Article
Radiology, Nuclear Medicine & Medical Imaging
Salim Benhmida, Amandine Beneux, Corina Udrescu, Olivier Rouviere, Samy Horn, Ciprian Enachescu, Ariane Lapierre, Olivier Chapet
Summary: The study evaluated the dosimetric feasibility of a 5 x 9 Gy SBRT regimen for prostate cancer while limiting the dose to the urethra. Results showed that this treatment approach is feasible without compromising dose coverage to the tumor.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Review
Oncology
Megan E. Daly
Summary: Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable, early-stage non-small-cell lung cancer. However, regional and distant failures remain a challenge, especially in larger and more biologically aggressive tumors. Use of cytotoxic chemotherapy is limited in this patient population, prompting the investigation of alternative systemic therapy options with fewer side effects, such as immune checkpoint inhibitors.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Physical
M. Savanovic, D. Jaros, P. Chauchat, J. N. Foulquier
Summary: The study evaluated absolute dose in lung SBRT between phase- and amplitude-gated modes using in-house developed moving targets. Results showed that the microDiamond detector had the lowest dose discrepancy in phase-gated mode, while the Pinpoint ion chamber had lower discrepancy in amplitude-gated mode, and the Semiflex ion chamber showed the greatest discrepancy.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Oncology
Lily Chen, Bhavani S. Gannavarapu, Neil B. Desai, Michael R. Folkert, Michael Dohopolski, Ang Gao, Chul Ahn, Jeffrey Cadeddu, Aditya Bagrodia, Solomon Woldu, Ganesh V. Raj, Claus Roehrborn, Yair Lotan, Robert D. Timmerman, Aurelie Garant, Raquibul Hannan
Summary: This study analyzed the use of stereotactic ablative radiation (SAbR) at a dose of 45 Gy in 5 fractions for prostate cancer. The results showed promising safety profiles, but further prospective studies are needed to establish this dose regimen as standard of care.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Indu S. Voruganti, Ian Poon, Zain A. Husain, Andrew Bayley, Elizabeth A. Barnes, Liying Zhang, Lee Chin, Darby Erler, Kevin Higgins, Danny Enepekides, Antoine Eskander, Irene Karam
Summary: This study reported the outcomes of SBRT for head and neck skin cancer patients, including local control, overall survival, and late toxicity. The results showed that SBRT provides durable disease control with acceptable toxicity for high-risk patients unable to undergo standard treatment approaches.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
David Pasquier, Thomas Lacornerie, Stephane Supiot, Pascal Pommier, Magali Quivrin, Jean-Marc Simon, Genevieve Loos, Emmanuel Meyer, Gilles Calais, Didier Peiffert, Benjamin Vandendorpe, Estelle Aymes, Clemence Leguillette, Meryem Brihoum, Soazig Nenan, Luc Cormier, Marie-Cecile Le Deley, Eric F. Lartigau
Summary: This study explored the optimal dose regimen for salvage SBRT in prostate cancer recurrence patients. The results showed that a 6 x 6 Gy dose regimen was selected for a phase 2 study, and the level of toxicity appears to be acceptable in the short term.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Review
Oncology
Zarique Z. Akanda, Paul J. Neeson, Thomas John, Stephen Barnett, Gerard G. Hanna, Alistair Miller, Ross Jennens, Shankar Siva
Summary: ICIs have improved overall survival in m-NSCLC, but resistance is a challenge. Combining ICIs with other treatments to modulate the TME and sensitize tumours is promising. Further investigation is needed for optimal combinations, dosing, and sequencing of ICI + SABR in m-NSCLC.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Casey Moore, Ching-Cheng Hsu, Wei-Min Chen, Benjamin P. C. Chen, Chuanhui Han, Michael Story, Todd Aguilera, Laurentiu M. Pop, Raquibul Hannan, Yang-Xin Fu, Debabrata Saha, Robert Timmerman
Summary: Combining radiation with immunotherapy can harness immune-stimulatory effects for better tumor treatment outcomes. Factors such as immunotherapy and radiation dose sequencing, as well as radiation fraction spacing, impact the response to combination therapy. Personalized PULSAR-style radiation dosing shows better tumor control in this model, emphasizing the importance of preclinical investigation in designing clinical trials for combination therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Yan-Jun Xiang, Kang Wang, Yi-Tao Zheng, Shuang Feng, Hong-Ming Yu, Xiao-Wei Li, Xi Cheng, Yu-Qiang Cheng, Jin-Kai Feng, Li-Ping Zhou, Yan Meng, Jian Zhai, Yun-Feng Shan, Shu-Qun Cheng
Summary: This study demonstrates that SBRT combined with PD-1 inhibitors can improve clinical outcomes, including PFS, OS, and tumor response, in patients with intermediate-stage HCC who are refractory to TACE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Khaled Dibs, Dukagjin M. Blakaj, Rahul N. Prasad, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Evan Thomas, Hyeri Lee, John Grecula, Raju R. Raval, Ehud Mendel, Thomas Scharschmidt, Russell Lonser, Arnab Chakravarti, James B. Elder, Joshua D. Palmer
Summary: Spine SBRT treatment for patients with >= 3 contiguous involved levels is feasible and may offer excellent local control without significant toxicity. Prospective evaluation is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Khaled Dibs, Joshua D. D. Palmer, Rahul N. N. Prasad, Alexander Olausson, Eric C. C. Bourekas, Daniel Boulter, Ahmet S. S. Ayan, Eric Cochran, William S. S. Marras, Prasath Mageswaran, Evan Thomas, John Grecula, Michael Guiou, Soheil Soghrati, Esmerina Tili, Raju R. R. Raval, Ehud Mendel, Thomas Scharschmidt, James B. B. Elder, Russell Lonser, Arnab Chakravarti, Dukagjin M. M. Blakaj
Summary: Circumferential spine SBRT is feasible and may offer excellent local control without significant toxicity for patients with circumferential disease. Prospective evaluation of this approach is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ulrike Bauer, Sabine Gerum, Falk Roeder, Stefan Muench, Stephanie E. Combs, Alexander B. Philipp, Enrico N. De Toni, Martha M. Kirstein, Arndt Vogel, Carolin Mogler, Bernhard Haller, Jens Neumann, Rickmer F. Braren, Marcus R. Makowski, Philipp Paprottka, Markus Guba, Fabian Geisler, Roland M. Schmid, Andreas Umgelter, Ursula Ehmer
Summary: This study aimed to analyze histopathological response in patients with HCC who underwent TACE and SBRT combination therapy compared to those who received TACE or SBRT alone. The results showed that the combination therapy group had a higher rate of complete histopathological response, with almost all patients (8/9, 89%) showing no residual vital tumor tissue, compared to significantly lower rates in the TACE or SBRT alone groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S. Lo, Ursula Nestle, Nils H. Nicolay, Gabriele Niedermann, Dan G. Duda, Anca-L. Grosu
Summary: We conducted a prospective study to investigate the changes in circulating immune cells after stereotactic body radiotherapy (SBRT) in early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at the first follow-up, but observed a significant expansion in Ki-67(+)CD8(+) and Ki-67(+)CD4(+) T-cell fractions in patients receiving 10 Gy or less per fraction. Our findings suggest that SBRT can induce immediate expansion of circulating effector T-cells.
NPJ PRECISION ONCOLOGY
(2023)
Article
Urology & Nephrology
Edmond M. Kwan, Lavinia Spain, Angelyn Anton, Chun L. Gan, Linda Garrett, Deborah Chang, Elizabeth Liow, Caitlin Bennett, Tiantian Zheng, Jianjun Yu, Chao Dai, Pan Du, Shidong Jia, Heidi Fettke, Claire Abou-Seif, Gargi Kothari, Mark Shaw, Phillip Parente, Carmel Pezaro, Ben Tran, Shankar Siva, Arun A. Azad
Summary: This study evaluated the efficacy and safety of combining the PD-L1 inhibitor avelumab with stereotactic ablative body radiotherapy (SABR) in metastatic castration-resistant prostate cancer (mCRPC). The results showed that this combination demonstrated encouraging activity and acceptable toxicity in treatment-refractory mCRPC, suggesting the potential for further investigations.
Article
Oncology
Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso, Richard De Abreu Lourenco, Tomas Kron, David Ball, Paul Neeson
Summary: This study aimed to compare the treatment efficacy of single-fraction and multifraction SABR for pulmonary oligometastases, and the results showed no significant differences in safety, efficacy, or symptom burden between the two approaches, with single-fraction SABR being more efficient for delivery.
Article
Peripheral Vascular Disease
Marieke van den Kerkhof, Merel M. van der Thiel, Alida A. Postma, Robert J. van Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Summary: This study found that patients with hypertension have higher pulsatility index (PI) and lower damping factor (DF) in small perforating arteries, which may be due to hypertension-induced arterial stiffening leading to increased blood flow pulsatility and decreased damping. These results highlight the impact of hypertension on cerebral blood vessel structure and function, and provide clues for further investigation into the relationship between hypertension and stroke and cerebral small vessel disease (cSVD).
Article
Endocrinology & Metabolism
Marieke van den Kerkhof, Merel M. van der Thiel, Robert J. van Oostenbrugge, Alida A. Postma, Abraham A. Kroon, Walter H. Backes, Jacobus F. A. Jansen
Summary: Arterial walls become stiffer with age, cardiovascular risk factors, and various vascular diseases, leading to decreased damping of the arterial blood flow pulse, microvascular damage, and enlarged perivascular spaces (PVS). However, the exact relationship between these processes is unclear.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Oncology
Erich P. Huang, James P. B. O'Connor, Lisa M. McShane, Maryellen L. Giger, Philippe Lambin, Paul E. Kinahan, Eliot L. Siegel, Lalitha K. Shankar
Summary: Integration of computer-extracted tumour characteristics into medical imaging computer-aided diagnosis (CAD) algorithms has been a long-standing practice. However, the translation of radiomics, an extension of CAD involving quantitative characterization of healthy or pathological structures and processes captured by medical imaging, into clinically useful tools has been limited. This may be due to factors such as varying imaging and radiomic feature extraction protocols, potential pitfalls in radiomic data analysis, and a lack of evidence demonstrating the clinical benefit of radiomic-based tools. The authors provide 16 criteria to guide the clinical translation of radiomics, with the aim of accelerating the use of this technology to improve patient outcomes.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Ilse Huijberts, Florentina M. E. Pinckaers, Wim H. van Zwam, Hieronymus D. Boogaarts, Robert J. van Oostenbrugge, Alida A. Postma
Summary: This study investigated the incidence and predictors of cerebral arterial air emboli (CAAE) on immediate post endovascular treatment (EVT) dual-energy CT (DECT) in acute ischemic stroke (AIS) patients, and described their association with clinical outcomes. The presence and number of linear CAAE, but not circular CAAE, were found to be associated with unfavorable short- and long-term clinical outcomes.
JOURNAL OF NEURORADIOLOGY
(2023)
Review
Dermatology
Y. Widaatalla, T. Wolswijk, F. Adan, L. M. Hillen, H. C. Woodruff, I. Halilaj, A. Ibrahim, P. Lambin, K. Mosterd
Summary: Basal cell carcinoma (BCC) is a common type of cancer, and the application of artificial intelligence techniques for detecting and classifying BCC is necessary. This article reviews the current evidence on the use of handcrafted and deep radiomics models for BCC detection and classification in dermoscopy, optical coherence tomography, and reflectance confocal microscopy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Susanne G. H. Olthuis, F. Anne Pirson, Florentina M. E. Pinckaers, Wouter H. Hinsenveld, Daan Nieboer, Angelique Ceulemans, Robrecht R. M. M. Knapen, M. M. Quirien Robbe, Olvert A. Berkhemer, Marianne A. A. van Walderveen, Geert J. Lycklama a Nijeholt, Maarten Uyttenboogaart, Wouter J. Schonewille, P. Matthijs van der Sluijs, Lennard Wolff, Henk van Voorst, Alida A. Postma, Stefan Roosendaal, Anouk van der Hoorn, Bart J. Emmer, Menno G. M. Krietemeijer, Pieter-Jan van Doormaal, Bob Roozenbeek, Robert-Jan B. Goldhoorn, Julie Staals, Inger R. de Ridder, Christiaan van der Leij, Jonathan M. Coutinho, H. Bart van der Worp, Rob T. H. Lo, Reinoud P. H. Bokkers, Ewoud Ivan Dijk, Hieronymus Boogaarts, Marieke J. H. Wermer, Adriaan C. G. M. van Es, Julia H. van Tuijl, Hans G. J. Kortman, Rob A. R. Gons, Lonneke S. F. Yo, Jan-Albert Vos, Karlijn F. de Laat, Lukas C. van Dijk, Ido R. van den Wijngaard, Jeannette Hofmeijer, Jasper M. Martens, Paul J. A. M. Brouwers, Tomas Bulut, Michel J. M. Remmers, Thijs E. A. M. de Jong, Heleen M. den Hertog, Boudewijn A. A. M. van Hasselt, Anouk Rozeman, Otto E. H. Elgersma, Bas van der Veen, Davy R. Sudiono, Hester F. Lingsma, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Aad van der Lugt, Diederik W. J. Dippel, Wim H. van Zwam, Robert J. van Oostenbrugge
Summary: The MR CLEAN-LATE trial aimed to assess the efficacy and safety of endovascular treatment for patients with late window anterior circulation ischaemic stroke selected based on collateral flow on CT angiography. The study showed that endovascular treatment was effective and safe for patients with anterior circulation large-vessel occlusion who presented within 6-24 hours from symptom onset or last seen well and were selected based on the presence of collateral flow on CTA.
Article
Clinical Neurology
Jan W. Hoving, Henk van Voorst, Daan Peerlings, Jasper D. Daems, Miou S. Koopman, Anke Wouters, Manon Kappelhof, Natalie E. LeCouffe, Kilian M. Treurniet, Agnetha A. E. Bruggeman, Leon A. Rinkel, Ido R. van den Wijngaard, Jonathan M. Coutinho, Aad van der Lugt, Henk A. Marquering, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Bart J. Emmer, MR CLEAN NO IV Investigators
Summary: In this study, the effectiveness of IVT prior to EVT in acute ischemic stroke patients was found to be not significantly different when considering CT perfusion-based imaging parameters.
Article
Radiology, Nuclear Medicine & Medical Imaging
Manon P. L. Beuque, Marc B. I. Lobbes, Yvonka van Wijk, Yousif Widaatalla, Sergey Primakov, Michael Majer, Corinne Balleyguier, Henry C. Woodruff, Philippe Lambin
Summary: This study developed a comprehensive machine learning tool that can automatically identify, segment, and classify breast lesions on contrast-enhanced mammography (CEM) images in recall patients. The results showed that the combined output of the handcrafted radiomics and deep learning models achieved good diagnostic performance in lesion identification and classification, outperforming the individual models.
Article
Clinical Neurology
Nadinda A. M. van der Ende, Sven P. R. Luijten, Leo Kluijtmans, Alida A. Postma, Sandra A. Cornelissen, Antonius M. G. van Hattem, Geert J. Nijeholt, Reinoud P. H. Bokkers, Lars Thomassen, Ulrike Waje-Andreassen, Nicola Logallo, Serge Bracard, Benjamin Gory, Bob Roozenbeek, Diederik W. J. Dippel, Aad van der Lugt
Summary: This study assessed the interobserver agreement on the presence and types of intracranial hemorrhage (ICH) in patients treated with reperfusion therapy using magnetic resonance imaging. The results showed that the presence of any ICH can be reliably scored on magnetic resonance imaging, and there is substantial agreement on the types of ICH according to the Heidelberg Bleeding Classification.
Article
Oncology
Zohaib Salahuddin, Yi Chen, Xian Zhong, Henry C. Woodruff, Nastaran Mohammadian Rad, Shruti Atul Mali, Philippe Lambin
Summary: Automatic delineation and detection of primary tumour (GTVp) and lymph nodes (GTVn) in head and neck cancer using PET and CT can help diagnose and stratify patient risk. This study utilized data from nine centres and developed a segmentation model that estimated uncertainty for false positive reduction. Radiomics features extracted from GTVp and GTVn in PET and CT were found to be prognostic for recurrence-free survival prediction. The framework incorporated uncertainty estimation, fairness, and explainability.
Article
Imaging Science & Photographic Technology
Rihab Hami, Sena Apeke, Pascal Redou, Laurent Gaubert, Ludwig J. Dubois, Philippe Lambin, Dimitris Visvikis, Nicolas Boussion
Summary: The effectiveness of radiotherapy depends on various factors, and the tumor response to radiation varies among patients. This study developed a multi-scale model that integrated five major biological concepts in radiotherapy to predict the effects of radiation on tumor growth. The model considered factors such as oxygen level, cell cycle position, cellular sensitivity, and repair, providing a basis for a more personalized clinical tool.
JOURNAL OF IMAGING
(2023)
Article
Clinical Neurology
Sven P. R. Luijten, Nadinda A. M. van der Ende, Sandra A. P. Cornelissen, Leo Kluijtmans, Antonius van Hattem, Geert Nijeholt, Alida A. Postma, Reinoud P. H. Bokkers, Lars Thomassen, Ulrike Waje-Andreassen, Nicola Logallo, Serge Bracard, Benjamin Gory, Bob Roozenbeek, Diederik W. J. Dippel, Aad van der Lugt
Summary: This study compared the diagnostic accuracy of diffusion-weighted imaging (DWI) b0 with T2*-weighted gradient echo (GRE) or susceptibility-weighted imaging (SWI) for detection of hemorrhage in ischemic stroke patients after reperfusion therapy. The results showed that DWI b0 had lower sensitivity for detecting hemorrhage, especially for smaller and more subtle hemorrhages. Therefore, follow-up MRI protocols should include T2*GRE or SWI for detection of hemorrhage after reperfusion therapy.
Article
Microbiology
Yanchao Zhang, Aleksandra M. Kubiak, Tom S. Bailey, Luuk Claessen, Philip Hittmeyer, Ludwig Dubois, Jan Theys, Philippe Lambin
Summary: Clostridium species have gained attention in industrial and medical applications, with the development of genetic tools enabling the advancement of the CRISPR-Cas systems. This study demonstrated the establishment of a CRISPR-Cas12a system in clostridia with two different cas12a genes, allowing for efficient and rapid genome modification. The results showed that the CRISPR-FnCas12a system offers flexible target selection in clostridia, with a specific folding pattern of the precursor crRNA being important for high mutation generation efficiency.
MICROBIOLOGY SPECTRUM
(2023)
Article
Clinical Neurology
Vicky Chalos, Esmee Venema, Maxim J. H. L. Mulder, Bob Roozenbeek, Ewout W. Steyerberg, Marieke J. H. Wermer, Geert J. Lycklama A. Nijeholt, H. Bart van der Worp, Mayank Goyal, Bruce C. V. Campbell, Keith W. Muir, Francis Guillemin, Serge Bracard, Philip White, Antoni Davalos, Tudor G. Jovin, Michael D. Hill, Peter J. Mitchell, Andrew M. Demchuk, Jeffrey L. Saver, Aad van der Lugt, Scott Brown, Diederik W. J. Dippel, Hester F. Lingsma
Summary: This study developed and validated a model to predict functional outcome for individual patients after endovascular treatment (EVT) for ischemic stroke. The model showed good discrimination and calibration in predicting functional independence and survival. It can be applied 1 day after EVT to provide accurate outcome expectations and personalize follow-up and rehabilitation plans.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zaid Al-Difaie, Max H. M. C. Scheepers, Nicole D. Bouvy, Sanne Engelen, Bas Havekes, Alida A. Postma
Summary: This study evaluated the feasibility of virtual non-contrast (VNC) images in the neck region and found that VNC images had acceptable agreement with true non-contrast (TNC) images in most anatomical structures, except for the thyroid. Therefore, VNC images may have the potential to replace TNC images in the neck, but not for thyroid imaging.
ACTA RADIOLOGICA OPEN
(2023)
