Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

(2020) Koichi Ishida et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structural basis for the activation of acid ceramidase

(2018) Ahmad Gebai et al.   Nature Communications

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition

(2017) Mogbekeloluwa Danso et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate

(2014) Ami Oizumi et al.   PLoS One

Reevaluation of the non-lesional dry skin in atopic dermatitis by acute barrier disruption: an abnormal permeability barrier homeostasis with defective processing to generate ceramide

(2013) Ayumi Sugiura et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

(2011) Michelle Janssens et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

(2010) J. M. Jungersted et al.   ALLERGY

Changes in the Ceramide Profile of Atopic Dermatitis Patients

(2010) Junko Ishikawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

(2009) Genji Imokawa   JOURNAL OF DERMATOLOGICAL SCIENCE

Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

(2008) Nataly Shtraizent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY