Review
Engineering, Biomedical
Dishary Banerjee, Yogendra Pratap Singh, Pallab Datta, Veli Ozbolat, Aaron O'Donnell, Miji Yeo, Ibrahim T. Ozbolat
Summary: Biofabricated tissues have versatile applications in tissue engineering and regenerative medicine, as well as disease modeling and drug development and screening. Spheroid bioprinting has emerged as a crucial tool for assembling and organizing multiple types of cells into physiologically and histologically relevant tissues.
Review
Engineering, Biomedical
Pei Zhuang, Yi-Hua Chiang, Maria Serafim Fernanda, Mei He
Summary: Although cancer remains a leading cause of mortality worldwide, efforts in anticancer therapeutics are hindered by the lack of robust prediction models. Multicellular tumor spheroids, a popular three-dimensional culture model for avascular tumors, have limitations in controlling cellular and structural organization. 3D bioprinting, with its spatial control, scalability, and reproducibility, holds promise for generating more faithful tumor models and advancing our understanding of tumor progression.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Review
Engineering, Biomedical
Ming Li, Xueer Song, Sha Jin, Kaiming Ye
Summary: This review highlights the use of three-dimensional tumor models in cancer pathology studies and drug discovery, which can simulate the complex human tumor microenvironment. Various biofabrication technologies, including 3D bioprinting techniques, are discussed for characterizing tumor progression and response to treatment.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Engineering, Biomedical
Lise De Moor, Jasper Smet, Magalie Plovyt, Bieke Bekaert, Chris Vercruysse, Mahtab Asadian, Nathalie De Geyter, Sandra Van Vlierberghe, Peter Dubruel, Heidi Declercq
Summary: This study explored the potential and feasibility of using spheroids containing capillary-like networks as prevascularized units for integration into the entire bioprinted construct.
Article
Biotechnology & Applied Microbiology
Christopher David Roche, Poonam Sharma, Anthony Wayne Ashton, Chris Jackson, Meilang Xue, Carmine Gentile
Summary: This study evaluated 3D bioprinted cardiac patches using AlgGel hydrogels, finding key factors affecting durability included the number of layers, movement disturbance during culture, and the addition of extracellular matrix. The cells in the patches remained viable after bioprinting and during culture, with endothelial cells able to self-organize into network-like structures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Quan Li, Guangyan Qi, Xuming Liu, Jianfa Bai, Jikai Zhao, Guosheng Tang, Yu Shrike Zhang, Ruby Chen-Tsai, Meng Zhang, Donghai Wang, Yuanyuan Zhang, Anthony Atala, Jia-Qiang He, Xiuzhi Susan Sun
Summary: A universal peptide hydrogel is used to manufacture hiPSC spheroids, demonstrating excellent biocompatibility and superior biological properties. This method can be applied in the fields of tissue engineering and organ regeneration for physiologically formed structures.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Food Science & Technology
Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu, Xiaoyun Xu
Summary: This study found that certain flavonoids can effectively reverse multidrug resistance mediated by P-glycoprotein (P-gp) by inhibiting its activity, with specific structural groups and substitutions playing a crucial role in their inhibitory effects. Additionally, flavonoids can impact P-gp ATPase activity and expression levels, thereby influencing its drug transport activity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Summary: In this study, the researchers investigated the effect of the CDK4/6 inhibitor, ribociclib, on multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) in human epidermoid carcinoma cells. They found that ribociclib increased the efficacy of a P-gp substrate drug, colchicine, by down-regulating the expression of P-gp and increasing its ATPase activity. Docking studies suggested that ribociclib interacted with the drug-substrate binding site of P-gp. Additionally, ribociclib inhibited the drug efflux activity of P-gp, leading to increased intracellular accumulation of doxorubicin. These findings suggest that ribociclib may be a potential agent for combined therapy in cancers with P-gp-mediated MDR.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bruna A. G. de Melo, Julia C. Benincasa, Elisa M. Cruz, Juliana Terzi Maricato, Marimelia A. Porcionatto
Summary: The pandemic caused by SARS-CoV-2 has led to over a million deaths globally, prompting the scientific community to study the virus's infection mechanisms and develop new vaccines and therapies. Tissue engineering strategies, specifically 3D models, offer advantages over traditional cell cultures in virology studies, providing more realistic models for research on COVID-19. Scaffold-free and scaffold-based approaches in biofabrication allow for the creation of physiologically relevant models for the development of treatments against the virus.
BIOMEDICAL JOURNAL
(2021)
Review
Chemistry, Medicinal
Hang Zhang, Haiwei Xu, Charles R. Ashby, Yehuda G. Assaraf, Zhe-Sheng Chen, Hong-Min Liu
Summary: This review highlights the recent achievements in drug design and mechanism studies of newly synthetic P-gp inhibitors in the past 5 years, which will help overcome multidrug resistance in cancer chemotherapy.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Cell Biology
Niraimathi Govindasamy, Hongyan Long, Hyun-Woo Jeong, Ratish Raman, Burak Ozcifci, Simone Probst, Sebastian J. Arnold, Kristina Riehemann, Adrian Ranga, Ralf H. Adams, Britta Trappmann, Ivan Bedzhov
Summary: This study established a 3D biomimetic culture environment mimicking the murine implantation niche, allowing for direct analysis of trophoblast invasion and early interactions with maternal vasculature. The findings reveal that implantation is mediated by collective migration of trophoblast giant cells, which acquire expression of vascular receptors and adhesion molecules to communicate with maternal blood vessels, with Pdgf signaling playing a key role in establishing heterologous contacts.
DEVELOPMENTAL CELL
(2021)
Article
Chemistry, Medicinal
Laura Braconi, Silvia Dei, Marialessandra Contino, Chiara Riganti, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Maria Grazia Perrone, Nicola Antonio Colabufo, Stefano Guglielmo, Elisabetta Teodori
Summary: New 2,5- and 1,5-disubstituted tetrazoles, and 2,5-disubstituted-1,3,4-oxadiazoles were synthesized and studied as MDR reversers, showing potent inhibitory effects on P-gp transport activity and increasing the antiproliferative effect of doxorubicin in MDR cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Giulia Vanti, Marcella Coronnello, Daniele Bani, Antonella Mannini, Maria Camilla Bergonzi, Anna Rita Bilia
Summary: The co-delivery of the P-gp inhibitor tariquidar and the cytotoxicity inducer berberine chloride using nanoliposomes shows promise in overcoming multidrug resistance by effectively reversing it and significantly increasing drug accumulation in tumor cells, potentially resensitizing resistant cells to anticancer agents.
Article
Medicine, Research & Experimental
Camila Albuquerque Pinto, Adrhyann Jullyanne de Sousa Portilho, Maritza Cavalcante Barbosa, Maria Elisabete Amaral De Moraes, Jose Alexandre Rodrigues De Lemos, Rommel Mario Rodriguez Burbano, Caroline Aquino Moreira-nunes
Summary: The combined therapy of ATRA and IM showed significant decrease in BCR-ABL and ABCB1 gene expression, possibly through differentiation of blast cells. This suggests that the therapy could be effective for blast crisis and CML patients resistant to current treatments.
Article
Cell Biology
Hannes Horder, Mar Guaza Lasheras, Nadine Grummel, Ali Nadernezhad, Johannes Herbig, Sueleyman Erguen, Joerg Tessmar, Juergen Groll, Ben Fabry, Petra Bauer-Kreisel, Torsten Blunk
Summary: Biofabrication, including 3D printing technologies, is a powerful approach for designing disease models, such as in cancer research. A 3D-printed breast cancer model was developed to investigate cancer cell-adipocyte interaction, demonstrating adipogenic differentiation within printed spheroids. Co-culture of breast cancer cells with adipose tissue constructs showed reduced lipid content and ECM remodeling, highlighting the importance of cell-cell and cell-matrix interplay within tumor-stroma microenvironment.
Article
Multidisciplinary Sciences
Asif Jan, Amina Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz
Summary: Genome-wide association studies have revealed T2DM risk variants in European populations, but there is a lack of such studies in Pakistan. This study focused on the Pashtun ethnic population and identified several genetic risk variants associated with T2DM through exome sequencing and genotyping.
Article
Agronomy
Luqman Muhammad, Salahuddin Salahuddin, Asif Khan, Yunwei Zhou, Miao He, Abdulwahed Fahad Alrefaei, Murtaza Khan, Sajid Ali
Summary: The tolerance response of four chrysanthemum cultivars to different cadmium concentrations was investigated. The study found that cadmium significantly inhibited chlorophyll and carotenoid synthesis in all cultivars. Furthermore, ultrastructure changes were observed in the cells under cadmium stress.
Article
Mathematics, Applied
Mairaj Bibi, Sajid Ali, Muhammad Shoaib Arif, Kamaleldin Abodayeh
Summary: In [1], Bibi and Edjvet demonstrated that any equation with a length of at most seven over torsion-free group can be solved. This supports Levin's [2] assertion that any equation over a torsion-free group is solvable. This article demonstrates that a singular equation of length eight over torsion-free groups is solvable.
Article
Business, Finance
Yue Sheng Chen, Zhong Chen, Sajid Ali, Muhammad Imdad Ullah, Muhammad Khalid Anser
Summary: This research investigates the impact of financial inclusion on foreign direct investment (FDI) in East Asia and Pacific (EAP) countries. Traditional econometric methods fail to consider cross-sectional dependence and heterogeneity among countries, leading to biased estimates. Using the unique method called DCCE, the study finds that financial inclusion positively and significantly affects FDI in higher-income and overall EAP countries. In lower-income EAP countries, financial inclusion has an insignificant correlation with FDI, which becomes significant when an interaction term for institutional performance and financial inclusion is included. Therefore, policymakers should focus on increasing financial inclusion to attract FDI and promote economic growth in EAP economies.
BORSA ISTANBUL REVIEW
(2023)
Article
Green & Sustainable Science & Technology
Zareen Zuhra, Yasir Abbas, Shafqat Ali, Shuo Li, Guanqun Xie, Xiaoxia Wang
Summary: A magnetic hybrid material based on Cu-pPDA MOF and Fe3O4 nanosphere was designed for selective recovery of Au(III) and Pd(II) from e-waste, and was converted into carbon-supported FeAu and FePd nanoparticles catalysts. The FeAu/C catalyst exhibited higher conversion rate of cyclohexane compared to the FePd/C catalyst.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Pharmacology & Pharmacy
Nida Shakir, Ali Sharif, Sajid Ali, Bushra Akhtar, Muhammad Furqan Akhtar, Faqir Muhammad, Ammara Saleem, Kanwal Akhtar, Imran Tariq, Muhammad Imran Khan
Summary: This study evaluated the acute and chronic toxicity of Pirarubicin loaded PLGA nanoparticles (PRB-NP). The nanoparticles did not affect the behavioral pattern, food, water consumption or body weights of the rats. The abnormalities in function and morphology of the organs produced by PRB-NP were dose-dependent and reversible.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Hasan Sardar, Muhammad Arif Ramzan, Safina Naz, Sajid Ali, Shaghef Ejaz, Riaz Ahmad, Muhammad Ahsan Altaf
Summary: Salt accumulation in irrigated soils is a worldwide hazard that affects crop productivity. Broccoli is moderately tolerant to salinity. The application of exogenous melatonin improved the morphological characteristics and biochemical composition of broccoli under salt stress.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Biochemistry & Molecular Biology
Sajid Ali, Pierre Gladieux, Sebastien Ravel, Henri Adreit, Isabelle Meusnier, Joelle Milazzo, Sandrine Cros-Arteil, Francois Bonnot, Baihui Jin, Thomas Dumartinet, Florian Charriat, Alexandre Lassagne, Xiahong He, Didier Tharreau, Huichuan Huang, Jean-Benoit Morel, Elisabeth Fournier
Summary: By investigating the genetic and phenotypic relationship between rice landraces and their rice blast pathogen in traditional flooded rice paddies, it was found that specific lineages of rice blast coexisted in the Yuanyang terraces. The study suggests that disease control strategies based on the emergence or maintenance of a generalist lifestyle in pathogens may sustainably reduce the burden of disease in crops.
Article
Environmental Sciences
Meilan Chen, Wenfeng Huang, Sajid Ali
Summary: Renewable energy is gaining popularity due to its cost-effectiveness. This study examines the asymmetric link between wind energy and ecological footprint in the top-10 wind energy-consumer economies. The results show that wind energy consumption reduces ecological footprint in most sample nations, except for Spain and India. The degree of the asymmetric association varies by country, highlighting the need for individualized government policies in promoting wind energy and ecological sustainability.
ENVIRONMENTAL DEVELOPMENT
(2023)
Article
Agronomy
Nighat Seema, Muhammad Hamayun, Anwar Hussain, Mohib Shah, Muhammad Irshad, Muhammad Qadir, Amjad Iqbal, Abdulwahed Fahad Alrefaei, Sajid Ali
Summary: The aim of this study was to isolate endophytes from the roots of Rhazya stricta and evaluate their potential in improving the growth of drought-stressed sunflower seedlings. The isolated endophytic fungus was found to enhance the growth attributes of rice varieties and contribute to the improvement of sunflower growth under drought stress. The fungal strain was identified as Fusarium proliferatum and its beneficial effects were attributed to the regulation of phytohormones and stress-related metabolites.
Article
Agronomy
Muhammad Musa, Farzana Gul Jan, Muhammad Hamayun, Gul Jan, Sumera Afzal Khan, Gauhar Rehman, Sajid Ali, In-Jung Lee
Summary: Heavy metal contamination in soil and accumulation in plants pose a serious threat to crops and human health. Endophytic fungi can enhance the plant's ability to tolerate stressful conditions. The present study found that the endophytic fungus Paecilomyces lilacinus (MRF) isolated from the roots of Justicia adathoda has the capability to alleviate heavy metal stress and improve the growth and physiological characteristics of tomatoes.
Article
Physics, Particles & Fields
Sajid Ali, Georg Bergner, Camilo Lopez, Istvan Montvay, Gernot Muenster, Stefano Piemonte
Summary: We extend our analysis of bound states in N = 1 supersymmetric Yang-Mills theory by considering baryonic operators composed of three gluino fields. These states are similar to baryons in QCD, but their properties and the fermion line contractions involved in their correlation functions are different due to the difference between gluino and quark fields. In this work, we explain the derivation of these operators and the contractions needed in numerical calculations of their correlators, and provide an initial estimate of the two-point function and the mass of the lightest baryonic state in N = 1 supersymmetric Yang-Mills theory.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Review
Chemistry, Multidisciplinary
Shujat Ali, Xi Chen, Shujaat Ahmad, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani, Zarif Gul, Abid Ullah, Haya Hussain, Limin Li, Xiaojing Chen
Summary: Gold bimetallic nanostructures (AuBMNS) show better Hg sensing activity than their monometallic counterparts and their performance depends on shape, size, composition, and surface chemistry. However, there is a lack of review papers on the morphology-controlled synthesis of AuBMNS and their application in Hg detection. This article aims to provide a clear understanding of the shape/size-controlled preparation, functionalization, and morphology-dependent application of AuBMNS in Hg detection.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Sun Guoyan, Asadullah Khaskheli, Syed Ali Raza, Sajid Ali
Summary: According to the United Nations Agenda, a sustainable environment is crucial for the future of the planet in 2023, and investment in energy through public-private partnerships is essential for sustainable development. The research examines the relationship between public-private partnership ventures in energy and environmental degradation in ten developing nations. The findings show a positive association in Argentina, Brazil, Bangladesh, and India, while a negative relationship is observed in China, Malaysia, Mexico, Peru, Thailand, and the Philippines.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Afshan Asghar, Ali Sharif, Sana Javaid Awan, Bushra Akhtar, Muhammad Furqan Akhtar, Sajid Ali, Shahnaz
Summary: This study investigated the anti-diabetic effects of the ethanolic extract of Ficus johannis leaves and found that it exhibited strong antioxidant and alpha-amylase inhibitory activities. The extract contained high levels of phenolic and flavonoid compounds, with gallic acid being the main constituent. Animal experiments showed that the extract improved insulin sensitivity, glucose transporter 4 translocation, and carbohydrate metabolism, while inhibiting lipogenesis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)