Designed variants of ACE2-Fc that decouple anti-SARS-CoV-2 activities from unwanted cardiovascular effects

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COVID-19 and the cardiovascular system

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Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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COVID-19, ACE2, and the cardiovascular consequences

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COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

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Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19

(2020) Matthew A. Sparks et al.   Clinical Journal of the American Society of Nephrology

COVID-19 and Multiorgan Response

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Post‐mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction

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ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective

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The case of Complement activation in COVID-19 multiorgan impact

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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

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Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

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Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

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Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

(2020) Changhai Lei et al.   Nature Communications

Coronavirus Disease 2019 (COVID‐19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

(2020) Junyi Guo et al.   Journal of the American Heart Association

Coronavirus Disease 2019 (COVID‐19): Do Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

(2020) Rami Sommerstein et al.   Journal of the American Heart Association

Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers

(2020) Chirag Bavishi et al.   JAMA Cardiology

Renin-Angiotensin System Blockers and the COVID-19 Pandemic

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Coronaviruses pathogenesis, comorbidities and multi-organ damage – A review

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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

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The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation

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SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

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The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials

(2020) Eugenie R. Lumbers et al.   Frontiers in Medicine

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

(2020) Pawel Namsolleck et al.   MOLECULAR MEDICINE

A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension

(2018) Anna R. Hemnes et al.   EUROPEAN RESPIRATORY JOURNAL

Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation

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A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13

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Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations

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