Review
Immunology
Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: It is increasingly believed that diabetes in cats may belong to both metabolic and autoimmune diseases due to the involvement of the immune system and secretion of adipokines. Risk factors include age, sex, breed, obesity, and insulin resistance. Diagnosis of diabetes in cats is more complicated than in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Article
Multidisciplinary Sciences
Nigusie Gashaye Shita, Essey Kebede Muluneh
Summary: Vascular complications in Type 2 diabetes mellitus patients can lead to serious physical damage and even death. Factors such as positive proteinuria, high serum creatinine levels, elevated cholesterol, and fasting blood glucose levels were found to be significant predictors of shorter time to developing vascular complications. Factors like treatment duration, hypertension, baseline fasting blood glucose levels, gender, number of hospital visits, and medication requirements also played a role in the progression of blood sugar levels and risk of developing complications.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sanjeela R. Guru, Suchetha Aghanashini
Summary: This study compared and correlated salivary and serum levels of PAI-1 and α2MG in patients with periodontitis with and without T2DM, and assessed the impact of periodontal treatment on these biomarkers. The results showed that levels of salivary and serum PAI-1 and α2MG were higher in patients with periodontitis and diabetes compared to periodontitis alone, and these biomarkers decreased after periodontal treatment. The study suggests that salivary PAI-1 could be a diagnostic biomarker and can track the response to periodontal therapy.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Ying-Chen Chen, Bing-Ze Lu, Yu-Chen Shu, Yuan-Ting Sun
Summary: This study found that cerebral microangiopathy with increased blood-brain barrier leakage occurs early in patients with type 2 diabetes mellitus (T2DM), before the appearance of cerebral small vessel disease (CSVD) on MRI. The involvement of white matter and gray matter is different in T2DM-related CSVD, and there are distinct features and mechanisms compared to other CSVDs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Daoli Liu, Xubing Zhang, Hong Zhou, Zhiqiang Zhu, Yiren He, Xiao Wan, Bo Zhang, Shaojun Liu, Liu Liu
Summary: This study aimed to evaluate the impact of type 2 diabetes mellitus (T2DM) on the short-term outcomes and long-term survival of patients with colorectal cancer (CRC) who underwent curative resection. The results showed that patients with T2DM had more complications after surgery, longer hospitalization time, and worse prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Mingyue Xu, Ruiying Feng, Ruoqi Feng, Xiaofei Yin, Lei Zhang, Chuan Wang, Jinbo Liu
Summary: This study aimed to investigate the relationship between Ism-1 levels and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (T2DM). The results showed that serum Ism-1 levels were inversely correlated with GFR, and high levels of Ism-1 may serve as a potential biomarker for predicting kidney function impairment in patients with T2DM.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Review
Biochemistry & Molecular Biology
Raquel Sanabria-de la Torre, Cristina Garcia-Fontana, Sheila Gonzalez-Salvatierra, Francisco Andujar-Vera, Luis Martinez-Heredia, Beatriz Garcia-Fontana, Manuel Munoz-Torres
Summary: Vascular complications are the main cause of morbidity and mortality in patients with type 2 diabetes mellitus. The Wnt pathway plays an important role in the pathophysiology of the vascular wall and is altered in patients with type 2 diabetes. This review analyzes both microvascular and macrovascular complications and highlights the importance of exploring therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Khadija Hafidh, Rachid Malek, Khalid Al-Rubeaan, Adri Kok, Fahri Bayram, Akram Echtay, Viraj Rajadhyaksha, Ahmed Hadaoui
Summary: This study evaluated the prevalence of vascular complications and associated risk factors in individuals with type 2 diabetes initiating second-line glucose-lowering therapy in the Middle East and Africa region. The study found a substantial burden of vascular complications in this cohort, with age, male sex, hyperlipidemia, and hypertension being significant risk factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Dyah Purnamasari, Cindya Klarisa Simanjuntak, Christian Tricaesario, Dicky Levenus Tahapary, Dante Saksono Harbuwono, Em Yunir
Summary: This study aimed to compare the adipokine profiles between first-degree relatives (FDR) of type 2 diabetes and non-FDR. The results showed that non-obese FDR had a higher L/A ratio, and the FDR status was significantly associated with adiponectin level. This suggests that FDR status may contribute to the development of adipokine dysregulation before obesity occurs.
Article
Endocrinology & Metabolism
Mark A. Espeland, Joni K. Evans, Owen Carmichael, Jose A. Luchsinger, Santica M. Marcovina, Rebecca Neiberg, Karen C. Johnson, Steven E. Kahn, Kathleen M. Hayden
Summary: This study analyzed the data from the Look AHEAD study and found that participants who underwent a 10-year intensive lifestyle intervention had relative deficits in cognitive function. However, the changes in two weight-sensitive proangiogenic cytokines, leptin and VEGF, did not account for these adverse effects on cognitive function.
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Petros Katsogiannos, Prasad G. Kamble, Maria J. Pereira, Magnus Sundbom, Per-Ola Carlsson, Jan W. Eriksson, Daniel Espes
Summary: The study compared cytokine and adipokine levels in obese patients before and after RYGB surgery, finding that despite improvements in metabolic status and weight loss, the altered cytokine profile persisted, indicating an inherent inflammatory state in obese patients.
Article
Microbiology
Da Som Jeon, Seonok Kim, Mi Ae Kim, Yong Pil Chong, Tae Sun Shim, Chang Hee Jung, Ye-Jee Kim, Kyung-Wook Jo
Summary: This study aimed to investigate the association between type 2 diabetes mellitus (T2DM) and nontuberculous mycobacterial (NTM) disease. The results showed that T2DM alone did not significantly increase the risk of NTM disease, but T2DM with >= 2 diabetes-related complications significantly increased the risk of NTM disease.
MICROBIOLOGY SPECTRUM
(2023)
Article
Endocrinology & Metabolism
Xiaojing Shang, Rui Zhang, Xiaolai Wang, Junxin Yao, Xiaoying Zhao, Huanming Li
Summary: Elevated serum ferritin is closely related to metabolism and chronic complications in type 2 diabetes, especially in men.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)