Journal
INVESTIGATIONAL NEW DRUGS
Volume 39, Issue 3, Pages 871-878Publisher
SPRINGER
DOI: 10.1007/s10637-021-01063-z
Keywords
Breast cancer; Gut microbiota; Homeostasis; Novel therapy
Categories
Funding
- National Natural Science Foundation of China [81872412]
- Innovation Fund Designated for Graduate Students of Yangtze University Health Science Center [2020007]
Ask authors/readers for more resources
This article discusses how gut microbiota can affect the development of breast cancer and the types of bacteria that may be involved. In addition, potential therapies to reduce the risk of breast cancer, such as restoring gut microbiota homeostasis and reducing systemic estrogen levels, are described.
Breast cancer is the most diagnosed cancer in women. It significantly impairs a patient's physical and mental health. Gut microbiota comprise the bacteria residing in a host's gastrointestinal tract. Through studies over the last decade, we now know that alterations in the composition of the gut microbiome are associated with protection against colonization by pathogens and other diseases, such as diabetes and cancer. This review focuses on how gut microbiota can affect breast cancer development through estrogen activity and discusses the types of bacteria that may be involved in the onset and the progression of breast cancer. We also describe potential therapies to curtail the risk of breast cancer by restoring gut microbiota homeostasis and reducing systemic estrogen levels. This review will further explore the relationship between intestinal microbes and breast cancer and propose a method to treat breast cancer by improving intestinal microbes. We aimed at discovering new methods to prevent or treat BC by changing intestinal microorganisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available