Review
Chemistry, Medicinal
Nalini Sodum, Gautam Kumar, Vanishree Rao, Nitesh Kumar, Chamallamudi Mallikarjuna Rao
Summary: This review provides detailed information on the origin, transmission, clinical features, treatment methods, and vaccine trials of the COVID-19 outbreak. Currently, early detection, isolation of infected individuals, and intensive care medicine are crucial in combating the pandemic.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Editorial Material
Microbiology
Andrea Du Toit
Summary: This study examines the effectiveness of exogenous pegylated IFN lambda in treating patients with COVID-19.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Critical Care Medicine
Pedro D. Wendel Garcia, Hernan Aguirre-Bermeo, Philipp K. Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger, Maddalena A. Wu, Riccardo Colombo, Fabrizio Turrini, Antonella Potalivo, Emanuele Rezoagli, Raquel Rodriguez-Garcia, Pedro Castro, Arantxa Lander-Azcona, Maria C. Martin-Delgado, Herminia Lozano-Gomez, Rolf Ensner, Marc P. Michot, Nadine Gehring, Peter Schott, Martin Siegemund, Lukas Merki, Jan Wiegand, Marie M. Jeitziner, Marcus Laube, Petra Salomon, Frank Hillgaertner, Alexander Dullenkopf, Hatem Ksouri, Sara Cereghetti, Serge Grazioli, Christian Burkle, Julien Marrel, Isabelle Fleisch, Marie-Helene Perez, Anja Baltussen Weber, Samuele Ceruti, Katharina Marquardt, Tobias Hubner, Hermann Redecker, Michael Studhalter, Michael Stephan, Daniela Selz, Urs Pietsch, Anette Ristic, Antje Heise, Friederike Meyer zu Bentrup, Marilene Franchitti Laurent, Patricia Fodor, Tomislav Gaspert, Christoph Haberthuer, Elif Colak, Dorothea M. Heuberger, Thierry Fumeaux, Jonathan Montomoli, Philippe Guerci, Reto A. Schuepbach, Matthias P. Hilty, Ferran Roche-Campo
Summary: The study found that high-flow oxygen therapy (HFNC) as the initial respiratory support strategy for critically ill COVID-19 patients appeared to be the most balanced, reducing intubation rates and having comparable ICU mortality rates to standard oxygen therapy (SOT). However, noninvasive positive-pressure ventilation (NIV) as a respiratory support strategy was associated with an elevated ICU mortality risk, and should be avoided whenever possible.
Letter
Infectious Diseases
D'Abramo Alessandra, Vita Serena, Nicastri Emanuele
Summary: This study examines the use of SARS-CoV-2 antivirals and/or monoclonal antibodies in immunocompromised patients, supporting the use of early combination therapy and advocating for a tailored and standardized therapeutic approach in this population.
BMC INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
David Fisher, Stephen Malnick
Summary: The researchers administered convalescent plasma to high-risk outpatients within 1 week after the onset of symptoms of Covid-19, which differs from previous studies with shorter time frames.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Peter W. Marks, Philip A. Gruppuso, Eli Y. Adashi
Summary: This Viewpoint emphasizes the importance of developing a significantly improved generation of SARS-CoV-2 vaccines in order to provide greater and longer-lasting protection against COVID-19 disease.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Microbiology
Michela Pontolillo, Claudio Ucciferri, Paola Borrelli, Marta Di Nicola, Jacopo Vecchiet, Katia Falasca
Summary: This study reports the experience of using molnupiravir in the treatment of COVID-19 patients. The results show that participants demonstrated early clinical improvement, no need for hospitalization, and a low rate of adverse events after receiving the treatment.
Letter
Medicine, General & Internal
Stefan Hatzl, Robert Krause, Gernot Schilcher
Summary: The trial conducted by Gupta et al. has three major drawbacks, including an arbitrary definition of high risk and inadequate study on patients with compromised immune function.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
F. Moretto, T. Sixt, H. Devilliers, M. Abdallahoui, I Eberl, T. Rogier, M. Buisson, P. Chavanet, M. Duong, C. Esteve, S. Mahy, A. Salmon-Rousseau, F. Catherine, M. Blot, L. Piroth
Summary: An analysis of COVID-19 patients hospitalized in the Infectious Diseases Department of Dijon University Hospital in France found that although 78% of patients received antibiotic therapy, those who received antibiotics had more severe presentation at admission. However, antibiotic therapy was not significantly associated with patient outcomes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Francesco Cavallieri, Valentina Fioravanti, Francesco Bove, Eleonora Del Prete, Sara Meoni, Sara Grisanti, Marialuisa Zedde, Rosario Pascarella, Elena Moro, Franco Valzania
Summary: This review summarizes the clinical, biological, and neuroimaging features of COVID-19-related parkinsonism and discusses the possible pathophysiological mechanisms. The appearance of parkinsonism during or immediately after COVID-19 infection is a very rare event. Different mechanisms, including vascular damage and neuroinflammation, may play a role, and further long-term observational studies are needed to evaluate the association between COVID-19 infection and the development of Parkinson's Disease.
Article
Education & Educational Research
Wenwen Tian, Stephen Louw, Muhammad Kamal Khan
Summary: Three participant-researchers in China, Thailand, and Pakistan explored their language assessment literacy during school shutdowns caused by the Covid-19 pandemic. Their initial reflections showed lack of confidence in LAL and perception of assessment as theoretical, but as the study progressed, they became more confident and touched on sensitive topics, highlighting the importance of remote reflections for professional development across cultures.
Review
Immunology
Helen C. Su, Huie Jing, Yu Zhang, Jean-Laurent Casanova
Summary: Infection with SARS-CoV-2 can result in a wide range of clinical outcomes, from no symptoms to severe pneumonia and death. Genetic studies have shown that severe cases may be caused by defects in the type I interferon immune response or presence of autoantibodies that neutralize interferons. Virological and cellular studies have further demonstrated that SARS-CoV-2 proteins can hinder the induction or response to type I interferons, while these interferons can limit viral replication. These findings highlight the importance of sufficient type I interferon during the early stages of infection and have implications for treatment and future research.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Chang Suk Noh, Won-Young Kim, Moon Seong Baek
Summary: Factors associated with the need for oxygen therapy in patients with COVID-19 included being a current smoker, elevated heart rate, aspartate aminotransferase values, blood urea nitrogen levels, and chest radiographic findings. Further research on risk factors for deterioration in COVID-19 is warranted to efficiently allocate medical resources.
Review
Gastroenterology & Hepatology
Ming-Ke Wang, Xue-Lu Yu, Li-Yun Zhou, Hong-Mei Si, Ju-Fen Hui, Deng-Yong Hou, Wei-Peng Li, Ji-Shun Yang
Summary: COVID-19 patients often have liver dysfunction, and the degree of liver dysfunction is associated with disease severity and prognosis. Nutritional therapy measures, including natural dietary supplements, vitamins, minerals, trace elements, and probiotics, may have potential hepatoprotective effects.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Chemistry, Multidisciplinary
Eugene N. Muratov, Rommie Amaro, Carolina H. Andrade, Nathan Brown, Sean Ekins, Denis Fourches, Olexandr Isayev, Dima Kozakov, Jose L. Medina-Franco, Kenneth M. Merz, Tudor Oprea, Vladimir Poroikov, Gisbert Schneider, Matthew H. Todd, Alexandre Varnek, David A. Winkler, Alexey Zakharov, Artem Cherkasov, Alexander Tropsha
Summary: COVID-19 has led to a large number of infections and deaths globally, causing severe disruptions to societies and economies. Extensive experimental and computational research efforts have been made to quickly develop diagnostics, vaccines, and drugs to combat the pandemic. Although drug repurposing has not provided rapid and global solutions, known drugs have been used in clinical settings and new clinical candidates are being considered in trials. Truly impactful computational tools that provide testable hypotheses and rapid sharing of research results are crucial for the development of much-needed therapeutics for COVID-19.
CHEMICAL SOCIETY REVIEWS
(2021)
