Article
Multidisciplinary Sciences
Guiping Jiang, Xueping Wu
Summary: This study investigated the age-related differences in walking speed and global cognitive function among older adults in China and found an association between walking speed and cognitive function.
Article
Engineering, Biomedical
A. Soltani, K. Aminian, C. Mazza, A. Cereatti, L. Palmerini, T. Bonci, A. Paraschiv-Ionescu
Summary: This study implemented and compared various algorithms to estimate walking speed based on data from people with different preferred walking speeds. Training algorithms on diverse speed datasets led to performance improvements, and errors varied for different walking speeds with significantly increased error for people using walking aids.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Chemistry, Analytical
David Moulaee Conradsson, Lucian John-Ross Bezuidenhout
Summary: This study aimed to develop cut-points for waist- and ankle-worn accelerometers to differentiate non-ambulation from walking and different walking speeds in people post stroke. The researchers used validation studies to interpret the data and found good-to-excellent classification accuracy for cut-points across all speed categories. These findings are important for investigating the link between walking and health outcomes in people post stroke.
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jinuk Kim, Jungsoo Lee, Gihyoun Lee, Won Hyuk Chang, Myoung-Hwan Ko, Woo-Kyoung Yoo, Gyu-Ha Ryu, Yun-Hee Kim
Summary: This study investigated the correlation between lower limb muscle activity and cortical activation during treadmill walking in two groups of elderly people: the young-old and the old-old. The results showed that there was a strong correlation between lower extremity muscle activity and cortical activation, especially in the swing phase, and this correlation was significantly stronger in the young-old compared to the old-old. The study also found that the correlations between muscle activity and cortical activation were stronger during fast walking and cognitive dual-task walking than during comfortable walking in both groups.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Evelyne Liuu, Pierre-Jean Saulnier, Elise Gand, Gautier Defossez, Amelie Jamet, Stephanie Ragot, Marc Paccalin, Samy Hadjadj
Summary: This study investigated whether diabetic micro- and macrovascular complications (mMVC) influence cancer-related events in people with type 2 diabetes. The findings showed that mMVC were not associated with cancer-related events, but a personal history of cancer was significantly associated with cardiovascular death.
DIABETES & METABOLISM
(2022)
Article
Computer Science, Information Systems
Wan Shi Low, Kheng Yee Goh, Sim Kuan Goh, Chen Hua Yeow, Khin Wee Lai, Siew Li Goh, Joon Huang Chuah, Chow Khuen Chan
Summary: Walking speed is a good indicator for recognizing gait abnormalities, and this study proposes the use of a deep learning framework with recurrent neural network (RNN) to interpret human walking speed, aiming to improve the accuracy of clinical diagnoses.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Jorge Berlanga-Acosta, Ariana Garcia-Ojalvo, Gerardo Guillen-Nieto, Marta Ayala-Avila
Summary: An impaired healing response in diabetic foot wounds leads to chronicity, amputation, disability, and mortality. Recurrence of post-epithelization ulcers in diabetics is high and may be caused by both behavioral and endogenous biological factors. Chronic hyperglycemia and its biological effects play a significant role in ulcer recurrence by inducing abnormal pathologic phenotypes to memory cells. The infiltration of epidermal growth factor shows promising remission data with low recurrence rates during follow-up.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
Lucas R. Nascimento, Augusto Boening, Abilio Galli, Janaine C. Polese, Louise Ada
Summary: This systematic review suggests that treadmill walking has the same or better effect on walking speed and distance in ambulatory people after stroke compared to overground walking, but the long-term effects and carryover benefits to participation remain uncertain.
JOURNAL OF PHYSIOTHERAPY
(2021)
Article
Chemistry, Analytical
Marco Iosa, Maria Grazia Benedetti, Gabriella Antonucci, Stefano Paolucci, Giovanni Morone
Summary: Many recent studies have shown that the harmony of physiological walking depends on the proportions between the phases of the gait cycle. The gait cycle assumes a fractal structure when the proportion is close to the golden ratio. In stroke patients, this harmony is disrupted, and it is unclear which factor is associated with the ratios between gait phases. Using an artificial neural network, researchers found that the gait ratio is associated with walking speed, stride length, and hip muscle forces.
Review
Endocrinology & Metabolism
Ziyan Xie, Xinhua Xiao
Summary: This paper reviews the recent advancements in novel biomarkers, artificial intelligence technology, therapeutic agents, and approaches for diabetic retinopathy and nephropathy, providing valuable insights into the management of microvascular complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Benedetta Maria Bonora, Mattia Albiero, Mario Luca Morieri, Roberta Cappellari, Francesco Ivan Amendolagine, Marta Mazzucato, Alberto Zambon, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini
Summary: This study aimed to investigate the effect of fenofibrate on circulating haematopoietic stem/progenitor cells (HSPCs) in patients with diabetic retinopathy. The results showed that fenofibrate significantly increased the levels of HSPCs expressing CD34 and/or CD133, potentially explaining its role in reducing retinopathy progression.
Article
Psychology, Social
Jan te Nijenhuis, Edward Dutton, Kyu Yeong Choi, Yu Yong Choi, Jang Jae Lee, Eun Hyun Seo, Hoowon Kim, Kun Ho Lee
Summary: The study examines the relationship between religion and IQ among elderly South Koreans, finding that elderly nonreligious individuals have lower IQ scores compared to religious individuals, contrary to findings in Western societies. The discrepancy is attributed to differences in how the concept of religion is understood in different cultural contexts.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Chemistry, Multidisciplinary
Yi Liu, Honglei An, Hongxu Ma, Qing Wei
Summary: This paper proposes a novel online walking speed estimation method using an inertial measurement unit (IMU) on the thigh. The proposed method is evaluated on a public open-source dataset and the experiment results show that it offers higher accuracy and good performances in static speeds and dynamic speed tracking.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Susan W. Hunter, Aysha Motala, Alicia E. Cronin, Robert Bartha, Ricardo Viana, Michael W. Payne
Summary: Every year, a significant number of adults in Canada undergo limb amputation, with lower limb amputation being the most common. Enhancing walking ability is crucial for rehabilitation and community reintegration. However, there is limited evidence on brain activation during motor imagery in individuals with lower limb amputation. This study used functional magnetic resonance imaging (fMRI) to observe brain activation during imagined walking in individuals with lower limb amputation and found greater activation in frontal regions and the primary motor cortex.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Mathias D. G. Van den Eynde, Alfons J. H. M. Houben, Jean L. J. M. Scheijen, Armand M. A. Linkens, Petra M. Niessen, Nynke Simons, Nordin M. J. Hanssen, Yvo H. A. M. Kusters, Simone J. M. P. Eussen, Toshio Miyata, Coen D. A. Stehouwer, Casper G. Schalkwijk
Summary: This study found that pyridoxamine (PM), a B6 vitamer and dicarbonyl scavenger, can reduce methylglyoxal (MGO), protein-bound N delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). However, PM does not affect insulin sensitivity and vascular function.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Francis Q. S. Dzakpasu, Annemarie Koster, Neville Owen, Bastiaan E. de Galan, Alison Carver, Christian J. Brakenridge, Annelies Boonen, Hans Bosma, Pieter C. Dagnelie, Simone J. P. M. Eussen, Parneet Sethi, Coen D. A. Stehouwer, Nicolaas C. Schaper, David W. Dunstan
Summary: This study found a significant association between daily sitting time and knee pain in middle-aged and older adults with type 2 diabetes. However, no significant association was observed between sitting time and neck, shoulder, or low back pain in any of the models. Further studies are needed to examine the relationship between sitting time and different types of pain, as well as other aspects of sedentary behavior.
Article
Endocrinology & Metabolism
Veerle van Hulten, Johanna H. M. Driessen, Jakob K. Starup-Linde, Zheer K. Al-Mashhadi, Rikke Viggers, Olaf H. Klungel, Patrick C. Souverein, Peter Vestergaard, Coen D. A. Stehouwer, Joop P. van den Bergh
Summary: A study compared the use of SGLT2 inhibitors and DPP-4 inhibitors as add-on to metformin and found no significant difference in the risk of fractures or major osteoporotic fractures between the two groups.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: Early diagnosis and ongoing monitoring and treatment of peripheral artery disease (PAD) is crucial for reducing the risk of foot ulcer development, non-healing of wounds, infection, amputation, and cardiovascular complications in patients with diabetes. Various non-invasive bedside tests are available for diagnosing PAD, but the most accurate test and its reliability for ongoing monitoring are still uncertain. This systematic review aimed to determine the diagnostic accuracy of non-invasive bedside tests for identifying PAD and their reliability in adults with diabetes. The review included 40 studies on diagnostic accuracy and 7 studies on reliability. Ankle-brachial index (ABI) was the most investigated test. The review found that an ABI <0.9 increases the likelihood of disease, while an ABI within the normal range (≥0.90 and <1.3) does not exclude PAD. Toe-brachial index (TBI) and Doppler waveforms in the pedal arteries were also associated with PAD presence. Several bedside tests showed acceptable reliability, but the margin of error was wide. No single or combination of bedside tests demonstrated superior diagnostic accuracy for PAD in patients with diabetes. However, an ABI of 1.3, TBI <0.70, and absent or monophasic pedal Doppler waveforms can help identify the presence of disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Robert Hinchliffe, Joseph Mills, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Russell David, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: This systematic review aimed to determine the performance of non-invasive bedside tests for predicting the outcomes of DFU healing, minor amputation, and major amputation in people with diabetes and DFU or gangrene. The results showed that a toe pressure of ≥30 mmHg, TcPO2 of ≥25 mmHg, and skin perfusion pressure of ≥40 mmHg were associated with a moderate to large increase in the likelihood of DFU healing. However, there is limited research on the prognostic capacity of bedside testing for healing post-minor amputation or major amputation in people with DFU. Current evidence suggests that an ABI <0.4 may be associated with a large increase in the risk of major amputation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Endocrinology & Metabolism
Rianneke de Ritter, Coen D. A. Stehouwer
Article
Endocrinology & Metabolism
Sara B. A. Mokhtar, Frank C. T. van der Heide, Karel A. M. Oyaert, Carla J. H. van der Kallen, Tos T. J. M. Berendschot, Fabio Scarpa, Alessia Colonna, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Pieter C. Dagnelie, Casper G. Schalkwijk, Rudy M. M. A. Nuijts, Nicolaas C. Schaper, Abraham A. Kroon, Miranda T. Schram, Carroll A. B. Webers, Coen D. A. Stehouwer
Summary: This study used population-based observational cross-sectional data to assess the associations between glucose metabolism status and measures of glycaemia with corneal nerve fibre measures. The results showed a linear association between adverse glucose metabolism status, higher levels of glycaemic measures, and corneal neurodegeneration. This study provides evidence that hyperglycaemia-associated corneal neurodegeneration is a continuous process that occurs before the onset of type 2 diabetes.
Article
Multidisciplinary Sciences
Balazs Erdos, Bart van Sloun, Gijs H. Goossens, Shauna D. O'Donovan, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Coen D. A. Stehouwer, Miranda T. Schram, Ellen E. Blaak, Michiel E. Adriaens, Natal A. W. van Riel, Ilja C. W. Arts
Summary: The combination of mechanistic and data-driven modeling approaches is explored in studying individual glucose regulation, and personalized mechanistic models are found to outperform data-driven models in predicting glucose and insulin responses.
Article
Clinical Neurology
Jeroen D. Albers, Ree M. Meertens, Hans H. C. M. Savelberg, Sebastian Kohler, Anke Wesselius, Miranda T. Schram, Coen D. A. Stehouwer, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Simone J. P. M. Eussen, Hans Bosma, Nicolaas C. Schaper, Annemarie Koster
Summary: There is a U-shaped association between sleep duration and type 2 diabetes, where both short and long sleep durations are independently and positively correlated with type 2 diabetes, but not with prediabetes.
Article
Gastroenterology & Hepatology
Zhewen Ren, Hans Bosma, Anke Wesselius, Simone J. P. M. Eussen, M. Eline Kooi, Carla J. H. van der Kallen, Annemarie Koster, Marleen M. J. van Greevenbroek, Pieter Dagnelie, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers
Summary: Individuals with lower socioeconomic position have higher intrahepatic lipid content compared to those with higher socioeconomic position, which may be attributed to unhealthy lifestyle factors such as reduced physical activity and higher intake of sugar sweetened beverages. However, other yet unknown factors may also play a role.
Meeting Abstract
Ophthalmology
S. B. A. Mokhtar, F. C. T. van der Heide, K. A. M. Oyaert, C. J. H. van der Kallen, T. T. J. M. Berendschot, F. Scarpa, A. Colonna, B. E. de Galan, M. M. J. van Greevenbroek, C. G. Schalkwijk, R. M. M. A. Nuijts, M. T. Schram, C. A. B. Webers, C. D. A. Stehouwer
ACTA OPHTHALMOLOGICA
(2023)
Meeting Abstract
Endocrinology & Metabolism
Veerle van Hulten, Cindy Sarodnik, Johanna Driessen, Sandrine Bours, Nicklas Rasmussen, Rikke Viggers, Nicolaas Schaper, Annemarie Koster, Marleen van Greevenbroek, Carla van der Kallen, Coen Stehouwer, Joop van den Bergh
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Hematology
B. Wauben, M. W. M. van der Poel, M. M. J. Greevenbroek, N. C. van Yperen, M. T. Schram, M. P. J. van Boxtel, M. Sastry, S. O. Simons, C. D. A. Stehouwer, P. C. Dagnelie, A. Wesselius, H. C. Schouten, S. Kohler
Summary: Although cognitive problems can recover over time, a subgroup of hematopoietic stem cell transplantation (HCT) survivors experience persistent cognitive problems in the long term. The aim of this study was to quantify the prevalence of cognitive impairment in HCT survivors and identify potential determinants of cognitive functioning within this group. Cognitive performance was assessed using a neuropsychological test battery divided into three domains: memory, information processing speed, and executive function and attention.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Geriatrics & Gerontology
April C. E. van Gennip, Miranda Schram, Sebastian Kohler, Abraham A. Kroon, Annemarie Koster, Simone J. P. M. Eussen, Bastiaan E. de Galan, Thomas T. van Sloten, Coen D. A. Stehouwer
Summary: This study examined the incidence of major depression and clinically relevant depressive symptoms among individuals with type 2 diabetes, based on the number of risk factors within the recommended target range. The study found that the risk of depression decreased stepwise with an increasing number of risk factors within the recommended target range in individuals with type 2 diabetes. Therefore, this study provides evidence to promote risk factor modification strategies and the adoption of a healthy lifestyle in individuals with type 2 diabetes.
LANCET HEALTHY LONGEVITY
(2023)
