Role of Nucleotide Excision Repair in Cisplatin Resistance

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

(2020) Zuzana Cierna et al.   BMC CANCER

A panorama of transcription-coupled repair in yeast chromatin

(2020) Dong Wang   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin

(2020) Mingrui Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells

(2019) Xue Teng et al.   ONCOLOGY REPORTS

Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCF FBXL18 E3 ligase

(2019) Masanobu Ueda et al.   GENES TO CELLS

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF

(2019) Ahmed H. Elmenoufy et al.   JOURNAL OF MEDICINAL CHEMISTRY

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer

(2018) Qiang Li et al.   CLINICAL CANCER RESEARCH

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Overexpression of xeroderma pigmentosum group�C decreases the chemotherapeutic sensitivity of colorectal carcinoma cells to cisplatin

(2018) Yi Zhang et al.   Oncology Letters

Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin

(2018) Michael G. Kemp et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage

(2018) Jana Slyskova et al.   NUCLEIC ACIDS RESEARCH

DNA repair pathways and cisplatin resistance: an intimate relationship

(2018) CR Rocha et al.   Clinics

XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells

(2018) Natalia Pajuelo-Lozano et al.   Frontiers in Pharmacology

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity

(2017) Samuel G. Awuah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XPA: A key scaffold for human nucleotide excision repair

(2016) Norie Sugitani et al.   DNA REPAIR

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice

(2016) R. N. Rainey et al.   JOURNAL OF NEUROSCIENCE

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

(2016) Jaegil Kim et al.   NATURE GENETICS

Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution

(2016) Jinchuan Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High ERCC1 expression is associated with platinum-resistance, but not survival in patients with epithelial ovarian cancer

(2016) Pei Du et al.   Oncology Letters

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

(2016) Sanjeevani Arora et al.   Oncotarget

Clinical Validation of Chemotherapy Response BiomarkerERCC2in Muscle-Invasive Urothelial Bladder Carcinoma

(2016) David Liu et al.   JAMA Oncology

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum

(2014) Sergey Alekseev et al.   CHEMISTRY & BIOLOGY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

(2014) E. M. Van Allen et al.   Cancer Discovery

In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair

(2014) Jochen Kuper et al.   PLOS BIOLOGY

ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform

(2013) Luc Friboulet et al.   CELL CYCLE

The CSB repair factor is overexpressed in cancer cells, increases apoptotic resistance, and promotes tumor growth

(2013) Manuela Caputo et al.   DNA REPAIR

The role of Cockayne syndrome group A (CSA) protein in transcription-coupled nucleotide excision repair

(2013) Masafumi Saijo   MECHANISMS OF AGEING AND DEVELOPMENT

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

(2013) Guangwu Guo et al.   NATURE GENETICS

ERCC1 Isoform Expression and DNA Repair in Non–Small-Cell Lung Cancer

(2013) Luc Friboulet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian Transcription-Coupled Excision Repair

(2013) W. Vermeulen et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

(2012) Yuka Nakazawa et al.   NATURE GENETICS

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction

(2012) Khaled H. Barakat et al.   PLoS One

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Identification of Novel Small Molecule Inhibitors of the XPA Protein Usingin SilicoBased Screening

(2010) Tracy M. Neher et al.   ACS Chemical Biology

Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin

(2010) Lawton J Stubbert et al.   BMC CANCER

Downregulation of XPF–ERCC1 enhances cisplatin efficacy in cancer cells☆

(2010) Sanjeevani Arora et al.   DNA REPAIR

Down-regulation of the Nucleotide Excision Repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

(2010) Maria Antonietta Sabatino et al.   Molecular Cancer

Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas

(2009) Hua-Yun Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis

(2009) Bassant M. Barakat et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of transcription by platinum antitumor compounds

(2009) Ryan C. Todd et al.   Metallomics

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation

(2008) H J Jun et al.   BRITISH JOURNAL OF CANCER

ERCC5Is a Novel Biomarker of Ovarian Cancer Prognosis

(2008) Christine S. Walsh et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY