Cooperation and crosstalk in axon guidance cue integration: Additivity, synergy, and fine-tuning in combinatorial signaling

Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target

(2016) Alemji A. Taku et al.   DEVELOPMENT

Exosomes mediate cell contact–independent ephrin-Eph signaling during axon guidance

(2016) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Equivalent Activities of Repulsive Axon Guidance Receptors

(2016) H. Long et al.   JOURNAL OF NEUROSCIENCE

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

(2016) Edmund R Hollis et al.   NATURE NEUROSCIENCE

Integration of Innate Immune Signaling

(2016) Christoph A. Thaiss et al.   TRENDS IN IMMUNOLOGY

A mathematical model explains saturating axon guidance responses to molecular gradients

(2016) Huyen Nguyen et al.   eLife

Applications of CRISPR–Cas systems in neuroscience

(2015) Matthias Heidenreich et al.   NATURE REVIEWS NEUROSCIENCE

Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons

(2015) Isabelle Dupin et al.   Neural Development

The Intracellular Domain of the Frazzled/DCC Receptor Is a Transcription Factor Required for Commissural Axon Guidance

(2015) Alexandra Neuhaus-Follini et al.   NEURON

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2

(2015) A. Jaworski et al.   SCIENCE

Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex

(2015) Yohei Shinmyo et al.   Nature Communications

A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist

(2015) Xuefan Gao et al.   Cell Reports

Glypican Is a Modulator of Netrin-Mediated Axon Guidance

(2015) Cassandra R. Blanchette et al.   PLOS BIOLOGY

Integration of Shallow Gradients of Shh and Netrin-1 Guides Commissural Axons

(2015) Tyler F. W. Sloan et al.   PLOS BIOLOGY

SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) Function Interdependently to Promote Axon Guidance by Regulating the MIG-2 GTPase

(2015) Yan Xu et al.   PLoS Genetics

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

(2015) Sebastian Poliak et al.   eLife

Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

(2015) Timothy A Evans et al.   eLife

Crossing the embryonic midline: molecular mechanisms regulating axon responsiveness at an intermediate target

(2015) Alexandra Neuhaus-Follini et al.   Wiley Interdisciplinary Reviews-Developmental Biology

FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons

(2014) Eduardo Leyva-Díaz et al.   CURRENT BIOLOGY

Celsr3 is required in motor neurons to steer their axons in the hindlimb

(2014) Guoliang Chai et al.   NATURE NEUROSCIENCE

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments

(2014) Céline Delloye-Bourgeois et al.   NATURE NEUROSCIENCE

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

(2014) Pavol Zelina et al.   NEURON

FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development

(2014) Elena Seiradake et al.   NEURON

Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor

(2014) Patrick C. G. Haddick et al.   PLoS One

EVA-1 Functions as an UNC-40 Co-receptor to Enhance Attraction to the MADD-4 Guidance Cue in Caenorhabditis elegans

(2014) Kevin Ka Ming Chan et al.   PLoS Genetics

Netrins and Wnts Function Redundantly to Regulate Antero-Posterior and Dorso-Ventral Guidance in C. elegans

(2014) Naomi Levy-Strumpf et al.   PLoS Genetics

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Integration of guidance cues: parallel signaling and crosstalk

(2013) Irina Dudanova et al.   TRENDS IN NEUROSCIENCES

DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain

(2013) Katherine E. Horn et al.   Cell Reports

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

(2013) Zhong L Hua et al.   eLife

Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals

(2012) Dario Bonanomi et al.   CELL

Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling

(2012) Tony Oosterveen et al.   DEVELOPMENTAL CELL

Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth

(2012) Erik Mire et al.   NATURE NEUROSCIENCE

Calcium and cAMP Levels Interact to Determine Attraction versus Repulsion in Axon Guidance

(2012) Elizabeth M. Forbes et al.   NEURON

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

(2012) N. Perrimon et al.   Cold Spring Harbor Perspectives in Biology

Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography

(2011) Franck Bielle et al.   CURRENT BIOLOGY

Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones

(2011) O. Stettler et al.   DEVELOPMENT

MADD-4 Is a Secreted Cue Required for Midline-Oriented Guidance in Caenorhabditis elegans

(2011) Ashwin Seetharaman et al.   DEVELOPMENTAL CELL

Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCC

(2011) G. Ahmed et al.   JOURNAL OF NEUROSCIENCE

Second messengers and membrane trafficking direct and organize growth cone steering

(2011) Takuro Tojima et al.   NATURE REVIEWS NEUROSCIENCE

VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1

(2011) Carmen Ruiz de Almodovar et al.   NEURON

VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm

(2011) Lynda Erskine et al.   NEURON

Eph and ephrin signaling: Lessons learned from spinal motor neurons

(2011) Tzu-Jen Kao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

FAK

(2011) Mariola R. Chacón et al.   Cell Adhesion & Migration

Sonic Hedgehog Guides Post-Crossing Commissural Axons Both Directly and Indirectly by Regulating Wnt Activity

(2010) E. Domanitskaya et al.   JOURNAL OF NEUROSCIENCE

When pathways collide: collaboration and connivance among signalling proteins in development

(2010) Helen McNeill et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signal integration through blending, bolstering and bifurcating of intracellular information

(2010) Catherine T Pawson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance

(2010) E. W. Dent et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms and Molecules of Neuronal Wiring: A Primer

(2010) A. L. Kolodkin et al.   Cold Spring Harbor Perspectives in Biology

Visual Map Development: Bidirectional Signaling, Bifunctional Guidance Molecules, and Competition

(2010) D. A. Feldheim et al.   Cold Spring Harbor Perspectives in Biology

Src Family Kinases Are Required for Limb Trajectory Selection by Spinal Motor Axons

(2009) T.-J. Kao et al.   JOURNAL OF NEUROSCIENCE

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS

(2009) Tracy S. Tran et al.   NATURE

Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo

(2009) Andrea Wizenmann et al.   NEURON

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Draxin, a Repulsive Guidance Protein for Spinal Cord and Forebrain Commissures

(2009) S. M. Islam et al.   SCIENCE

Retinal Axon Growth at the Optic Chiasm: To Cross or Not to Cross

(2008) Timothy J. Petros et al.   Annual Review of Neuroscience

A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5

(2008) Xin Yue et al.   Developmental Neurobiology

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

(2008) Zhe Chen et al.   NEURON

Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb

(2008) Victor Luria et al.   NEURON