Journal
GENES & DEVELOPMENT
Volume 34, Issue 23-24, Pages 1577-1598Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.343251.120
Keywords
cancer therapeutics; metastasis; stress; tumor microenvironment
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Funding
- Susan G. Komen Foundation
- New Jersey Commission on Cancer Research
- Brewster Foundation
- American Cancer Society
- Breast Cancer Research Foundation
- National Institutes of Health
- U.S. Department of Defense
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Metastasis is the ultimate survival of the fittest test for cancer cells, as only a small fraction of disseminated tumor cells can overcome the numerous hurdles they encounter during the transition from the site of origin to a distinctly different distant organ in the face of immune and therapeutic attacks and various other stresses. During cancer progression, tumor cells develop a variety of mechanisms to cope with the stresses they encounter, and acquire the ability to form metastases. Restraining these stress-releasing pathways could serve as potentially effective strategies to prevent or reduce metastasis and improve the survival of cancer patients. Here, we provide an overview of the tumor-intrinsic, microenvironmentand treatment-induced stresses that tumor cells encounter in the metastatic cascade and the molecular pathways they develop to relieve these stresses. We also summarize the preclinical and clinical studies that evaluate the potential therapeutic benefit of targeting these stress-relieving pathways.
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