N-heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015–2020)

Synthesis, Structure, and Anticancer Activity of Symmetrical and Non-symmetrical Silver(I)-N-Heterocyclic Carbene Complexes

(2020) Muhammad Atif et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Synthesis of theophylline-based iridium(I) N-heterocyclic carbene complexes including fluorinated-thiophenolate ligands. Preliminary evaluation of their in vitro anticancer activity

(2020) Itzel Eslava-Gonzalez et al.   INORGANICA CHIMICA ACTA

The effect of short alkane bridges in stability of bisbenzimidazole-2-ylidene silver(I) complexes: Synthesis, crystal structure and antibacterial activity

(2019) Yen L. Loh et al.   JOURNAL OF COORDINATION CHEMISTRY

N-Heterocyclic Carbenes in Materials Chemistry

(2019) Christene A. Smith et al.   CHEMICAL REVIEWS

N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction

(2019) Sébastien Harlepp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NHC-Ir(I) complexes derived from 5,6-dinitrobenzimidazole. Synthesis, characterization and preliminary evaluation of their in vitro anticancer activity

(2019) Arturo Sánchez-Mora et al.   INORGANICA CHIMICA ACTA

New class of non-symmetrical homo-dibenzimidazolium salts and their dinuclear Silver(I) di-NHC complexes

(2019) Umie F.M. Haziz et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Chiral N-heterocyclic Carbene Gold Complexes: Synthesis and Applications in Catalysis

(2019) Michalak et al.   Catalysts

A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression

(2019) Rong Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Palladium complexes of bidentate pyridine N -heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

(2018) Kar Bee Choo et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands

(2018) Wojciech Streciwilk et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis and characterization of nitrile functionalized silver(I)- N -heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus

(2018) Patrick O. Asekunowo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Palladium(II) N-heterocyclic carbene complexes: Synthesis, structures and cytotoxicity potential studies against breast cancer cell line

(2018) Sunusi Y. Hussaini et al.   JOURNAL OF COORDINATION CHEMISTRY

Sterically modulated silver(I) complexes of coumarin substituted benzimidazol–2–ylidenes: Synthesis, crystal structures and evaluation of their antimicrobial and antilung cancer potentials

(2018) Gautam Achar et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Antibacterial and DNA cleavage activity of carbonyl functionalized N -heterocyclic carbene-silver(I) and selenium compounds

(2018) Rosenani A. Haque et al.   JOURNAL OF MOLECULAR STRUCTURE

Benzoxazole and dioxolane substituted benzimidazole–based N –heterocyclic carbene–silver(I) complexes: Synthesis, structural characterization and in vitro antimicrobial activity

(2018) C.R. Shahini et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis and anticancer activity of novel NHC-gold(I)-sugar complexes

(2018) Oyinlola Dada et al.   TETRAHEDRON LETTERS

Nitrile functionalized silver(I) N-heterocyclic carbene complexes: DFT calculations and antitumor studies

(2018) Sunusi Y. Hussaini et al.   TRANSITION METAL CHEMISTRY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A

(2018) Danielle Curran et al.   MOLECULES

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis, structures and anticancer studies of symmetrically and non-symmetrically aliphatic nitrile functionalized silver(I)-N-heterocyclic carbene and palladium(II)-N-heterocyclic carbene complexes

(2018) Sunusi Y. Hussaini et al.   Inorganic and Nano-Metal Chemistry

Synthesis, structures and antimicrobial activity of novel NHC∗- and Ph3P-Ag(I)-Benzoate derivatives

(2018) Cillian O'Beirne et al.   INORGANICA CHIMICA ACTA

Novel lysosome-targeted cyclometalated Iridium(III) anticancer complexes containing imine-N-heterocyclic carbene ligands: Synthesis, spectroscopic properties and biological activity

(2018) Yuliang Yang et al.   DYES AND PIGMENTS

Synthesis, characterization, crystal structure and in vitro anticancer potentials of mono and bimetallic palladium(II)–N–heterocyclic carbene complexes

(2017) Mohammed Z. Ghdhayeb et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Synthesis, structural investigation and antibacterial studies of non–symmetrically p –nitrobenzyl substituted benzimidazole N –heterocyclic carbene–silver(I) complexes

(2017) C.R. Shahini et al.   INORGANICA CHIMICA ACTA

Non-symmetrically p-nitrobenzyl- and p-cyanobenzyl-substituted N-heterocyclic carbene-silver(I) complexes: synthesis, characterization and antibacterial studies

(2017) T. V. Subramanya Prasad et al.   JOURNAL OF COORDINATION CHEMISTRY

Synthesis, Characterization and Antimicrobial properties of Methylbenzyl and Nitrobenzyl containing Imidazolium-based Silver N -Heterocyclic Carbenes

(2017) Sainath Aher et al.   JOURNAL OF MOLECULAR LIQUIDS

Tetra N -heterocyclic carbene dinuclear silver(I) complexes as potential anticancer agents: Synthesis and in vitro anticancer studies

(2017) Tabinda Fatima et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, structural characterization, crystal structures and antibacterial potentials of coumarin–tethered N–heterocyclic carbene silver(I) complexes

(2017) Gautam Achar et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis and cytotoxicity studies of novel NHC–Gold(I) pseudohalides and thiolates

(2017) Oyinlola Dada et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines

(2017) Senem Akkoç et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, characterization and anti-proliferative activity of propylene linked bis-benzimidazolium salts and their respective dinuclear Silver(I)- N -heterocyclic carbene complexes

(2017) Sunusi Y. Hussaini et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Mono- and bis-N-heterocyclic carbene silver(I) and palladium(II) complexes: Synthesis, characterization, crystal structure and in vitro anticancer studies

(2017) Mohammed Z. Ghdhayeb et al.   POLYHEDRON

Synthesis, characterization, crystal structure and biological studies of silver(I) complexes derived from coumarin-tethered N-heterocyclic carbene ligands

(2017) Gautam Achar et al.   POLYHEDRON

Synthesis, characterization, crystal structure, and antimicrobial studies of 2-morpholinoethyl-substituted benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes

(2017) Işıl Yıldırım et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Synthesis, characterization and antimicrobial activities of novel silver(I) complexes with coumarin substituted N-heterocyclic carbene ligands

(2016) Mert Olgun Karataş et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes

(2016) Yvonne Gothe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies

(2016) Gwo Yaw Ho et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action

(2016) Jing-Jing Zhang et al.   DALTON TRANSACTIONS

The Platin-X series: activation, targeting, and delivery

(2016) Uttara Basu et al.   DALTON TRANSACTIONS

Human colon cancer targeted pro-apoptotic, anti-metastatic and cytostatic effects of binuclear Silver(I)– N -Heterocyclic carbene (NHC) complexes

(2016) Muhammad Asif et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structure,in vitroanticancer andin vivoacute oral toxicity studies of tetramethylene linked bis-benzimidazolium salts and their respective dinuclear Ag(I)–NHC complexes

(2016) Tabinda Fatima et al.   JOURNAL OF COORDINATION CHEMISTRY

In vitroantimicrobial studies of new benzimidazolium salts and silverN-heterocyclic carbene complexes

(2016) Yetkin Gök et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, characterization, and structure–activity relationship of the antimicrobial activities of dinuclear N -heterocyclic carbene (NHC)-silver(I) complexes

(2016) Ryosuke Sakamoto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

(2016) Wolfgang Walther et al.   Letters in Drug Design & Discovery

Targeted therapy: An elusive cancer target

(2016) Carolyn Brown   NATURE

New non-functionalized and nitrile-functionalized benzimidazolium salts and their silver(I) complexes: Synthesis, crystal structures and antibacterial studies

(2016) Rosenani A. Haque et al.   POLYHEDRON

Synthesis, structures and antibacterial studies of non-functionalized and nitrile-functionalized bis-benzimidazolium salts and respective dinuclear silver(I)- N -heterocyclic carbene complexes

(2016) Umie F.M. Haziz et al.   POLYHEDRON

Synthesis of a palladium(II) complex of a N-heterocylic carbene via transmetalation: crystal structure and antibacterial studies

(2016) Rosenani A. Haque et al.   TRANSITION METAL CHEMISTRY

Synthesis, crystal structures, and in vitro anticancer properties of new N-heterocyclic carbene (NHC) silver(i)- and gold(i)/(iii)-complexes: a rare example of silver(i)–NHC complex involved in redox transmetallation

(2016) Rosenani A. Haque et al.   RSC Advances

Bis-N-heterocyclic carbene silver(I) and palladium(II) complexes: Efficient antiproliferative agents against breast cancer cells

(2016) Rosenani A. Haque et al.   Inorganic and Nano-Metal Chemistry

N-heterocyclic carbene complexes of Group 6 metals

(2015) Zhe Wang et al.   COORDINATION CHEMISTRY REVIEWS

N-heterocyclic carbene metal complexes as bio-organometallic antimicrobial and anticancer drugs

(2015) Siddappa A Patil et al.   Future Medicinal Chemistry

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

(2015) Luciano Oehninger et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro antimicrobial studies of naphthalen-1-ylmethyl substituted silver N-heterocyclic carbene complexes

(2015) Yetkin Gök et al.   Arabian Journal of Chemistry

Antibiotic Resistance of Bacteria

(2015) Madhab K. Chattopadhyay et al.   Biomed Research International

Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes

(2014) Anant R. Kapdi et al.   CHEMICAL SOCIETY REVIEWS

Review of therapeutic drug monitoring of anticancer drugs part two – Targeted therapies

(2014) Nicolas Widmer et al.   EUROPEAN JOURNAL OF CANCER

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Sterically modulated silver(I) complexes of N-benzyl-substituted N-heterocyclic carbenes: synthesis, crystal structures and bioactivity

(2014) Patrick O. Asekunowo et al.   TRANSITION METAL CHEMISTRY

Development of anticancer drugs based on the hallmarks of tumor cells

(2014) Natalia Bailón-Moscoso et al.   TUMOR BIOLOGY

Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro

(2013) Melis Debreli Coskun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

N-heterocyclic carbene transition metal complexes for catalysis in aqueous media

(2012) Heriberto Diaz Velazquez et al.   CHEMICAL SOCIETY REVIEWS

Abnormal, mesoionic and remote N-heterocyclic carbene complexes

(2012) Robert H. Crabtree   COORDINATION CHEMISTRY REVIEWS

N-Heterocyclic carbene metal complexes in medicinal chemistry

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

Rhodium(III) and iridium(III) complexes as anticancer agents

(2012) Yvonne Geldmacher et al.   INORGANICA CHIMICA ACTA

Ruthenium Nanoparticles Stabilized by N-Heterocyclic Carbenes: Ligand Location and Influence on Reactivity

(2011) Patricia Lara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The crisis of no new antibiotics—what is the way forward?

(2011) Laura JV Piddock   LANCET INFECTIOUS DISEASES

Steering the Surprisingly Modular π-Acceptor Properties of N-Heterocyclic Carbenes: Implications for Gold Catalysis

(2010) Manuel Alcarazo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-based chemotherapeutics: are they ready for prime time?

(2010) Emmanuel S. Antonarakis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

(2010) Laszlo Mercs et al.   CHEMICAL SOCIETY REVIEWS

The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

(2010)   CLINICAL INFECTIOUS DISEASES

Coping with antibiotic resistance: the impending crisis

(2010) I.M. Gould   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Electronic properties of chelating dicarbene palladium complexes: A combined electrochemical, NMR and XPS investigation

(2010) Gabriella Buscemi et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Bis(NHC)-Palladium(II) Complex-Catalyzed Dioxygenation of Alkenes

(2010) Wenfeng Wang et al.   ORGANOMETALLICS

N-Heterocyclic carbene-stabilized gold nanoparticles and their assembly into 3D superlattices

(2009) Joan Vignolle et al.   CHEMICAL COMMUNICATIONS

Complexes with Poly(N-heterocyclic carbene) Ligands: Structural Features and Catalytic Applications

(2009) Macarena Poyatos et al.   CHEMICAL REVIEWS

N-Heterocyclic Carbenes in Late Transition Metal Catalysis

(2009) Silvia Díez-González et al.   CHEMICAL REVIEWS

Beyond ConventionalN-Heterocyclic Carbenes: Abnormal, Remote, and Other Classes of NHC Ligands with Reduced Heteroatom Stabilization

(2009) Oliver Schuster et al.   CHEMICAL REVIEWS

Diverse Chemical Applications of N-Heterocyclic Carbenes

(2009)   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene coated metal nanoparticles

(2009) Eleanor C. Hurst et al.   NEW JOURNAL OF CHEMISTRY

Carbenes: Synthesis, properties, and organometallic chemistry

(2008) Pierre de Frémont et al.   COORDINATION CHEMISTRY REVIEWS

Au(i)-benzimidazole/imidazole complexes. Liquid crystals and nanomaterials

(2008) S. J. Hsu et al.   DALTON TRANSACTIONS

A Weak Donor, Planar Chelating Bitriazole N-Heterocyclic Carbene Ligand for Ruthenium(II), Palladium(II), and Rhodium

(2008) Macarena Poyatos et al.   ORGANOMETALLICS