Non-conventional dysplasias of the tubular gut: a review and illustration of their histomorphological spectrum

The increasing use of gastrointestinal endoscopic procedures has led to the recognition by histopathologists of non-conventional (or special-type) dysplasias of the gastrointestinal tract. These lesions can be recognised in association with prevalent underlying gastrointestinal conditions, such as Barrett oesophagus, chronic atrophic gastritis, and inflammatory bowel disease. The diagnosis of these special types can be challenging, and their biological behaviours are not fully characterised. The aim of this review is to provide a global view of non-conventional dysplastic lesions observed in the various segments of the tubular gastrointestinal tract and describe their salient features. Furthermore, as the clinical implications of these various subtypes have not been broadly tested in practice and are not represented in most management guidelines, we offer guidance on the best management practices for these lesions.

Automated summary

The increasing use of gastrointestinal endoscopic procedures has led to the recognition of non-conventional dysplasias of the gastrointestinal tract by histopathologists. These lesions are often associated with prevalent underlying gastrointestinal conditions and may present diagnostic challenges with poorly characterized biological behaviors. This review aims to provide a comprehensive overview of non-conventional dysplastic lesions in the tubular gastrointestinal tract and offer guidance on best management practices for these lesions, which are not widely tested in practice or represented in most management guidelines.