Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/ijms21249500
Keywords
Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; gene expression; long non-coding RNAs
Funding
- Fondazione Regionale Ricerca Biomedica (TRANS-ALS) [2015-0023]
- Italian Ministry of Health (Ricerca Corrente 2018-2020)
- Italian Ministry of Health [GR-2016-02361552]
- EuroNanoMed III JTC 2018
- Italian Ministry of Health
- Cariplo Foundation (Italy) [FrailBioTrack 2017-0557]
- Agenzia Italiana del Farmaco [2016-02364678]
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Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by a progressive degeneration of the central or peripheral nervous systems. A central role of the RNA metabolism has emerged in these diseases, concerning mRNAs processing and non-coding RNAs biogenesis. We aimed to identify possible common grounds or differences in the dysregulated pathways of AD, PD, and ALS. To do so, we performed RNA-seq analysis to investigate the deregulation of both coding and long non-coding RNAs (lncRNAs) in ALS, AD, and PD patients and controls (CTRL) in peripheral blood mononuclear cells (PBMCs). A total of 293 differentially expressed (DE) lncRNAs and 87 mRNAs were found in ALS patients. In AD patients a total of 23 DE genes emerged, 19 protein coding genes and four lncRNAs. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses, we found common affected pathways and biological processes in ALS and AD. In PD patients only five genes were found to be DE. Our data brought to light the importance of lncRNAs and mRNAs regulation in three principal neurodegenerative disorders, offering starting points for new investigations on deregulated pathogenic mechanisms.
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