Article
Cardiac & Cardiovascular Systems
Justin B. Echouffo-Tcheugui, Sui Zhang, Natalie Daya, John W. McEvoy, Olive Tang, Stephen P. Juraschek, Chiadi E. Ndumele, Josef Coresh, Robert H. Christenson, Elizabeth Selvin
Summary: NT-proBNP is strongly associated with mortality in patients with heart failure. In a representative sample of the US adult population, NT-proBNP was an important independent risk factor for all-cause and cardiovascular disease mortality, and may be useful for monitoring risk in the general adult population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Aliza Hussain, Wensheng Sun, Anita Deswal, James A. de Lemos, John W. McEvoy, Ron C. Hoogeveen, Kunihiro Matsushita, David Aguilar, Biykem Bozkurt, Salim S. Virani, Amil M. Shah, Elizabeth Selvin, Chiadi Ndumule, Christie M. Ballantyne, Vijay Nambi
Summary: Elevated NT-proBNP is independently associated with increased CVD risk and can help identify individuals at higher risk, especially in those with stage 1 hypertension but elevated NT-proBNP levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Bernard Srour, Rudolf Kaaks, Theron Johnson, Lucas Cory Hynes, Tilman Kuehn, Verena A. Katzke
Summary: The study found associations between markers of unhealthy aging and risks of cancer and cardiovascular disease, with some markers showing positive associations with specific diseases and others showing negative associations. Additionally, combinations of these markers showed moderately strong associations with the risks of cancer and CVD.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Caro-Codon, Juan R. Rey, Antonio Buno, Angel M. Iniesta, Sandra O. Rosillo, Sergio Castrejon-Castrejon, Laura Rodriguez-Sotelo, Luis A. Martinez, Irene Marco, Carlos Merino, Lorena Martin-Polo, Jose M. Garcia-Veas, Marcel Martinez-Cossiani, Luis Gonzalez-Valle, Alicia Herrero, Esteban Lopez-de-Sa, Jose L. Merino
Summary: Research has shown that NT-proBNP levels are frequently elevated in COVID-19 patients and are strongly associated with prognosis.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Lidia Staszewsky, Jennifer M. T. A. Meessen, Deborah Novelli, Ursula-Henrike Wienhues-Thelen, Marcello Disertori, Aldo P. Maggioni, Serge Masson, Gianni Tognoni, Maria Grazia Franzosi, Donata Lucci, Roberto Latini
Summary: Novel circulating biomarkers may help in understanding AF mechanisms. The study found total NT-proBNP, NT-proBNP, Ang2, and BMP10 were strongly associated with ongoing AF and predictive of recurrent AF and CV hospitalization. The association of total NT-proBNP with AF first recurrence was similar to NT-proBNP, suggesting no influence of glycosylation.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medical Laboratory Technology
Moises Rodriguez-Gonzalez, Lorena Estepa-Pedregosa, Ana Estalella-Mendoza, Ana Castellano-Martinez, Patricia Rodriguez-Campoy, Jose Carlos Flores-Gonzalez
Summary: In infants with bronchiolitis, elevated NT-proBNP but not hs-cTnI is associated with disease severity, need for PICU admission, and echocardiographic cardiac dysfunction, suggesting that NT-proBNP may be a useful biomarker for myocardial strain in this population.
CLINICA CHIMICA ACTA
(2021)
Article
Cardiac & Cardiovascular Systems
Man Wang, Wen Su, Hui Chen, Hongwei Li
Summary: This study aimed to examine the joint association of diabetes status and NT-proBNP with subsequent risk of MACCEs and all-cause mortality in patients with NSTE-ACS. The study found that diabetes and higher levels of NT-proBNP were independently associated with the risk of MACCEs and all-cause mortality, and the highest risks were observed in patients with diabetes and NT-proBNP ≥336 pg/ml.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Oncology
Elodie Jobard, Laure Dossus, Laura Baglietto, Marco Fornili, Lucie Lecuyer, Francesca Romana Mancini, Marc J. Gunter, Olivier Tredan, Marie-Christine Boutron-Ruault, Benedicte Elena-Herrmann, Gianluca Severi, Joseph A. Rothwell
Summary: Perturbations in circulating metabolites were observed in premenopausal but not postmenopausal breast cancer cases. Metabolites such as histidine, N-acetyl glycoproteins, glycerol, and ethanol were associated with breast cancer risk, particularly in the premenopausal subgroup.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Yiling Yao, Li Feng, Yanxiang Sun, Shifei Wang, Jie Sun, Bing Hu
Summary: NT-proBNP, sST2, and PIIINP have been identified as independent prognostic factors for all-cause mortality in ADHF patients. In addition, the combination of NT-proBNP and PIIINP may offer incremental prognostic value over NT-proBNP alone in predicting survival in ADHF patients.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Cardiac & Cardiovascular Systems
Man Wang, Li Zhou, Wen Su, Wenxi Dang, Hongwei Li, Hui Chen
Summary: The elevated triglyceride-glucose (TyG) index and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are independently associated with an increased risk of major adverse cardio-cerebral events (MACCEs) in diabetic patients with acute coronary syndrome (ACS). This study investigated the independent and joint association of these two markers with MACCEs risk. The findings suggest that diabetic ACS patients with elevated levels of both TyG index and NT-proBNP are at the highest risk of MACCEs.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hui-Hui Liu, Ye-Xuan Cao, Jing-Lu Jin, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Yan Zhang, Rui-Xia Xu, Qian Dong, Jian-Jun Li
Summary: The study found that high levels of NT-proBNP were significantly associated with MACEs in patients with prediabetes mellitus (pre-DM) or diabetes mellitus (DM), but not in patients with normoglycemia. NT-proBNP can serve as an independent predictor of adverse outcomes in dysglycemic patients with CCS and normal LVSF.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Anesthesiology
Christian Reiterer, Barbara Kabon, Alexander Taschner, Markus Falkner von Sonnenburg, Alexandra Graf, Nikolas Adamowitsch, Patrick Starlinger, Julius Goshin, Melanie Fraunschiel, Edith Fleischmann
Summary: In a randomized trial involving 260 patients undergoing major abdominal surgery, no significant difference was found in postoperative NT-proBNP concentration and the incidence of MINS between the group receiving 80% oxygen and the group receiving 30% oxygen during and after surgery.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Wenjing Ye, Xi Chen, Xiaoming Li, Xuejun Guo, Wen Gu
Summary: This study aimed to predict the status of the pulmonary circulation and arterial gas exchange functions in patients with acute pulmonary embolism (APE) using serum levels of cardiac biomarkers and arterial oxygenation index (OI) values. The results showed significant correlations between cardiac biomarkers, OI, pulmonary artery pressure (PAP), and ventilation/perfusion (V/Q) mismatch. Arterial OI and serum levels of cardiac biomarkers may serve as indicators of pulmonary hypertension and V/Q mismatch.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Satoshi Saito, Masafumi Ihara, Daisuke Matsui, Isao Watanabe, Masaki Kondo, Yoshinori Marunaka, Akihiro Takada, Kentaro Akazawa, Satomi Tomida, Reo Nagamitsu, Fumitaro Miyatani, Masahiro Miyake, Eri Nakano, Daiki Kobayashi, Yoshiyuki Watanabe, Shigeto Mizuno, Mizuho Maekawa, Tamami Yoshida, Yukiko Nukaya, Toshiki Mizuno, Kei Yamada, Ritei Uehara
Summary: This study examined the association between levels of mid-regional pro-adrenomedullin (MR-proADM) and cerebral microbleeds (MBs), finding that high levels of MR-proADM may be linked to the identification of MBs and cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Endocrinology & Metabolism
Evelyne Liuu, Pierre-Jean Saulnier, Elise Gand, Gautier Defossez, Amelie Jamet, Stephanie Ragot, Marc Paccalin, Samy Hadjadj
Summary: This study investigated whether diabetic micro- and macrovascular complications (mMVC) influence cancer-related events in people with type 2 diabetes. The findings showed that mMVC were not associated with cancer-related events, but a personal history of cancer was significantly associated with cardiovascular death.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Louis Potier, Kamel Mohammedi, Pierre-Jean Saulnier, Frederic Fumeron, Jean-Michel Halimi, Nicolas Venteclef, Michel Marre, Samy Hadjadj, Ronan Roussel, Gilberto Velho
Summary: ADM is associated with the risk of lower-limb amputation (LLA) in people with type 2 diabetes. SNPs in the ADM gene region are also associated with ADM and LLA risk.
Letter
Endocrinology & Metabolism
Vincent Rigalleau, Marie-Amelie Barbet-Massin, Alice Larroumet, Kamel Mohammedi, Laurence Baillet-Blanco, Marie Monlun, Blandine Cherifi, Ninon Foussard
Letter
Endocrinology & Metabolism
Vincent Rigalleau, Alice Larroumet, Kamel Mohammedi, Laurence Baillet-Blanco, Marie Monlun, Marie-Noelle Delyfer, Jean-Francois Korobelnik, Ninon Foussard
Article
Urology & Nephrology
Hiroki Kobayashi, HelenC. Looker, Eiichiro Satake, Pierre Jean Saulnier, Zaipul I. Dom, Kristina O'Neil, Katsuhito Ihara, Bozena Krolewski, Andrzej T. Galecki, Monika A. Niewczas, Jonathan M. Wilson, Alessandro Doria, Kevin L. Duffin, Robert G. Nelson, Andrzej S. Krolewski
Summary: This study utilizes a large proteomics panel to search for new circulating biomarkers associated with progression to kidney failure in individuals with diabetic kidney disease. The researchers identified 11 proteins that were significantly associated with the progression to kidney failure and found that some of these proteins were related to neuron development and kidney fibrosis. Further investigation is needed to understand the specific mechanisms of these proteins in the progression of diabetic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Samy Hadjadj, Pierre-Jean Saulnier, Yue Ruan, Xu Zhu, Renee Pekmezaris, Michel Marre, Jean Michel Halimi, Matthieu Wargny, Rustam Rea, Pierre Gourdy, Bertrand Cariou, Alyson K. Myers, Kamlesh Khunti
Summary: Microvascular complications are associated with increased risk of death in patients hospitalized for COVID-19.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Ninon Foussard, Paul Rouault, Lauriane Cornuault, Annabel Reynaud, Emmanuel S. Buys, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Kamel Mohammedi, Marie-Ange Renault
Summary: This study evaluated the effect of praliciguat on the recovery of lower limb ischemia in a mouse model of type 2 diabetes. The results showed that praliciguat treatment improved foot perfusion and function parameters in mice compared to the control group. Additionally, praliciguat treatment increased arteriole diameter, decreased ICAM1 expression, and prevented the accumulation of oxidative proangiogenic and proinflammatory muscle fibers.
CIRCULATION RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Stewart B. Harris, Kamel Mohammedi, Monica Bertolini, John White, Valery Walker, Fang Liz Zhou, John E. Anderson, Jochen Seufert
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amelie Barbet-Massin, Claire Ducos, Marine Rigo, Lila Rami Arab, Frederic Domenge, Kamel Mohammedi, Eric Ducasse, Caroline Caradu, Marie-Noelle Delyfer, Jean-Francois Korobelnik, Vincent Rigalleau
Summary: This study investigates the relationship between diabetic retinopathy (DR) and the development of diabetic foot ulcers (DFU). It finds that DR is associated with a higher incidence of DFUs.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Kamel Mohammedi, Eric Ducasse, Caroline Caradu, Vincent Rigalleau
Summary: In individuals with diabetic kidney disease, there is a relationship between DKD and later occurrence of diabetic foot ulcers, while normoalbuminuric DKD is not related to diabetic foot ulcers.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Cell Biology
Kamel Mohammedi, Michel Marre, Samy Hadjadj, Louis Potier, Gilberto Velho
Summary: This study is the first to report an independent association between redox GRS and increased risk of ESKD in type 1 diabetes. The results suggest that while the redox GRS is associated with ESKD risk, it does not provide significant improvement in predicting ESKD compared to clinical factors.
Article
Oncology
Julie Tisserand, Violaine Randrian, Marc Paccalin, Pierre-Jean Saulnier, Marine Arviset, Arthur Fourmy, Victor Arriudarre, Amelie Jamet, Yvan Moreno, Simon Valero, Evelyne Liuu
Summary: Iron deficiency is common in older patients with solid tumors. In the absence of anemia, iron deficiency is associated with better survival, but when combined with anemia, it is associated with increased mortality. The study questions the value of iron supplementation therapy in older patients with cancer.
Article
Surgery
Heloise Ducousso, Maxime Vallee, Thomas Kerforne, Ines Castilla, Fabien Duthe, Pierre-Jean Saulnier, Stephanie Ragot, Antoine Thierry
Summary: Plasma creatinine is a marker of interest in renal transplantation, and this study aimed to identify clinically relevant subgroups of creatinine trajectories following renal transplantation and their association with graft outcome. Four distinct classes of creatinine trajectories were identified, and there was substantial heterogeneity in these trajectories. The study highlights the importance of identifying patients who are more likely to experience graft loss.
TRANSPLANT INTERNATIONAL
(2023)