Could SARS-CoV-2-induced lung injury be attenuated by vitamin D?

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Reducing mortality from 2019-nCoV: host-directed therapies should be an option

(2020) Alimuddin Zumla et al.   LANCET

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

2019 Novel Coronavirus (2019-nCoV) Pneumonia

(2020) Peng Liu et al.   RADIOLOGY

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? – Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI)

(2020) Cristian Biscayart et al.   Travel Medicine and Infectious Disease

Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury

(2020) Yuntao Wu   VIROLOGICA SINICA

Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19

(2020) Hao Cheng et al.   JOURNAL OF MEDICAL VIROLOGY

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Understanding the age divide in COVID-19: why are children overwhelmingly spared?

(2020) K. Lingappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human

(2020) Sabyasachi Senapati et al.   JOURNAL OF GENETICS

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Cytokine storm and leukocyte changes in mild versus severe SARS‐CoV‐2 infection: Review of 3939 COVID‐19 patients in China and emerging pathogenesis and therapy concepts

(2020) Jin Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

COVID ‐19 in Parkinson’s Disease Patients Living in Lombardy, Italy

(2020) Alfonso Fasano et al.   MOVEMENT DISORDERS

ACE2 and COVID-19 and the resulting ARDS

(2020) Xiaoqing Zhang et al.   POSTGRADUATE MEDICAL JOURNAL

COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients

(2020) Jerzy Sieńko et al.   Clinical Interventions in Aging

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

(2020) Xingyi Guo et al.   Journal of Translational Medicine

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

The interplay between vitamin D and viral infections

(2019) Majid Teymoori-Rad et al.   REVIEWS IN MEDICAL VIROLOGY

Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis

(2019) Adrian R Martineau et al.   HEALTH TECHNOLOGY ASSESSMENT

N‐Acetyl‐Seryl‐Asparyl‐Lysyl‐Proline interaction with ACE2‐Ang (1‐7)‐Mas axis attenuates pulmonary fibrosis in silicotic rats

(2019) Gao Xuemin et al.   EXPERIMENTAL PHYSIOLOGY

Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone

(2018) Rabab M. Ali et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

(2018) Ming-Dar Lee et al.   Nutrients

The association between vitamin D status and tuberculosis in children

(2018) Xiaoyun Gou et al.   MEDICINE

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system

(2017) Jun Xu et al.   Molecular Medicine Reports

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

(2016) Miao Gui et al.   CELL RESEARCH

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37

(2015) Aline Schögler et al.   EUROPEAN RESPIRATORY JOURNAL

Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier

(2015) YONG-YAN SHI et al.   Molecular Medicine Reports

S67 Vitamin D deficiency drives pulmonary inflammation in a human model of the acute respiratory distress syndrome induced by inhaled lipopolysaccharide in healthy volunteers

(2015) M Fitzgerald et al.   THORAX

Receptor recognition and cross-species infections of SARS coronavirus

(2013) Fang Li   ANTIVIRAL RESEARCH

Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents

(2013) Michelle Science et al.   CLINICAL INFECTIOUS DISEASES

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

(2012) Anna-Winona Struck et al.   ANTIVIRAL RESEARCH

Calcitriol [1, 25[OH]2 D3] pre- and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells

(2012) Drirh Khare et al.   EUROPEAN JOURNAL OF NUTRITION

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

1α,25-Dihydroxyvitamin D3 inhibits neutrophil recruitment in hamster model of acute lung injury

(2011) Yasuhiro Takano et al.   STEROIDS

Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway

(2010) I.-Y. Chen et al.   JOURNAL OF VIROLOGY

TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds

(2009) Shiori Haga et al.   ANTIVIRAL RESEARCH

Vitamin D Deficiency in Older Men

(2009) Eric Orwoll et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D Decreases Respiratory Syncytial Virus Induction of NF- B-Linked Chemokines and Cytokines in Airway Epithelium While Maintaining the Antiviral State

(2009) S. Hansdottir et al.   JOURNAL OF IMMUNOLOGY

Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

(2009) John E. Pak et al.   JOURNAL OF MOLECULAR BIOLOGY

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

(2008) Yumiko Imai et al.   EXPERIMENTAL PHYSIOLOGY

Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice

(2008) Chunlei Zhou et al.   KIDNEY INTERNATIONAL