Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Bo Han Chen, Xiao Qing Lu, Xian Hui Liang, Pei Wang
Summary: Diabetic kidney disease induces tubular degeneration and premature cellular senescence, partially mediated by Serpin E1 signaling.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Max Liu, Khalequz Zaman, Yolanda M. Fortenberry
Summary: Aptamers are single-stranded DNA or RNA sequences that exhibit high specificity and affinity in binding target molecules. They are non-immunogenic, easier to synthesize and modify, and can bind targets with greater affinity, making them a promising therapeutic candidate for treating various conditions. Active research is ongoing in developing aptamers to target blood coagulation factors, with potential applications in treating cardiovascular diseases, blood disorders, and cancers. Although no aptamers targeting blood coagulation factors have been approved for clinical use, several have shown promise in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Hua Xu, Qi Wang, Qian Wang, Xuan Qiang Che, Xue Liu, Shumiao Zhao, Shitao Wang
Summary: The study showed that serum apelin levels were higher in diabetic patients compared to healthy controls, and even higher in patients with DPN compared to those without DPN. After treatment, apelin levels decreased and were significantly lower in the DPN-B group, while some nerve conduction velocity values increased in this group. Apelin was negatively correlated with some nerve conduction velocity values and positively correlated with TNF-alpha and fasting blood glucose.
Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Julie Brogaard Larsen, Anne-Mette Hvas
Summary: This review highlights the key changes in fibrinolysis during sepsis, points out the current lack of reliable biomarkers for assessing fibrinolysis in clinical settings, and discusses the potential value of drugs targeting the fibrinolytic system in sepsis patients.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Immunology
Alaa Efat, Sabry Abdallah Shoeib, Ayman F. Arafa, Ashraf Abdelraof Dawod, Mohamad A. Abd ElHafez, Essam A. Abd ElMohsen, Hany F. Eladly, Reda A. Ibrahim, Aly Elkholy
Summary: SuPAR and PAI-1 were found to be significant predictors of hospital mortality among sepsis patients, and could serve as predictive markers for early death. However, the relatively small sample size may have decreased the statistical power of the study, warranting further research with larger sample sizes to validate these findings.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yan Bi, Dalong Zhu, Jinluo Cheng, Yan Zhu, Ning Xu, Shiwei Cui, Wei Li, Xingbo Cheng, Fei Wang, Yun Hu, Shanmei Shen, Jianping Weng
CLINICAL THERAPEUTICS
(2010)
Article
Endocrinology & Metabolism
Xingbo Cheng, Hui Zhang
DIABETES RESEARCH AND CLINICAL PRACTICE
(2009)
Article
Endocrinology & Metabolism
Xingbo Cheng, Bei Zhu, Fusong Jiang, Huaying Fan
ENDOCRINE RESEARCH
(2011)
Article
Endocrinology & Metabolism
Lei Zhang, Yuming Fu, Nan Zhou, Xingbo Cheng, Chao Chen
Article
Endocrinology & Metabolism
Zimiao Chen, Hongwei Sun, Jian Wang, Liansong Ni, Xuejiang Gu, Shengjie Ge, Qiong Chen, Liangshan Mu, Xingbo Cheng
Article
Endocrinology & Metabolism
Changjiang Ying, Xiaoyan Zhou, Zhenzhen Chang, Hongwei Ling, Xingbo Cheng, Wei Li