T6SS Mediated Stress Responses for Bacterial Environmental Survival and Host Adaptation

Biofilm Bacteria Use Stress Responses to Detect and Respond to Competitors

(2020) Bram Lories et al.   CURRENT BIOLOGY

Envelope stress responses defend against type six secretion system attacks independently of immunity proteins

(2020) Steven J. Hersch et al.   Nature Microbiology

HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in Yersinia pseudotuberculosis

(2020) Zhuo Wang et al.   Frontiers in Microbiology

Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System

(2020) Fatima Kamal et al.   Cell Reports

Salmonella enteritidis Hcp distribute in the cytoplasm and regulate TNF signaling pathway in BHK-21 cells

(2020) Liming Zheng et al.   3 Biotech

EvpP inhibits neutrophils recruitment via Jnk-caspy inflammasome signaling in vivo

(2019) Jinchao Tan et al.   FISH & SHELLFISH IMMUNOLOGY

A novel contact-independent T6SS that maintains redox homeostasis via Zn2+ and Mn2+ acquisition is conserved in the Burkholderia pseudomallei complex

(2019) David DeShazer   MICROBIOLOGICAL RESEARCH

Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments

(2018) Yang Fu et al.   Cell Host & Microbe

The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

(2018) Melvin G. Renault et al.   JOURNAL OF MOLECULAR BIOLOGY

Exopolysaccharide protectsVibrio choleraefrom exogenous attacks by the type 6 secretion system

(2018) Jonida Toska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Determinants of Penicillin Tolerance in Vibrio cholerae

(2018) Anna I. Weaver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Where in the world do bacteria experience oxidative stress?

(2018) James A. Imlay   ENVIRONMENTAL MICROBIOLOGY

The Two-Component Signal Transduction System VxrAB Positively Regulates Vibrio cholerae Biofilm Formation

(2017) Jennifer K. Teschler et al.   JOURNAL OF BACTERIOLOGY

ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis

(2017) Tietao Wang et al.   JOURNAL OF MICROBIOLOGY

Microbial antioxidant defense enzymes

(2017) Cindy Staerck et al.   MICROBIAL PATHOGENESIS

Escherichia colicytochromecperoxidase is a respiratory oxidase that enables the use of hydrogen peroxide as a terminal electron acceptor

(2017) Maryam Khademian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese scavenging and oxidative stress response mediated by type VI secretion system inBurkholderia thailandensis

(2017) Meiru Si et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies

(2017) Martina Lazzaro et al.   mBio

The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition

(2017) Meiru Si et al.   Cell Reports

Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)

(2017) Baoshan Wan et al.   PLoS Pathogens

Response of Vibrio cholerae to Low-Temperature Shifts: CspV Regulation of Type VI Secretion, Biofilm Formation, and Association with Zooplankton

(2016) Loni Townsley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration

(2016) Vladimir E. Diaz-Ochoa et al.   Cell Host & Microbe

Identification of protein secretion systems in bacterial genomes

(2016) Sophie S. Abby et al.   Scientific Reports

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance

(2015) Meiru Si et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

SecReT6: a web-based resource for type VI secretion systems found in bacteria

(2015) Jun Li et al.   ENVIRONMENTAL MICROBIOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Duox1-Derived H2O2Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications

(2015) Sofia de Oliveira et al.   JOURNAL OF IMMUNOLOGY

Generation of reactive oxygen species by lethal attacks from competing microbes

(2015) Tao G. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance

(2015) Tobias Dörr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655

(2015) Sang Woo Seo et al.   Cell Reports

Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity

(2015) Tietao Wang et al.   PLoS Pathogens

In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

RNA thermometer controls temperature-dependent virulence factor expression inVibrio cholerae

(2014) Gregor G. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition

(2014) Daniel Unterweger et al.   Nature Communications

Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress

(2014) Des Raj Kashyap et al.   PLoS Pathogens

Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions

(2013) Marek Basler et al.   CELL

Tn-Seq Analysis of Vibrio cholerae Intestinal Colonization Reveals a Role for T6SS-Mediated Antibacterial Activity in the Host

(2013) Yang Fu et al.   Cell Host & Microbe

MarR family transcription factors

(2013) Anne Grove   CURRENT BIOLOGY

Antimicrobial functions of inflammasomes

(2013) Kaiwen W Chen et al.   CURRENT OPINION IN MICROBIOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Manganese acquisition and homeostasis at the host-pathogen interface

(2013) John P. Lisher et al.   Frontiers in Cellular and Infection Microbiology

Regulators of oxidative stress response genes in Escherichia coli and their functional conservation in bacteria

(2012) Sarah M. Chiang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion inPseudomonas aeruginosa

(2012) Maria G. Casabona et al.   ENVIRONMENTAL MICROBIOLOGY

A type VI secretion system regulated by OmpR inYersinia pseudotuberculosisfunctions to maintain intracellular pH homeostasis

(2012) Weipeng Zhang et al.   ENVIRONMENTAL MICROBIOLOGY

Zinc and the modulation of redox homeostasis

(2012) Patricia I. Oteiza   FREE RADICAL BIOLOGY AND MEDICINE

Battles with Iron: Manganese in Oxidative Stress Protection

(2012) J. Dafhne Aguirre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster ofSerratia marcescens

(2012) Grant English et al.   MOLECULAR MICROBIOLOGY

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds

(2012) K. Barnese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 6 Secretion Dynamics Within and Between Bacterial Cells

(2012) M. Basler et al.   SCIENCE

Acid-Induced Type VI Secretion System Is Regulated by ExoR-ChvG/ChvI Signaling Cascade in Agrobacterium tumefaciens

(2012) Chih-Feng Wu et al.   PLoS Pathogens

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

(2011) S. L. Murdoch et al.   JOURNAL OF BACTERIOLOGY

Molecular Basis for the Unique Role of the AAA+Chaperone ClpV in Type VI Protein Secretion

(2011) Aleksandra Pietrosiuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression analysis of monospecies Salmonella Typhimurium biofilms using Differential Fluorescence Induction

(2011) Kim Hermans et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei

(2011) M. Vanaporn et al.   MICROBIOLOGY-SGM

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

Bacterial outer membrane channel for divalent metal ion acquisition

(2011) T. H. Hohle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium

(2010) Tsukasa Horiyama et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1

(2010) O. L. Champion et al.   MICROBIOLOGY-SGM

Tubules and donuts: a type VI secretion story

(2010) Gabriele Bönemann et al.   MOLECULAR MICROBIOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Control of bacterial iron homeostasis by manganese

(2010) S. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

(2009) Frédéric Boyer et al.   BMC GENOMICS

Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion

(2009) Gabriele Bönemann et al.   EMBO JOURNAL

Type VI secretion modulates quorum sensing and stress response inVibrio anguillarum

(2009) Barbara Weber et al.   ENVIRONMENTAL MICROBIOLOGY

TagR promotes PpkA-catalysed type VI secretion activation inPseudomonas aeruginosa

(2009) FoSheng Hsu et al.   MOLECULAR MICROBIOLOGY

MzrA: a novel modulator of the EnvZ/OmpR two-component regulon

(2009) Henri Gerken et al.   MOLECULAR MICROBIOLOGY

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin

(2009) P. G. Leiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rcs Phosphorelay Is a Cell Envelope Stress Response Activated by Peptidoglycan Stress and Contributes to Intrinsic Antibiotic Resistance

(2008) M. E. Laubacher et al.   JOURNAL OF BACTERIOLOGY

The bacterial type VI secretion machine: yet another player for protein transport across membranes

(2008) A. Filloux et al.   MICROBIOLOGY-SGM

Transcriptional activation by MarA, SoxS and Rob of twotolCpromoters using one binding site: a complex promoter configuration fortolCinEscherichia coli

(2008) Aixia Zhang et al.   MOLECULAR MICROBIOLOGY

Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: New insights into two-component system regulon plasticity in bacteria

(2007) Claire Flamez et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY