdeljalil Assoud, Tarek H. Ghaddar, Mohamad Hmadeh
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Hamid E. Daaboul, Carole Dagher, Robin Taleb, Kikki Bodman-Smith, Wassim N. Shebaby, Mirvat El-Sibai, Mohamad A. Mroueh, Costantine F. Daher
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Multidisciplinary Sciences
Andree Elias, Wassim N. Shebaby, Bilal Nehme, Wissam Faour, Bassem S. Bassil, Joelle El Hakim, Rita Iskandar, Nahia Dib-Jalbout, Mohamad Mroueh, Costantine Daher, Robin Taleb
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Maria George Elias, Stephanie Mehanna, Elias Elias, Rony S. Khnayzer, Costantine F. Daher
Summary: The study demonstrates that the photoactivated chemotherapy drug [Ru(bpy)2BC]Cl2 has multi-mechanistic effects, increasing cytotoxicity by inducing ROS production and DNA damage. It mediates apoptosis by interfering with pathways related to cell apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
H. Audi, Y. Viero, N. Alwhaibi, Z. Chen, M. Iazykov, A. Heynderickx, F. Xiao, D. Guerin, C. Krzeminski, I. M. Grace, C. J. Lambert, O. Siri, D. Vuillaume, S. Lenfant, H. Klein
Article
Chemistry, Multidisciplinary
Stephanie Mehanna, Najwa Mansour, Hassib Audi, Kikki Bodman-Smith, Mohamad A. Mroueh, Robin I. Taleb, Costantine F. Daher, Rony S. Khnayzer
Meeting Abstract
Chemistry, Multidisciplinary
Najwa Mansour, Stephanie Mehanna, Mirvat El Sibai, Rony Khnayzer, Costantine Daher
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Meeting Abstract
Chemistry, Multidisciplinary
Robin Taleb, Costantine Daher, Mirvat El Sibai, Mohamad Mroueh
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)