Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 592, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.120081
Keywords
Skin-specific; Stimulus responsive; Drug delivery; Nanocarrier; Hydrogel; Polymer
Categories
Funding
- National Natural Science Foundation of China [81703435]
- Liaoning Province Doctoral Startup Fund of Natural Science Foundation [20170520412]
Ask authors/readers for more resources
This review discusses the development of skin-specific drug delivery systems and the impact of important stimuli on pharmaceutical formulation design, as well as introducing the characteristics of nanoscale drug carriers and the advantages of dual stimuli responsive drug delivery systems.
The concept of skin-specific drug delivery with a spatio-temporal control has just recently received concerns in dermatology. Inspired by the progress in smart materials and their perspective application in medicine science, development of stimuli responsive drug delivery systems with skin-specificity has become possible, which has led to a new era in the localized treatment of skin diseases. This review highlights both the internal and external stimuli that have been employed in this field, with a focus on their implication on the rational design of pharmaceutical formulations, especially those nanoscale drug carriers that are able to provide release of payloads with a precise spatio-temporal control in response to specific stimuli. Also, the strategy of dual stimuli responsive drug delivery systems will be discussed for further improvement of the efficacy of skin drug delivery. The prominent examples of the established approaches are described as comprehensive and current as possible. The review is expected to provide some inspiration for utilizing different stimuli for realizing the site-specific and on-demand drug delivery to the skin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available