Article
Engineering, Chemical
Jinglei Liu, Tianfei Chu, Mengmeng Cheng, Yan Su, Guizheng Zou, Shifeng Hou
Summary: An efficient chiral separation membrane was fabricated using bovine serum albumin (BSA) modified graphene oxide (GO) through EDC/NHS coupling chemistry. The BSA modified membrane successfully separated Phe racemate, achieving up to 96.1% excess enantiomer (ee) in the osmotic solution under optimal conditions. The addition of BSA not only increased the spacing in the membrane, but also created chiral channels for selective transport of L-Phe, resulting in high flux and selectivity. The microstructure of BSA was found to be crucial for the chiral separation performance of the membrane, as unfolding of its helical and globular three-dimensional structures weakened or eliminated the separation performance. Molecular docking simulation experiments supported this conclusion.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Food Science & Technology
Xue Zhang, Zihan Sun, Jinxia Liu, Tao Wang, Bolin Zhang, Hongfei Zhao
Summary: The aim of this study was to investigate the influence of bovine serum albumin (BSA) on the Lactobacillus-strain-mediated removal of benzo[a]pyrene (BaP). Combination of BSA with bacterial cells had varying levels of BaP removal for different strains. BSA enhanced the affinity between the bacterial cells and BaP, with its stability and surface properties affecting the binding process.
Article
Engineering, Chemical
Albertina G. Rios, Ana M. Ribeiro, Aliïrio E. Rodrigues, Alexandre F. P. Ferreira
Summary: In this study, the separation of BSA and Mb was achieved using IE-SMB. The adsorption equilibrium of BSA at different salt concentrations was determined by frontal analysis, and a phenomenological mathematical model was validated against fixed-bed dynamic adsorption experiments. The chosen operating conditions were tested experimentally and resulted in high purity, recovery, and productivity.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Albertina G. Rios, Ana M. Ribeiro, Aliïrio E. Rodrigues, Alexandre F. P. Ferreira
Summary: The separation of bovine serum albumin and myoglobin was achieved using ion-exchange simulated moving bed. The study demonstrates the possibility of obtaining high purity, recovery, and productivity under specific operating conditions.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Environmental
Chunlian Hu, Wei Zhang, Yuantao Chen, Na Ye, DaWa YangJi, Haizhe Jia, Yanting Shen, Minna Song
Summary: The carboxylated sludge biochar (CSB) modified by HNO3 showed improved adsorption capacity for the removal of cobalt, making it a promising adsorbent for wastewater treatment.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Ningsi Wei, Jisheng Yang, Kaiqiang Dong, Yanyuan Fang, Zhiyong Quin
Summary: This study fabricated bovine serum albumin amyloid fibril aerogels, and by adding branched polyethyleneimine, the mechanical properties and adsorption capacity of the adsorbents were improved significantly. The maximum adsorption capacity of the aerogel was found to be 3.01 times higher than that of pure protein aerogel for Cu (II), and it also showed good adsorption quantity for other heavy metal ions and organic pollutants.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Instruments & Instrumentation
Ruiduo Wang, Hao Wu, Mei Qi, Jing Han, Zhaoyu Ren
Summary: This study demonstrated a biosensor for bovine serum albumin (BSA) detection using a graphene oxide (GO) functionalized micro-taped long-period fiber grating (GMLPG). The GO-BSA connection allowed BSA to attach onto the fiber surface, changing the refractive index and enabling BSA concentration measurement. The sensor showed high sensitivity, low detection limit, and superior measurement performance in the presence of glucose and urea interferents.
Article
Engineering, Environmental
Jiangbo Huo, Guoce Yu, Jianlong Wang
Summary: By preparing a composite of polyvinyl alcohol, graphene oxide, and MnO2, the adsorbent showed enhanced adsorption capacity for Co2+ and Sr2+. The composite exhibited high adsorption capacity under different pH conditions and different responses to interfering substances in competitive adsorption tests.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biology
Andrew J. Stout, Addison B. Mirliani, Miriam L. Rittenberg, Michelle Shub, Eugene C. White, John S. K. Yuen, David L. Kaplan
Summary: Cell-cultured meat offers the potential for a more sustainable, ethical, resilient, and healthy food system. This study developed a low-cost serum-free media (Beefy-9) by adapting the B8 media for bovine satellite cells, enabling long-term satellite cell expansion without sacrificing myogenicity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pei-Xuan Lee, Bing-Lan Liu, Pau Loke Show, Chien Wei Ooi, Wai Siong Chai, Heli Siti Halimatul Munawaroh, Yu-Kaung Chang
Summary: In this study, PAN nanofiber membrane was used as the basic matrix for synthesizing cation-exchange nanofiber membranes with different properties. The P COOH-BSA membrane showed the highest removal efficiency of Ca2+ at specific conditions. The dynamic adsorption system indicated effective removal of Ca2+ by these nanofiber membranes with high interface mass transfer. The Thomas model was found to be more suitable in explaining the trends observed in the experimental results.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Abdulrahman Abu-Nada, Ahmed Abdala, Gordon McKay
Summary: Graphene oxide (GO) was successfully synthesized and characterized in this study, showing excellent adsorption capability for removing Sr (II) from aqueous solutions. The adsorption equilibrium and kinetic results were in agreement with the Langmuir isotherm model and the pseudo-second-order kinetic model. The maximum strontium adsorption capacity reached 131.4 mg/g, suggesting potential applications in wastewater treatment.
Article
Polymer Science
Simge Ozturk, Nalan Demir
Summary: In this paper, the adsorption process of bovine serum albumin (BSA) on the [p(HEMA)-g-CTS]/MMT superabsorbent nanocomposite was investigated. The [p(HEMA)-g-CTS]/MMT superabsorbent nanocomposite was synthesized using free radical polymerization. Various techniques, such as FTIR, SEM, TGA, and swelling test, were employed to characterize the structure of the synthesized [p(HEMA)-g-CTS]/MMT superabsorbent nanocomposite. The influence of adsorption parameters on the adsorption process was evaluated and the results showed that the superabsorbent nanocomposite had a high affinity to BSA.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Ana F. C. S. Rufino, Mafalda R. Almeida, Mukesh Sharma, Joao A. P. Coutinho, Mara G. Freire
Summary: With a novel ionic-liquid-based aqueous biphasic system, efficient extraction and separation of bovine serum albumin (BSA) from bovine serum was achieved, with a recovery yield of 85.6% and purity of 61.2% under optimal conditions. The system shows potential as a platform for purifying BSA from serum samples and can be applied to other valuable proteins.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Xiaocong He, Lingxiao Li, Yuanyuan Yang, Zhaotong Dong, Lin Wang, Zhiguo Qu, Feng Xu
Summary: By conducting molecular dynamics simulations between patchy nanoparticles and human serum albumin, it was found that there is a high probability of interaction between HSA and the hydrophobic or charged brushes of the patchy nanoparticles. The adsorption sites depend on the surface properties of the NPs, and the adsorption of HSA on NPs can improve the interaction between NPs and cell membranes.
Article
Biophysics
Neha S. Ekal, Rahul Patil, Nihar Ranjan, Pratap Bahadur, Sanjay Tiwari
Summary: In this study, the interaction between bovine serum albumin (BSA) and oxidized graphene oxide (GO) nanosheets was explored. The extent of sheet oxidation and the availability of pure graphitic domains were found to play important roles in regulating the interactions. Additionally, the adsorption of proteins as colloidal aggregates was shown to improve the biosafety of the nanosheets.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Sheetal Sharma, Panchali Barman, Shubhi Joshi, Simran Preet, Avneet Saini
Summary: The challenges of decreasing effectiveness of conventional drugs due to multidrug-resistance are exacerbated by the widespread use of antimicrobial drugs during the COVID-19 pandemic. It is crucial to develop novel antimicrobial agents to combat the looming crisis of multidrug resistance. Antimicrobial peptides show promise as next-generation therapeutics with unique mechanisms of action and low resistance development.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Liza Gupta, Pooja Khanna Sood, Bimla Nehru, Sheetal Sharma
Summary: This study found that palm oil has significant effectiveness in preventing aluminum-induced brain damage in rats, reducing oxidative stress and neurotoxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Pratibha Sharma, Sheetal Sharma, Shubhi Joshi, Panchali Barman, Aashish Bhatt, Mayank Maan, Neha Singla, Praveen Rishi, Md Ehesan Ali, Simran Preet, Avneet Saini
Summary: The emergence of multidrug resistance and the decrease in the development of antibiotics have led to an increased demand for antimicrobials with novel mechanisms of action. Researchers are striving to develop new antimicrobial substances to alleviate the pressure on conventional antibiotic therapies. Host-Defence Peptides (HDPs) and their derivatives are showing promise as effective therapeutic agents against microbial resistance and may have potential clinical applications.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Ankita Bhardwaj, Rishi Bhardwaj, Avneet Saini, Devinder Kumar Dhawan, Tanzeer Kaur
Summary: This study demonstrates that excessive activation of AMPA receptors leads to increased intracellular calcium levels in neurons, causing excitotoxicity. The endoplasmic reticulum (ER) plays a crucial role in maintaining calcium homeostasis. The findings also suggest that AMPA toxicity impairs protein folding capacity of the ER, leading to ER stress and disruption of calcium balance.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Physical
Prabhsharan Kaur, Stuti Jaiswal, Divya Manhas, Veerpal Kaur, Vasudeo Babar, Gaurav Verma
Summary: In this study, carbon nanofibers (CNF) were treated with fresh neem leaves (FNL) and their dispersion treatment using Triton X-100 was investigated. The results showed that the CNF morphology remained intact after organic treatment, and the CNF was functionalized with heteroatoms and nutrients from FNL. The modified CNF exhibited good electrocatalytic activity for oxygen reduction reaction (ORR) in alkaline medium, and the cup-stacked CNF showed the most active sites for the ORR catalysis.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Prapti Kakkar, Shivanshu Mishra, Anjali Sharma, Mohammad Babar, Rupali Verma, Gaurav Verma
Summary: Dispersion of nanofiller in the polymer matrix is a critical factor in determining the properties of nanocomposites. Traditional characterization techniques lack the ability to analyze mixing on a larger scale, while conducting such testing at the industrial level is costly and time-consuming. This study proposes a simple method using a camera and deep learning models to examine dispersion. Different processing techniques significantly affect dispersion due to the different mixing mechanisms involved. Deep learning models provide a holistic viewpoint and improve interpretation by uncovering hidden information.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Mohammad Babar, Gaurav Verma
Summary: This article discusses how processing bias affects polymer chain dynamics in 2D nanofiller interfaces, and highlights the significant improvement in thermal and mechanical properties of polyurethane-2D clay nanocomposite coatings. The study examines the nanoscale structure and interface formation between 2D clay and PU chains, and uses gold sputtered patterns in FESEM images to analyze PU chain dynamics. The findings confirm the presence of an attractive interface between PU and 2D nanoclay, and show that reinforcing nanoclay enhances polymer chain dynamics and morphology.
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
(2023)
Article
Chemistry, Applied
Mohammad Babar, Gaurav Verma
Summary: Cloisite 20A-polyurethane (C20-PU) nanocomposites were prepared using three processing schemes at different reinforcement levels. The H-bonding chemistry between PU and C20 led to a compartment effect in C20-PU, affecting the mechanical performance. By switching the sequence of homogenizer (HSH) and ultrasonic bath (USB), elastic and plastic nanocomposites were produced, with significant changes in the plasticity index. DMA studies showed improved thermomechanical properties in C20-PU nanocomposites, with a right shift in the glass transition temperature (Tg) and reduced Tg peak intensities.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Pharmacology & Pharmacy
Sandeep Saini, Aayushi Rathore, Sheetal Sharma, Avneet Saini
Summary: In this study, exploratory data analysis (EDA) was conducted on the physicochemical parameters of antimicrobial peptides (AMPs) and anticancer peptides (ACPs). The analysis revealed selectivity in the length and amino acid compositions of AMPs and ACPs. The distribution of physicochemical parameters within defined quartile ranges and the preferred length range of 21-30 amino acids were observed.
Article
Biochemistry & Molecular Biology
Panchali Barman, Shubhi Joshi, Sheetal Sharma, Simran Preet, Shweta Sharma, Avneet Saini
Summary: In recent years, there has been a growing interest in alternate therapies due to the occurrence of drug-resistant diseases. Peptide-based drugs have gained attention in various therapeutic fields and their limitations have been addressed through modification strategies. This article aims to cover the missing links in the literature by discussing different aspects of peptide-based therapeutics, with a focus on in-silico approaches and modification-based peptide design strategies.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
