Article
Chemistry, Physical
Michael J. Lucas, Henry S. Pan, Eric J. Verbeke, Gina Partipilo, Ethan C. Helfman, Leah Kann, Benjamin K. Keitz, David W. Taylor, Lauren J. Webb
Summary: This study explores the influence of mutant seeds on the distribution of fibril structural polymorphs in wild-type (WT) A beta(1-40) and investigates the impact of structural distribution changes on toxicity. The findings indicate that mutant fibril seeds not only impart their structure to growing WT A beta(1-40) aggregates but also impart cytotoxic properties.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Biology
Yijing Tang, Dong Zhang, Yanxian Zhang, Yonglan Liu, Yifat Miller, Keven Gong, Jie Zheng
Summary: This study reveals a potential crosstalk between Alzheimer's Disease (AD) and HIV/AIDS through the cross-seeding interactions between Aβ and SEVI proteins. The cross-seeding of SEVI with Aβ can prevent Aβ aggregation, reduce Aβ-induced cell toxicity, and attenuate Aβ-accumulated paralysis in transgenic AD C. elegans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kailash Prasad Prajapati, Bibin Gnanadhason Anand, Masihuzzaman Ansari, Ashu Bhan Tiku, Karunakar Kar
Summary: Dietary consumption of Trp is essential for crucial metabolic processes. Abnormal build-up of Trp causes brain-related medical complications. Under physiologically mimicked conditions, Trp self-assembles into amyloid-mimicking nanofibers. These Trp nanofibers have high affinity for native proteins and can induce amyloid formation. They also show toxic effects on neuroblastoma cells. This study provides insights into Trp-related complications and has significance for nanomaterials design.
Review
Engineering, Chemical
Yanxian Zhang, Yijing Tang, Dong Zhang, Yonglan Liu, Jian He, Yung Chang, Jie Zheng
Summary: The research focuses on the mechanism of amyloid cross-seeding between Aβ and hIAPP and its connection between AD and T2D, explores the role of structural compatibility and sequence similarity of amyloid proteins in cross-seeding, and proposes current challenges and future research directions in this less-studied field.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Review
Cell Biology
Chenglong Yang, Xiaoyuan Zhang, Xiaowen Yang, Fuming Lian, Zongrun Sun, Yongming Huang, Wenzhi Shen
Summary: G protein signalling regulator (RGS) family plays a crucial role in regulating tumor progression and has potential applications in tumor diagnosis, treatment, and prognosis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Plant Sciences
Ruimin Tang, Haitao Dong, Liheng He, Peng Li, Yuanrui Shi, Qing Yang, Xiaoyun Jia, Xiu-Qing Li
Summary: This study investigated the structure, evolution, and expression characteristics of the KFB family in potato. A total of 44 members of the StKFB gene family were identified and classified into 5 groups. Chromosomal localization analysis revealed that these genes are located on 12 chromosomes of potato. Expression profiling in different tissues and under different treatments demonstrated distinct spatial expression patterns and potential roles in stress responses. Furthermore, differential expression of StKFB genes in different colored potato tubers suggested their involvement in anthocyanin biosynthesis.
Article
Chemistry, Multidisciplinary
Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng
Summary: This study demonstrates a rational design strategy of an amyloid-aggregation-induced emission (AIE)-active molecule, G7-TBA, which serves as a multiple-target, dual-function amyloid probe and modulator for detecting, monitoring, and altering amyloid aggregation of different amyloid proteins.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Abbas Salimi, Sompriya Chatterjee, Jin Yong Lee
Summary: Clinical research suggests that Type 2 diabetes (T2D) may be a risk factor for Alzheimer's disease (AD) development, possibly due to the improper aggregation of Amyloid-beta (Aβ) in both diseases. This computational research reveals the cross-seeding between Amylin1-37 and Aβ 40, shedding light on the pathological link between AD and T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haley V. Parker, Christine E. Schaner Tooley
Summary: N-terminal protein methylation is a post-translational modification that regulates protein stability, protein-DNA interactions, and protein-protein interactions. The regulatory mechanisms of the modifying methyltransferases are not completely understood.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Chloe French, Simon Lal, Debra Jones, Anne Marie Sowerbutts, Diane Brundrett, Nicola Burch, Chris Calvert, Sheldon C. Cooper, Clare Donnellan, Alastair Forbes, Simon Gabe, Ching Lam, Giles Major, Christopher G. Mountford, Rebecca Muggridge, Brenavan Natarajan, Penny Neild, Dan Rogers, Lisa Sharkey, Beth Thompson, Carolyn Wheatley, Sorrel Burden
Summary: This study aimed to assess the burden on family members involved in the care of patients receiving home parenteral nutrition (HPN) and to identify specific factors contributing to this burden. The results showed that HPN has a moderate impact on patients' quality of life, and 23% of family members reported a moderate to very severe subjective burden, indicating an increased risk of psychosomatic symptoms. Predictors of burden on family members included their self-reported health status and support received from health services, while employment status, disease type, number of nights on HPN, and length of time on HPN were not associated with burden.
CLINICAL NUTRITION
(2022)
Review
Materials Science, Multidisciplinary
Sehrish Manan, Muhammad Wajid Ullah, Mazhar Ul-Islam, Zhijun Shi, Mario Gauthier, Guang Yang
Summary: Bacterial cellulose (BC) or bacterial nanocellulose (BNC) is gaining attention for its purity and superior features. However, low yield and productivity, as well as high cost, hinder the industrial-scale production and commercial applications. Molecular studies have revealed specific operons involved in BC biosynthesis and transport, and genetic engineering has been used to enhance BC yield and improve its structural features. This review aims to improve BC production and develop strategies for the development of BC-based hybrid materials with improved features.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Atsushi Kaida, Tomoo Iwakuma
Summary: Heat shock proteins (HSPs) are molecular chaperones that assist various cellular activities, including protein folding, intracellular transportation, and stabilization or degradation of misfolded proteins. HSP40, the largest family in HSPs, interacts functionally with tumor suppressor protein p53 and plays a role in regulation of its activities in cancer signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Tommaso Sconocchia, Giuseppe Sconocchia
Summary: Bone morphogenetic proteins (BMPs) are potent signaling molecules that play a crucial role in regulating the differentiation, activation, and function of the main cell types of the immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Catalin Vasile Maftei, Martin Heiko Franz, Christian Kleeberg, Ion Neda
Summary: This study presents a short and direct pathway for the synthesis of new compounds of Cinchona alkaloids using Huisgen cycloaddition, converting amines into azides and successfully synthesizing triazole derivatives. Additionally, derivatives of quincorine and quincoridine were used as addition partners to carry the characteristic structure of Cinchona alkaloids in the newly synthesized compounds.
Article
Nursing
Mahdi Shamali, Hanne Konradsen, Erla K. Svavarsdottir, Mohsen Shahriari, Audur Ketilsdottir, Birte ostergaard
Summary: This international study examined family functioning, family health, and social support in patients with heart failure and their family members. The findings suggest that family health is the strongest factor associated with higher family functioning, while women, patients in NYHA class I, and family members with lower educational levels may have lower levels of family functioning.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Chemistry, Physical
Benjamin J. Wylie, Hoa Q. Do, Collin G. Borcik, Emily P. Hardy
Article
Multidisciplinary Sciences
Faraz M. Harsini, Sukanya Chebrolu, Kerry L. Fuson, Mark A. White, Anne M. Rice, R. Bryan Sutton
SCIENTIFIC REPORTS
(2018)
Review
Andrology
G. A. Cornwall, H. Q. Do, A. Hewetson, A. Muthusubramanian, C. Myers
Article
Multidisciplinary Sciences
Hoa Quynh Do, Aveline Hewetson, Caitlyn Myers, Nazmul H. Khan, Mary Catherine Hastert, Faraz M. Harsini, Michael P. Latham, Benjamin J. Wylie, R. Bryan Sutton, Gail A. Cornwall
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Reza Amani, Collin G. Borcik, Nazmul H. Khan, Derek B. Versteeg, Maryam Yekefallah, Hoa Q. Do, Heather R. Coats, Benjamin J. Wylie
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Aveline Hewetson, Nazmul H. Khan, Matthew J. Dominguez, Hoa Quynh Do, R. E. Kusko, Collin G. Borcik, Daniel J. Rigden, Ronan M. Keegan, R. Bryan Sutton, Michael P. Latham, Benjamin J. Wylie, Gail A. Cornwall
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Murugesh Padmanarayana, Haowen Liu, Francesco Michelassi, Lei Li, Daniel Betensky, Matthew J. Dominguez, R. Bryan Sutton, Zhitao Hu, Jeremy S. Dittman
Summary: The HC2M module is a crucial part of Munc13-1, necessary for synaptic vesicle priming during neurotransmitter release, and can be functionally replaced by protein domains that localize to synaptic vesicles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hoa Quynh Do, Carla M. Bassil, Elizabeth Andersen, Michaela Jansen
Summary: The study investigated the impact of different lipids within Lipid-protein nanodiscs (LPNs) on soluble PCFT expression, revealing insights into the lipid preferences of PCFT and providing crucial information for further research on folate transport.
Article
Multidisciplinary Sciences
Matthew J. Dominguez, Jon J. Mccord, R. Bryan Sutton
Summary: Ferlins are complex proteins involved in membrane processes. In this study, we used computational methods to explore the structure and domain boundaries of ferlin proteins. We identified a previously unknown C2 domain in all human ferlins. This research provides valuable insights into the structure of ferlin proteins.
Article
Biology
Jon J. McCord, Minal Engavale, Elahe Masoumzadeh, Johanna Villarreal, Britney Mapp, Michael P. Latham, Peter A. Keyel, R. Bryan Sutton
Summary: Autoimmunity arises when extracellular DNA released from dying cells is not cleared, and Dnase1L3 plays a unique role in degrading antigenic forms of cell-free DNA. The interaction between the core catalytic domain and the C-terminal domain of Dnase1L3 is essential for its distinct DNA degradation mechanism. These findings have implications for the development of Dnase1L3-based therapies for autoimmunity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Physiology
Hoa Quynh Do, Michaela Jansen
Summary: This study identifies the binding motif for RIC-3 protein in the 5-HT3A subunits of serotonin channels and confirms its importance in modulating functional surface expression. The discovery positions this interaction as a potential drug target for treating 5-HT3A-related disorders and opens up new research directions for understanding channel biogenesis.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aveline Hewetson, Hoa Quynh Do, Caitlyn Myers, Archana Muthusubramanian, Roger Bryan Sutton, Benjamin J. Wylie, Gail A. Cornwall