Article
Biophysics
Hong Yu Yang, Moon-Sun Jang, Xin Shun Sun, Chang Ling Liu, Jung Hee Lee, Yi Li, Yan Fu
Summary: In this study, hypoxia-activated hyaluronic acid nanogels (HANGs) were developed for targeted delivery of photosensitizers for cancer diagnosis and photodynamic therapy. The HANGs showed rapid disassociation and high fluorescence recovery of conjugated photosensitizers under hypoxic conditions. Due to the presence of hyaluronic acid, the HANGs exhibited enhanced uptake by CD44-positive cancer cells and higher levels of reactive oxygen species generation. This tumor-targeting and singlet oxygen-producing ability of the HANGs resulted in significant inhibition of tumor growth in CD44-positive cancers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Ying Li, Chunjiao Wu, Yuewen Zhai, Ran Han, Ruoyu Gu, Yuying Ma, Peng Gao, Zhiyu Qian, Yueqing Gu, Siwen Li
Summary: A dual cascade oxygenation strategy was developed to enhance PDT treatment and alleviate post-PDT hypoxia. This strategy not only improved tumor oxygenation but also unleashed the suppression onto the tumor immune microenvironment, leading to potential clinical applications.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Renbin Zhou, Tymish Y. Ohulchanskyy, Hao Xu, Roman Ziniuk, Junle Qu
Summary: Using CatCry as an oxygen-generating system can effectively alleviate tumor hypoxia and enhance PDT efficiency. The CatCry-MB drug platform significantly enhances PDT efficiency through three mechanisms, including continuous oxygen supply, shortening of diffusion distance between O-2 and MB, and avoidance of MB aggregation.
Review
Chemistry, Multidisciplinary
Yilin Wan, Lian-Hua Fu, Chunying Li, Jing Lin, Peng Huang
Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Youjung Sim, Junmo Seong, Seonghwan Lee, Dohyun Kim, Eunshil Choi, Myoung Soo Lah, Ja-Hyoung Ryu
Summary: The integration of catalase (CAT) into metal-organic framework (MOF) nanoparticles (NPs) through supramolecular interactions enhances its cellular entry and improves the effectiveness of photodynamic therapy (PDT). This study demonstrates the potential of the protein-MOF integration strategy in overcoming tumor hypoxia and efficiently delivering biomolecular cargos.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Lin He, Feijie Xu, Yongxin Li, Honglin Jin, Pui-Chi Lo
Summary: Mixing a GSH-responsive carboxy zinc(II) phthalocyanine (ZnPc) and CuSO4 in water formed self-assembled nanotherapeutics labeled as ZnPc/Cu/SN38@NP and ZnPc/Cu@NP, which exhibited high stability in aqueous media. The nanoparticles disassembled in an acidic or GSH-enriched environment and inside HT29 cells, releasing the therapeutic components. The activated nanophotosensitizers and restored photoactivities led to substantial apoptotic cell death, and the dual therapeutic actions effectively inhibited tumor growth without notable adverse effects on mice.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Qing Chen, Su He, Fangjun Zhang, Fengzhi Cui, Jianhua Liu, Man Wang, Dongmei Wang, Zhigang Jin, Chunxia Li
Summary: The study synthesized a composite nanosystem Pt-Ce6 using porous Pt nanoparticles, which can continuously decompose H(2)O(2) into oxygen, alleviating tumor hypoxia and enhancing the effect of PDT. Additionally, Pt-Ce6 demonstrated good photothermal stability and high photothermal conversion efficiency in the NIR-II region, effectively suppressing tumor growth and recurrence under laser irradiation in U14 tumor-bearing mice.
SCIENCE CHINA-MATERIALS
(2021)
Review
Chemistry, Medicinal
Mengqi Yi, Bei Xiong, Yuyang Li, Wei Guo, Yunhan Huang, Bo Lu
Summary: Photodynamic therapy (PDT) has gained significant interest due to its low adverse effects, minimal invasiveness, and high patient compliance. However, tumor hypoxia significantly hampers the therapeutic effect of PDT, leading to tumor cell proliferation, invasion, and metastasis. Recent investigations have focused on using nanomaterials to overcome tumor hypoxia and enhance PDT efficacy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qiang Yang, Luen Xu, Jingjing Wang, Xinghong Cai, Shi-Yu Lu, Qiuye Zhang, Yifan Duan, Min Wang, Hui Liu
Summary: Integration of Fenton-induced chemodynamic therapy (CDT) and near-infrared (NIR) laser-mediated photothermal therapy (PTT)/photodynamic therapy (PDT) into a nanocomposite enables effective tumor cell killing. The nanocomposite composed of an iron (Fe) ions-decorated polypyrrole (PPy) core, IR820 payload, and bovine serum albumin (BSA) coating demonstrates superior PTT/PDT/CDT synergistic effect, achieving significant tumor cell killing under laser irradiation. The up-regulation of calreticulin expression activates immunogenic cell death, promising complete tumor elimination.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Xiaotong Li, Lei Chen, Miaoting Huang, Shaoting Zeng, Jiayi Zheng, Shuyi Peng, Yuqing Wang, Hong Cheng, Shiying Li
Summary: Photodynamic therapy (PDT) is a powerful therapeutic option for tumors, but the hypoxic tumor microenvironment limits the supply of oxygen and affects the effectiveness of PDT. Innovative strategies to relieve tumor hypoxia and enhance PDT efficiency have been developed, including O2-independent PDT and synergistic therapies. Future studies should focus on addressing the challenges and exploring the prospects of these strategies.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Huairong Zhang, Mei Yao, Lu Feng, Zizhen Wei, Yuqi Wang, Wenxiu Han, Shusheng Zhang
Summary: In this study, E. coli was utilized for cancer therapy by using its tumor-targeting, catalytic, and surface-reducing properties. The E-Au@Rf@Lum probe, achieved through the surface reduction of HAuCl4 and carrier modification with riboflavin (Rf) and luminol (Lum) by E. coli, has the ability to emit blue-violet chemiluminescence (CL) for cancer cell imaging. This work opens up a self-amplified therapy modality to tumor through self-illumination, effective penetration, and tumor hypoxia relief.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Liang Hong, Jianman Wang, Yi Zhou, Guofu Shang, Tao Guo, Hailong Tang, Jiangmin Li, Yali Luo, Xiangyu Zeng, Zhu Zeng, Zuquan Hu
Summary: Tumor hypoxia can reduce the effectiveness of photodynamic therapy (PDT). Two approaches, in situ oxygen generation and oxygen delivery, have been developed to address this issue. In situ oxygen generation involves using catalysts to decompose excess H2O2 produced by tumors, while oxygen delivery uses substances with high oxygen solubility to transport oxygen. To combine the benefits of both approaches, we developed a nanoemulsion system called CCIPN. CCIPN can store oxygen generated by catalysts for use in PDT, and it shows promise as an oxygen-supplementing PDT nanomaterial.
Review
Biochemistry & Molecular Biology
Liang Hong, Jiangmin Li, Yali Luo, Tao Guo, Chenshuang Zhang, Sha Ou, Yaohang Long, Zuquan Hu
Summary: This review summarizes the latest strategies for overcoming hypoxia in tumor photodynamic therapy (PDT), categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. The strengths, shortcomings, opportunities, and challenges of different methods are analyzed.
Article
Pharmacology & Pharmacy
Chunmei Lai, Bangyue Luo, Jiangwen Shen, Jingwei Shao
Summary: Photodynamic therapy (PDT) is a widely used non-invasive therapeutic modality for cancer treatment, but the presence of hypoxia in tumor tissue severely hinders its efficiency. In this review, the mechanisms and therapeutic efficacy of PDT for tumor cell ablation are summarized, and current advances in nanomaterials-mediated tumor oxygenation to alleviate hypoxia are emphasized.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Physical
Shanshan Song, Miao Yang, Fei He, Xiao Zhang, Yijun Gao, Baichao An, He Ding, Shili Gai, Piaoping Yang
Summary: This study presents a simple method to prepare transition metals loaded onto pyrrolic nitrogen-rich g-C3N4 for forming metal-N4 sites. The prepared nanoenzyme can effectively kill tumor cells through a photodynamic effect and a Fenton-like reaction in the tumor microenvironment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Tianyang Li, Chunsheng Yang, Zhiping Wei, Dongsheng Pei, Guan Jiang
ONCOTARGETS AND THERAPY
(2020)
Article
Biotechnology & Applied Microbiology
Xinxin Li, Chunsheng Yang, Yingkai Tao, Xiaoyang Hou, Yanqun Liu, Hong Sang, Guan Jiang
Summary: A novel targeted drug delivery system for melanoma combining chemo and photothermal therapy was developed, showing efficient photothermal conversion and drug release performance. The liposomes exhibited concentration-dependent uptake by melanoma cells, entering cells via endocytosis and storing in lysosomes. Exposure to NIR laser resulted in a significant reduction in cell viability, indicating a promising chemo/photothermal effect.
ONCOTARGETS AND THERAPY
(2021)
