Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Rikang Wang, Weili Bao, Mouli Pal, Yunfeng Liu, Karina Yazdanbakhsh, Hui Zhong
Summary: This study identified the antimetastasis and pro-NK cell activity of IFN-IMo, identified FOXO1 as a key molecule for IFN-gamma driven monocyte differentiation and function, and found NR4A1 as an inhibitory molecule for IFN-IMo activity. It provided potential targets for developing superior monocytic cell therapy against cancer metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Peng Peng, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng, Ping Liu, Lisa X. Xu
Summary: This study demonstrates that cryo-thermal therapy can induce effective CD4(+) Th1-dominant antitumor immunity by activating NK cells to reprogram MDSCs, offering a promising therapeutic strategy for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Prashanta Silwal, In Soo Kim, Eun-Kyeong Jo
Summary: Autophagy plays a crucial role in enhancing the immune responses and controlling inflammation against NTM infections, and holds potential as a therapeutic target for combating NTM infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kellen J. Cavagnero, Richard L. Gallo
Summary: Fibroblasts are stromal cells that produce extracellular matrix and play a role in tissue structure and scar formation. Recent studies have found that they are highly heterogeneous and actively participate in both innate and adaptive immune defense. Detailed analysis of barrier tissues such as skin, gut, and lung shows that some fibroblasts directly sense pathogens and other danger signals, contributing to host defense functions such as antimicrobial activity, white blood cell recruitment, and production of cytokines relevant to inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Frederique St-Pierre, Shailender Bhatia, Sunandana Chandra
Summary: Cancer immunotherapy has traditionally focused on adaptive immunity, but there is increasing recognition of the important role innate immunity plays in the body's response to neoplastic cells. Targeting natural killer (NK) cells, a key component of the innate immune response, for cancer treatment shows promise in developing innovative strategies for immunotherapy.
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wohr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B. Thoren
Summary: This study found that the NKG2A gene variant is associated with enhanced NK cell effector function and improved outcome of IL-2-based immunotherapy in AML.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Caiyun Qi, Fang Liu, Wenjun Zhang, Yali Han, Nan Zhang, Qiang Liu, Handong Li
Summary: This study identified a distinct subset of NK cells and its potential involvement in Alzheimer's disease (AD) through analyzing single-cell RNA sequencing data and flow cytometry. The unique NK cell subset was found to be associated with the progression of AD and negatively correlated with cognitive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jae-Min Yuk, Eun-Jin Park, In Soo Kim, Eun-Kyeong Jo
Summary: Itaconate is an important immunometabolite with anti-infective and anti-inflammatory properties. Its derivatives and isomers have potential as drugs for inflammation and infection. However, the exact mechanisms of action and the therapeutic potential of Itaconate are not fully understood due to contradictory results and a lack of clinical data. Further research is needed to understand how itaconate exerts its effects and to explore its therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shalu Sharma Kharkwal, Christopher T. Johndrow, Natacha Veerapen, Himanshu Kharkwal, Noemi A. Saavedra-Avila, Leandro J. Carreno, Samantha Rothberg, Jinghang Zhang, Scott J. Garforth, Peter J. Jervis, Lianjun Zhang, Alena Donda, Amareeta K. Besra, Liam R. Cox, Steven C. Almo, Alan Howell, Elizabeth E. Evans, Maurice Zauderer, Gurdyal S. Besra, Steven A. Porcelli
Summary: A novel bispecific T-cell engager (BiTE) was developed to activate iNKT cells for antitumor immunity, enhancing multiple effector functions and promoting tumor-specific CD8(+) cytolytic T-cell responses. Simultaneous checkpoint blockade with anti-CTLA-4 antibodies further enhanced the antitumor effects, providing a potential approach for combination immunotherapy. Multiple injections of covalently stabilized iNKT cell-specific BiTEs led to effective and nontoxic cancer immunotherapy regimens without inducing anergy or exhaustion in responding iNKT cells.
Article
Biochemistry & Molecular Biology
Daniel Christoph Amberger, Fatemeh Doraneh-Gard, Carina Gunsilius, Melanie Weinmann, Sabine Moebius, Christoph Kugler, Nicole Rogers, Corinna Boeck, Uwe Koedel, Jan-Ole Werner, Doris Kraemer, Britta Eiz-Vesper, Andreas Rank, Christoph Schmid, Helga Maria Schmetzer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Joerg Schmohl, Sabine Moebius, Thomas Guenther, Elena Pepeldjyika, Corinna L. Seidel, Wishnu Sutanto, Friedhelm Schuster, Doris Kraemer, Helmut Salih, Amely Hartmann, Johanna Tischer, Christian Ries, Helga Schmetzer
Summary: The study found that mature B-linear blasts in ALL expressed higher levels of 82kDa proMMP-9, while in CLL, the expression of 82kDa proMMP-9 was not correlated with clinical parameters. Higher levels of 82kDa proMMP-9 expression on blast cells may be associated with a more unfavorable ALL-subtype.
ANTICANCER RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Corinna L. Seidel, Roman G. Gerlach, Matthias Weider, Theresa Woelfel, Vincent Schwarz, Armin Strobel, Helga Schmetzer, Christian Bogdan, Lina Goelz
Summary: Orthodontic treatment with fixed appliances can lead to oral problems, and probiotics may help improve clinical parameters and reduce inflammation, but their effects in orthodontics are not well understood.
Article
Anatomy & Morphology
Ines Willershausen, Franziska Krautkremer, Tobias Hilbert, Corinna Lesley Seidel, Carol-Immanuel Geppert, Shahram Ghanaati, Fabian Necker, Friedrich Paulsen, Lina Golz, Michael Scholz
Summary: The study evaluated the edentulous mid-palatal sutures compared to dentulous controls and found significant morphological differences, including decreased vascularization, sutural width, and increased sutural obliteration in edentulous individuals. There was high variability and inhomogeneity in histomorphometric parameters in the edentulous samples.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Immunology
Elena Pepeldjiyska, Lin Li, Jincheng Gao, Corinna L. Seidel, Christian Blasi, Erdem Oezkaya, Jorg Schmohl, Doris Kraemer, Christoph Schmid, Andreas Rank, Helga Maria Schmetzer
Summary: This study focused on the influence of Kit-M treated DC/DCleu in the whole blood of leukemia patients on the generation of immunosuppressive regulatory T-cells. The results showed that Kit-M significantly increased the frequency of mature dendritic cells and leukemia-derived dendritic cells, leading to enhanced leukemia-specific immune responses and cytotoxicity against leukemia cells.
Article
Biochemistry & Molecular Biology
Elias Rackl, Lin Li, Lara Kristina Klauer, Selda Ugur, Elena Pepeldjiyska, Corinna L. Seidel, Carina Gunsilius, Melanie Weinmann, Fatemeh Doraneh-Gard, Nina Reiter, Caroline Plett, Daniel Christoph Amberger, Peter Bojko, Doris Kraemer, Joerg Schmohl, Andreas Rank, Christoph Schmid, Helga Maria Schmetzer
Summary: This study analyzed whether the stimulation of immune cells by dendritic cells would lead to increased expression of Integrin beta 7 (β7) and improved antileukemic cytotoxicity. The results showed that specific treatment methods can increase the expression of β7 in immune cells and it is associated with leukemia cell lysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Corinna L. L. Seidel, Elena Percivalle, Marco Tschaftari, Matthias Weider, Karin Strobel, Ines Willershausen, Christoph Unertl, Helga M. M. Schmetzer, Manuel Weber, Michael Schneider, Benjamin Frey, Udo S. S. Gaipl, Matthias W. W. Beckmann, Lina Goelz
Summary: The study found significantly increased levels of oral cytokines in neonates with orofacial clefts, especially at the first consultation after birth. Furthermore, a significant positive correlation was detected between cleft severity and specific pro-inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Corinna L. Seidel, Karin Strobel, Matthias Weider, Marco Tschaftari, Christoph Unertl, Ines Willershausen, Manuel Weber, Andre Hoerning, Patrick Morhart, Michael Schneider, Matthias W. Beckmann, Christian Bogdan, Roman G. Gerlach, Lina Goelz
Summary: Orofacial clefts (OFC) affect the development of oral microbiota, leading to differences in alpha diversity and bacterial species compared to neonates without OFC. Neonates with OFC have lower alpha diversity and higher levels of specific bacterial species, indicating the influence of OFC phenotype and severity on oral microbiota maturation. Neonates with cleft palate only show significant differences in anaerobic species compared to those with unilateral and bilateral cleft lip and palate.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Andrea Wichelhaus, Amelie Mehnert, Thomas Stocker, Uwe Baumert, Matthias Mertmann, Hisham Sabbagh, Corinna L. Seidel
Summary: The shape of superelastic Nickel-Titanium archwires can be adjusted with thermal treatments, which have an effect on their mechanical properties. Different combinations of annealing duration and temperature determine the complete shape adaptation range and the temperature at which superelastic properties are lost. Forestadent's Titanol Superelastic, Dentaurum's Tensic, Rocky Mountain Orthodontics' FLI CuNiTi27, and 3M Unitek's Nitinol Classic are the most user-friendly wires.
Article
Dentistry, Oral Surgery & Medicine
Robert Parhofer, Andrea Rau, Karin Strobel, Lina Goelz, Renee Stark, Lucas M. Ritschl, Klaus-Dietrich Wolff, Marco R. Kesting, Florian D. Grill, Corinna L. Seidel
Summary: By comparing the pre- and post-PSIO maxillary models of infants with unilateral non-syndromic cleft lip palate treated with PAM or NAM, it was found that NAM can effectively reduce the anterior cleft and achieve greater medial rotation, while PAM allows for more transversal and sagittal growth.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Matthias Weider, Agnes Schroeder, Denitsa Docheva, Gabriele Rodrian, Isabel Enderle, Corinna Lesley Seidel, Darja Andreev, Michael Wegner, Aline Bozec, James Deschner, Christian Kirschneck, Peter Proff, Lina Goelz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Corinna L. Seidel, Roman G. Gerlach, Patrick Wiedemann, Matthias Weider, Gabriele Rodrian, Michael Hader, Benjamin Frey, Udo S. Gaipl, Aline Bozec, Fabian Cieplik, Christian Kirschneck, Christian Bogdan, Lina Goelz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Corinna L. Boeck, Daniel C. Amberger, Fatemeh Doraneh-Gard, Wishnu Sutanto, Thomas Guenther, Joerg Schmohl, Friedhelm Schuster, Helmut Salih, Florian Babor, Arndt Borkhardt, Helga Schmetzer
JOURNAL OF IMMUNOTHERAPY
(2017)
