Article
Biophysics
Nafiseh Zahabi, Mohammad-Taghi Golmakani, Mahboubeh Fazaeli, Fatemeh Ghiasi, Mohammadreza Khalesi
Summary: This study successfully fabricated nanofibers from barley proteins using electrospinning, optimized the operation parameters to achieve uniform fibers, and incorporated Oliveria decumbens essential oil for antibacterial and antioxidant activities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Sena Su, Tuba Bedir, Cevriye Kalkandelen, Ahmet Ozan Basar, Hilal Turkoglu Sasmazel, Cem Bulent Ustundag, Mustafa Sengor, Oguzhan Gunduz
Summary: New composite materials based on poly(epsilon-caprolactone)/polyethylene oxide loaded with hyaluronic acid (HA) and keratin (KR) were produced using emulsion and coaxial electrospinning methods. The fibers demonstrated distinct morphological and chemical characteristics, and showed potential for wound healing applications through in vitro studies, as the HA and KR incorporated into the fiber structure increased cell viability and proliferation synergistically.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Parinaz Nezhad-Mokhtari, Fahimeh Kazeminava, Bahman Abdollahi, Pourya Gholizadeh, Abolfazl Heydari, Faranak Elmi, Mahmoud Abbaszadeh, Hossein Samadi Kafil
Summary: Recently, researchers have developed antibacterial wound dressings based on biomaterials that have shown good biocompatibility and the potential to accelerate wound healing. In this study, eco-friendly and biodegradable nanofibers were prepared by incorporating zeolite imidazolate framework nanoparticles and chamomile essential oil into a chitosan/ poly (& epsilon;-caprolactone) matrix using the electrospinning technique. The fabricated nanofibers demonstrated excellent cytocompatibility, proliferation, and antibacterial activity against common wound pathogens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Quanhong Hu, Xingyi Wan, Shaobo Wang, Tian Huang, Xinyang Zhao, Chuyu Tang, Minjia Zheng, Xueyu Wang, Linlin Li
Summary: This study successfully constructed a Janus nanofiber dressing with comprehensive functions of bacterial killing, piezoelectric stimulation to promote fibroblast migration, and unidirectional liquid delivery for wound exudate removal. The Janus dressing, fabricated through layer-by-layer electrostatic spinning technology, exhibits ultrathin, flexible, breathable, and piezoelectric characteristics. Experimental results indicate that the Janus dressing not only drains excess wound exudate and kills local bacteria, but also generates dynamic piezopotential to accelerate wound healing on mice through fibroblast proliferation and migration, collagen deposition, angiogenesis, and re-epithelialization.
SCIENCE CHINA-MATERIALS
(2023)
Review
Chemistry, Applied
Bing-De Zheng, Jing Ye, Yu-Cheng Yang, Ya -Yan Huang, Mei-Tian Xiao
Summary: Hydrogels have advantages such as injectability and self-healing, which play an important role in promoting wound healing and inhibiting bacterial growth.
CARBOHYDRATE POLYMERS
(2022)
Article
Biophysics
Zhongfei Gao, Qinbing Qi, Rongkai Li, Chengbo Li, Xianrui Xie, Guige Hou
Summary: A nanofiber/sponge bilayered composite membrane (QCP) containing quaternized silicone and quaternized chitosan was developed as a potential wound dressing, with feasible permeability, suitable mechanical properties, and the ability to enhance wound healing.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Zhang, Jiaxin Li, Xiao-Fei Zeng, Jie-Xin Wang, Yuan Le
Summary: In this study, double-layer hybrid nanofiber membranes (DHNM) were fabricated as bioactive wound dressings with good antibacterial effect. The inner layer released ZnONPs quickly to destroy bacteria, while the outer layer sustained the release of TiO2NPs to resist bacterial attack. The DHNM showed good biocompatibility and enhanced cell migration. The results demonstrated that the double-layer membranes effectively inhibited and eliminated various bacteria.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xingzi Lan, Yurong Liu, Yaqi Wang, Feng Tian, Xiaomin Miao, Han Wang, Yadong Tang
Summary: A series of coaxial nanofiber membranes combining antioxidant tea polyphenols in the core and antibacterial e-poly (L-lysine) in the shell layer were successfully fabricated by coaxial electrospinning. The prepared nanofibers exhibited fast antibacterial release and sustained antioxidant release, showing promise as potential wound dressing materials with good cytocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Xiaofang Chen, Yaqin Chen, Bofei Fu, Kunjie Li, Donghong Huang, Chaohui Zheng, Minghuan Liu, Da-Peng Yang
Summary: In this study, CuS nanoparticles were prepared using eggshell membranes as templates and a multifunctional nanofibrous membrane was synthesized. The nanofiber membrane exhibited antibacterial, hemostatic, and wound healing properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Chen Wang, Qingxia Zhang, Guige Hou, Chunhua Wang, Huanhuan Yan
Summary: A multifunctional polydopamine modified core-shell nanofiber membrane loaded with antibacterial quaternary ammonium salt grafted sulfonated chitosan (QAS-SCS) and bioactive EGF/bFGF was developed for promoting wound healing. The coaxial nanofibers exhibited excellent physicochemical properties and efficient antibacterial activity. In mouse full thickness skin defect model, the multifunctional nanofibers accelerated wound healing by suppressing inflammation response, enhancing collagen deposition, promoting angiogenesis, and regenerating hair follicles.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Fiaz Ahmad, Noreen Ashraf, Muhammad Inam Elahi, Yaqing Zhou, Yandu Lu, Da-Chuan Yin
Summary: This study reported the fabrication of functionalized bactericidal membranes with wound healing activity using biogenic-silver nanoparticles (b-AgNPs) by near field electrospinning. The method of membrane functionalization with b-AgNPs and the addition of polyethylene glycol (PEG) significantly affected the bactericidal and wound healing activity of the membranes. The b-AgNPs functionalized membranes showed bactericidal effects and wound healing activity, making them potential candidates for antibacterial and wound dressing materials.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Shixin Xu, Chen Du, Miaomiao Zhang, Ruoying Wang, Wei Feng, Chengwei Wang, Qinsong Liu, Wen Zhao
Summary: In this study, a series of nanofibrous membranes (NFMs) were fabricated by combining poly(e-caprolactone) (PCL), gelatin, and Ti3C2Tx MXene, as electroactive and antibacterial dressings for wound healing. The obtained NFMs showed suitable mechanical properties, excellent electroactivity, antibacterial activity, and biocompatibility. The Ti3C2Tx MXene/PCL/gelatin-6 (MPG-6) membrane exhibited the optimal conductivity and antibacterial activity. In vivo evaluation in a full-thickness wounds defect model demonstrated that the MPG-6 membrane significantly accelerated wound closure, increased tissue formation, collagen deposition, and wound vascularization. Therefore, this versatile scaffold has great potential as an ideal wound dressing for improving wound regeneration outcomes.
Article
Chemistry, Multidisciplinary
Kaleemullah Kalwar, Juqun Xi, Chuanli Ren, Ming Shen
Summary: Electrospun cellulose acetate nanofibers were synthesized and decorated with Au@AgNPs to construct effective wound dressing material. The Au@AgNPs/cellulose exhibited excellent antimicrobial activity and showed promising results in wound healing experiment.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Shan He, Huangding Wen, Nannan Yao, Lu Wang, Junqun Huang, Zhiqing Li
Summary: The composite nano-sustained release system, TTO-NL@PCS, has potential for accelerating the healing of diabetic and MRSA-infected wounds. It disperses biofilms and kills MRSA through the stable and slow release of tea tree oil. Additionally, it improves inflammatory response and wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Behnam Tahmasebi, Aida Iraji, Maedeh Sherafati, Ali Moazzam, Seyed Alireza Akhlagh, Mehdi Adib, Mohammad Mahdavi
Summary: A series of ciprofloxacin-derived Ugi adducts were designed and synthesized, and their antimicrobial activities were evaluated. The study revealed that different substituents have varied effects on the antimicrobial activities against Gram-negative and Gram-positive bacteria. The most potent derivative against Gram-negative bacteria showed lower activity against Gram-positive microorganisms. Molecular docking and molecular dynamic simulations were performed, showing the binding of one derivative to the ATP-binding sites of DNA gyrase B.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Neurosciences
Najmeh Oliyaei, Marzieh Moosavi-Nasab, Nader Tanideh, Aida Iraji
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with complex pathology. Natural products such as fucoxanthin and astaxanthin found in algae have shown promising potential in preventing and slowing down the progression of AD. These carotenoids exhibit neuroprotective properties through antioxidant and anti-inflammatory effects, as well as modulation of various targets involved in AD.
BRAIN RESEARCH BULLETIN
(2023)
Article
Multidisciplinary Sciences
Navid Dastyafteh, Milad Noori, Mohammad Nazari Montazer, Kamiar Zomorodian, Somayeh Yazdanpanah, Aida Iraji, Minoo Khalili Ghomi, Shahrzad Javanshir, Mehdi Asadi, Mehdi Dianatpour, Mahmood Biglar, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi
Summary: In this study, a series of thioxothiazolidinyl-acetamides were designed and synthesized as potential urease inhibitors. Spectroscopic techniques were used to characterize the prepared compounds, and they were found to show significant urease inhibition. Compound 6i exhibited the highest activity. Furthermore, kinetic and in silico studies were conducted on 6i, suggesting its potential as a urease inhibitor.
SCIENTIFIC REPORTS
(2023)
Article
Integrative & Complementary Medicine
Maryam Azimi, Mohammad Javad Zahedi, Mahboobeh Raeiszadeh, Aida Iraji, Holger Cramer, Mehdi Pasalar
Summary: This clinical trial compared the effects of Celery and Ajwain with Domperidone for the treatment of postprandial distress syndrome. The results showed that patients who received Celery and Ajwain had lower symptom severity and higher quality of life. Therefore, this herbal mixture can be considered as a safe and effective remedy.
COMPLEMENTARY MEDICINE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Keyvan Pedrood, Fahimeh Taayoshi, Ali Moazzam, Aida Iraji, Ali Yavari, Samira Ansari, Sayed Mahmoud Sajjadi-Jazi, Mohammad Reza Mohajeri-Tehrani, Nadia Garmsiri, Vahid Haghpanah, Meysam Soleymanibadi, Bagher Larijani, Haleh Hamedifar, Neda Adibpour, Mohammad Mahdavi
Summary: A novel series of quinazoline-based compounds with triazole-acetamides were designed and synthesized. In vitro cytotoxicity testing demonstrated that the quinazoline-oxymethyltriazole compounds exhibited moderate to good anticancer potential. The most potent derivative, 8a, showed significant activity against HCT-116 and HepG2 cancer cell lines, while 8f exhibited the best activity against MCF-7 cells. Docking studies were also conducted to investigate the interaction between these derivatives and potential targets.
Article
Biochemistry & Molecular Biology
Najmeh Oliyaei, Nader Tanideh, Marzieh Moosavi-Nasab, Amir Reza Dehghanian, Aida Iraji
Summary: The anti-obesity activity of encapsulated fucoxanthin in fucoidan-based nanoemulsion was investigated. It was found that encapsulated fucoxanthin significantly reduced body and liver weight and improved biochemical parameters and liver enzyme activity in obese rats induced by a high-fat diet.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Marjan Mollazadeh, Homa Azizian, Azadeh Fakhrioliaei, Aida Iraji, Laya Avizheh, Yousef Valizadeh, Kamiar Zomorodian, Fateme Elahi, Ali Moazzam, Houman Kazemzadeh, Massoud Amanlou, Farnia Garmciri, Elham Hamidian, Mahmood Biglar, Bagher Larijani, Mohammad Mahdavi
Summary: A new series of barbiturates linked to aryl hydrazone derivatives 4a-n were designed and synthesized. The compounds showed stronger urease inhibitory activity than standard inhibitors hydroxyurea and thiourea. Molecular dynamic studies revealed that compound 4g exhibited significant interaction with the urease active site and mobile flap residues, leading to interference with catalytic activity and reduced flexibility of the active site flap.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mina Saeedi, Roshanak Hariri, Aida Iraji, Ali Ahmadi, Somayeh Mojtabavi, Shiva Golshani, Mohammad Ali Faramarzi, Tahmineh Akbarzadeh
Summary: In this study, various N'-substituted benzylidene benzohydrazide-1,2,3-triazoles were designed, synthesized, and evaluated for their inhibitory activity against alpha-glucosidase. The structures of the derivatives were confirmed using multiple spectroscopic techniques. All derivatives exhibited potent inhibition, with IC50 values ranging from 0.01 to 648.90 μM, compared to acarbose as the positive control (IC50 = 752.10 μM). Compounds 7a and 7h showed significant potency, with IC50 values of 0.02 and 0.01 μM, respectively. Further studies revealed that these compounds are noncompetitive inhibitors of alpha-glucosidase. Fluorescence quenching and molecular docking were also used to investigate the interaction and binding mechanisms between the inhibitors and the target enzyme.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sara Moghadam Farid, Milad Noori, Mohammad Nazari Montazer, Minoo Khalili Ghomi, Marjan Mollazadeh, Navid Dastyafteh, Cambyz Irajie, Kamiar Zomorodian, Seyedeh Sara Mirfazli, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Aida Iraji, Mohammad Mahdavi
Summary: Different s-substituted benzimidazole-thioquinoline derivatives were synthesized and evaluated for their potential alpha-glucosidase inhibitory activities. The most active compound, 6j (X = 4-bromobenzyl), exhibited significant potency with an IC50 value of 28.0 +/- 0.6 μM, compared to the positive control acarbose with an IC50 value of 750.0 μM. Molecular dynamics simulations and in silico pharmacodynamics and ADMET properties were performed to assess the interactions and druggability of the derivatives. Overall, these derivatives show promise as potential alpha-glucosidase inhibitors.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Alireza Soltanfar, Abdolhamid Meimandi Parizi, Mohammad Foad-Noorbakhsh, Mansour Sayyari, Aida Iraji
Summary: This study aimed to investigate the healing effect of thymoquinone injections in a rabbit tendon injury model. The results showed that the injection of 10% concentration of thymoquinone improved mechanical performance and collagen synthesis, making it a simple and low-cost treatment for traumatic tendon injuries in rabbits.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Arshia Hashemi, Milad Noori, Navid Dastyafteh, Seyed Esmaeil Sadat-Ebrahimi, Negin Fazelzadeh Haghighi, Katayoun Mehrpour, Elahe Sattarinezhad, Fatemeh Jalali Zafrei, Cambyz Irajie, Mohammad Ali Daneshmehr, Majid Heydari, Bagher Larijani, Aida Iraji, Mohammad Mahdavi
Summary: In this study, new series of isopropylquinazolinone derivatives were designed and synthesized to discover new anti-browning and whitening agents. Compound 9q, with 4-fluorobenzyl moieties at the R position, exhibited the most potent inhibitory activity against tyrosinase with an IC50 value of 34.67 +/- 3.68 mu M. Kinetic evaluations revealed that compound 9q had mix-type inhibition. Additionally, compounds 9o and 9q demonstrated strong antioxidant capacity, confirming their potential as antioxidants. Molecular docking studies of compound 9q showed that its quinazolinone and acetamide moieties interacted with critical His residues in the binding site. These results suggest that 9q could be a suitable pharmacophore for developing potent tyrosinase inhibitors.
Article
Chemistry, Multidisciplinary
Zahra Najafi, Farshideh Rafiei, Abolfazl Ghafouri-Khosrowshahi, Mohammad Mahdavi, Mehdi Dianatpour, Aida Iraji
Summary: A series of chalcone-based 2-arylidene-1,3-indandione was synthesized and evaluated for their inhibitory activities against the mushroom tyrosinase enzyme. Among them, compound 6 l exhibited superior activity as an uncompetitive inhibitor with an IC50 value of 15.85±3.64μM, which was lower than the standard kojic acid. Docking study showed compound 6 l formed hydrogen bonds and hydrophobic interactions with critical highly conserved amino acids, and molecular dynamics simulation confirmed the stability of the ligand-enzyme complex.
Article
Multidisciplinary Sciences
Nahal Shayegan, Sirous Haghipour, Nader Tanideh, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Cambyz Irajie, Sara Parizad, Shirin Ansari, Bagher Larijani, Samanehsadat Hosseini, Aida Iraji, Mohammad Mahdavi
Summary: In this study, new structural variants of 4-hydroxyquinolinone-hydrazones were designed and synthesized. The structure elucidation of the synthetic derivatives 6a-o was determined using various spectroscopic techniques, and their alpha-glucosidase inhibitory activity was evaluated. The synthetic molecules exhibited good alpha-glucosidase inhibition with IC50 values ranging from 93.5 +/- 0.6 to 575.6 +/- 0.4 μM, compared to the standard acarbose (IC50 = 752.0 +/- 2.0 μM). Structure-activity relationships and the mode of inhibition were established through kinetic studies and molecular docking simulations.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sara Moghadam Farid, Aida Iraji, Somayeh Mojtabavi, Mehrnaz Ghasemi, Mohammad Ali Faramarzi, Mohammad Mahdavi, Maliheh Barazandeh Tehrani, Tahmineh Akbarzadeh, Mina Saeedi
Summary: New hybrids of quinazolinone-1,2,3-triazole-acetamide were synthesized and found to have significant inhibitory activity against alpha-glucosidase. The most potent compound 9c showed competitive inhibition with a K-i value of 4.8 mu M. Molecular docking and molecular dynamic simulations suggested that these compounds have the potential to be used as antidiabetic agents.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hormoz Pourtaher, Yasaman Mohammadi, Alireza Hasaninejad, Aida Iraji
Summary: This study developed a one-pot strategy for synthesizing spiroindolinone-pyrazole derivatives as potential anti-Alzheimer's disease agents. The developed synthetic procedure showed advantages in terms of reaction profile, starting materials, and purification efficiency. The synthesized derivatives were further investigated for their biological potency and molecular interactions with Alzheimer's disease-related targets.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
