Article
Environmental Sciences
Fahriye Zemheri-Navruz, Sinan Ince, Damla Arslan-Acaroz, Ulas Acaroz, Hasan Huseyin Demirel, Ezgi Nur Demirkapi
Summary: This study aimed to determine the protective effect of Res against Pyra-induced lipid peroxidation, oxidative stress, and DNA damage in rats. Researchers found that Res administrations in a dose-dependent manner improved Pyra-induced lipid peroxidation, oxidative and DNA damages, gene expressions, and histopathological changes in the liver and kidney.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Sitong Yao, Wei Wei, Rui Cao, Lin Lu, Shijin Liang, Mingjun Xiong, Chen Zhang, Xiaohuan Liang, Yongjiang Ma
Summary: This study investigated the effects of the mycotoxin zearalenone on decidualization of human endometrial stromal cells, revealing that ZEA inhibits the decidualization process through nuclear translocation of ER alpha. However, this inhibitory effect can be attenuated by an estrogen receptor antagonist, and resveratrol administration can restore impaired decidualization by inducing the antioxidative gene GPX3.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Nese B. Turkmen, Hande Yuce, Yasemin Sahin, Asli C. Taslidere, Dilan A. Ozek, Songul Unuvar, Osman Ciftci
Summary: The present study investigates the protective effects of resveratrol on brain and liver tissues in rats with pembrolizumab-induced toxicity. Resveratrol treatment reduced the levels of thiobarbituric acid reactive substance and increased the activities of glutathione peroxidase, catalase, and superoxide dismutase, as well as the levels of glutathione. It also decreased the expression of caspase-3 protein and histopathological changes in the liver and brain tissues.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Jian Lu, Yun Yang, Lianhua Zhu, Meng Li, Wenping Xu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang
Summary: Natural pyrethrins induce oxidative stress, DNA damage and liver toxicity in both human HepG2 cells and zebrafish. The observed chronic toxicity may lead to irreversible DNA damage and severe toxic effects on cells. In conclusion, hepatotoxicity of natural pyrethrins poses a risk to human health by causing liver degeneration and steatosis.
Article
Biochemistry & Molecular Biology
Ilknur Bingul, Vakur Olgac, Seldag Bekpinar, Mujdat Uysal
Summary: Resveratrol effectively reduced oxidative stress and hepatotoxicity induced by cyclosporine A in rats, demonstrating potential as a treatment for liver injury caused by immunosuppressive agents.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Fisheries
Guanghua Xiong, Hongmei Hu, Haiyan Zhang, June Zhang, Zigang Cao, Huiqiang Lu, Xinjun Liao
Summary: In this study, the hepatotoxic and immunotoxic effects of Cyhalofop-butyl (CyB) exposure in zebrafish embryos were systematically investigated. CyB exposure led to decreased survival rate and developmental abnormalities in zebrafish. Additionally, CyB exposure resulted in significant changes in cellular and genetic levels, including oxidation-reduction, lipid metabolism, and immune inflammation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Mahrous A. Ibrahim, Athar M. Khalifa, Alaa A. Mohamed, Rania A. Galhom, Horeya E. Korayem, Noha M. Abd El-Fadeal, Ahmed Abd-Eltawab Tammam, Mohamed Mansour Khalifa, Osama S. Elserafy, Rehab Abdel-Karim
Summary: The pretreatment with olive leaf extract, bone-marrow-derived mesenchymal stem cells, and their conditioned media has a beneficial effect in ameliorating cisplatin-induced liver and kidney damage, reducing oxidative stress, inflammation, and apoptosis.
Article
Biochemistry & Molecular Biology
Muhammed Atamanalp, Hasan Turkez, Asli cilingir Yeltekin, Fatma Betuel Ozgeris, Arzu Ucar, Ozge caglar, Veysel Parlak, Sena Oner, Gonca Alak
Summary: The compound acrylamide (AA) is widely used in industries such as paper, dyes, and plastics, but its water solubility suggests it could pose environmental problems. AA has been found to be neurotoxic, immunotoxic, reproductive toxic, and carcinogenic in animals. This study investigated the potential of boron compounds, such as borax (BX), to ameliorate AA-induced toxicities in rainbow trout. The results showed that AA exposure led to oxidative stress and DNA damage in both blood and liver tissues of the fish. However, co-exposure of BX with AA also elicited oxidative stress and cell death. Overall, BX was suggested as a useful and effective natural agent for preventing and treating AA toxicity in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenjing Dong, Erqun Song, Yang Song
Summary: The study found that co-treatment of LPS/D-GalN exhibited genotoxic effects on liver and brain cells in mice, but not on sperm and bone marrow cells. This indicates the potential genotoxicity of LPS/D-GalN administered together, suggesting it as an in vivo experimental model for genotoxic studies.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Changqing Zhang, Chenqinyao Li, Kechun Liu, Yun Zhang
Summary: Zearalenone, a mycotoxin found in crops and cereals, poses serious health risks to humans and animals. This study used a zebrafish model to comprehensively evaluate the hepatotoxic effects of zearalenone and investigate its molecular mechanism. The results revealed that zearalenone exposure caused liver injury, disrupted oxidation and reduction processes, increased lipid peroxidation, and affected glucuronidation and amino acid metabolism.
Review
Biochemistry & Molecular Biology
Iwona Bukowska-Osko, Dorota Sulejczak, Katarzyna Kaczynska, Patrycja Kleczkowska, Karol Kramkowski, Marta Popiel, Ewa Wietrak, Pawel Kowalczyk
Summary: Structural abnormalities can cause DNA modifications, leading to various diseases including cancer. Cells defend and repair damaged genetic material through lactoferrin, an endogenous protein with antibacterial, antiviral, antifungal, and anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy
Summary: This study found that Tris (2-ethylhexyl) phosphate (TEHP) has cytotoxic and genotoxic effects on HepG2 cells, possibly through inducing oxidative stress, causing mitochondrial dysfunction, and leading to DNA damage and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yuyang Peng, Min Li, Yong Huang, Bo Cheng, Zigang Cao, Xinjun Liao, Guanghua Xiong, Fasheng Liu, Chengyu Hu, Huiqiang Lu
Summary: Exposure to bifenazate has immunotoxicity and oxidative stress effects on zebrafish larvae, affecting growth and development, decreasing immune cells, and inhibiting antioxidant activity. Astaxanthin can effectively alleviate this developmental toxicity.
Article
Biochemistry & Molecular Biology
Consiglia Longobardi, Sara Damiano, Emanuela Andretta, Francesco Prisco, Valeria Russo, Francesco Pagnini, Salvatore Florio, Roberto Ciarcia
Summary: The study demonstrated that curcumin has cytoprotective and antioxidant activities against OTA-induced nephrotoxicity and hepatotoxicity in rats by regulating inflammation, reducing nitric oxide levels, and decreasing oxidative DNA damage.
Article
Multidisciplinary Sciences
Dalia Fouad, Esraa Shuker, Manal Farhood
Summary: This study investigated the protective effects of boldine, a natural antioxidant, against methylprednisolone-induced renal toxicity. The results showed that oral administration of boldine had antioxidant, anti-apoptotic, and anti-inflammatory effects, and improved renal damage caused by methylprednisolone.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Promy Virk, Manal A. Awad, Sarah Saleh Abdu-llah Alsaif, Awatif A. Hendi, Mai Elobeid, Khalid Ortashi, Rabia Qindeel, Manal F. El-Khadragy, Hany M. Yehia, Mohamed Ferkry Serag El-din, Hatem Ali Salama
Summary: The present study successfully synthesized stable 'green' nanoparticles of Moringa oleifera leaf extract and characterized their properties. The nanoparticles had an average particle size of 141.6 nm and a polydispersity index (PDI) of 0.32. They exhibited strong absorbance at 664 nm, indicating the presence of chlorophyll. The nanoparticles showed potent antioxidant activity and a higher phenolic/flavonoid content compared to the bulk leaf extract. Furthermore, they demonstrated greater therapeutic efficacy in anti-diabetic and cytotoxicity assays on human cancer cell lines.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Munira Abdullah Rashed Alqahtani, Promy Virk, Dalia Fouad
Summary: This study assessed the ameliorative potential of Spirulina against DEHP-induced toxicity. The findings revealed that Spirulina effectively reversed the adverse effects of DEHP, providing a nutritional intervention to combat environmental exposure to plasticizers.
ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY
(2023)
Article
Environmental Sciences
Linzhen Li, Yangli Tu, Xiangjie Dai, Shengjia Xiao, Zhiyi Tang, Yi Wu, Dalia Fouad, Farid Shokry Ataya, Khalid Mehmood, Kun Li
Summary: Abrus cantoniensis Hance has the potential to relieve CCl4-induced liver damage by reducing inflammation, enhancing antioxidant capacity, and regulating intestinal microbiota.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Manal Qayyadh Alanazi, Promy Virk, Seham Soliman Alterary, Manal Awad, Zubair Ahmad, Abdulrehman M. Albadri, KalidM. Ortashi, Mohieldeen Mahgoub A. Ahmed, Mohamed Ismail Ali Yousef, Mai Elobeid, Ebtesam Abdullah Al-Qahtani
Summary: The aim of this study was to qualitatively assess the presence of microplastics (MPs) in the sewage effluent of a local treatment plant in Riyadh City, Saudi Arabia. The researchers used zinc oxide nanoparticles (ZnONPs) and UV light-induced photocatalysis to degrade the MPs. The study also evaluated the toxicological effects of the MPs on Nile tilapia, observing significant responses in various endpoints.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
I. Khan, S. Masood, S. Ashraf, H. F. Rehman, A. Ullah, F. S. Ataya, G. e. -s. Batiha, R. Taj, A. M. Elgazzar, S. Din
Summary: This study evaluated the effects of dietary selenium nanoparticles (SeNP) coated with chitosan (CS) on the immune system of broilers. The results showed that supplementation with SeNP-C-CS improved the morphology of immune organs, redox status, and humoral immune responses in broilers.
JOURNAL OF APPLIED POULTRY RESEARCH
(2023)
Article
Crystallography
Manal A. A. Awad, Meznah M. M. Alanazi, Awatif A. Hendi, Promy Virk, Albandari W. W. Alrowaily, Taghreed Bahlool, Fatimah Al-Abbas, Fatma Aouaini, Khalid M. O. Ortashi
Summary: This study reports a novel method of fabricating probiotic nanowhiskers using pure cheese as a source of probiotics, without the use of metal/chemical surfactants. Extensive characterization was conducted, including FTIR spectroscopy, X-ray diffraction, particle size measurements, and transmission electron microscopy. The results showed that the cheese nanowhiskers demonstrated potential as a safe and efficacious dietary intervention for heavy metal toxicity and oxidative damage.
Article
Engineering, Chemical
Manal A. Awad, Promy Virk, Awatif A. Hendi, Khalid Mustafa Ortashi, Najla Almasoud, Taghrid S. Alomar
Summary: As the human population grows, the demand for clean water is increasing. This study synthesized AgNPs using an aqueous extract of Trigonella foenum-graecum seeds. The AgNPs showed potential wastewater remediation efficacy, antimicrobial activity, and photodegradative activity. Therefore, biogenically synthesized AgNPs offer a prospective potential for use in wastewater remediation strategies.
Article
Microbiology
Muhammad Sohail Sajid, Asif Iqbal, Hafiz Muhammad Rizwan, Asma Kausar, Urfa Bin Tahir, Muhammad Younus, Mahvish Maqbool, Rao Muhammad Siddique, Dalia Fouad, Farid Shokry Ataya
Summary: The study focused on the risk of tick-borne theileriosis in populations of buffalos and cattle in Punjab, Pakistan. The research found that the tick species Hyalomma anatolicum, Rhipicephalus (Boophilus) microplus, and R. sanguineus had higher infection rates, while ticks collected from riverine environments and from cattle had higher prevalence. Age and sex were also found to be significantly associated with Theileria infection in large ruminants.
Article
Biotechnology & Applied Microbiology
Farah Naz Talpur, Ahsanullah Unar, Sana Kanwal Bhatti, Laila Alsawalha, Dalia Fouad, Humaira Bashir, Hassan Imran Afridi, Farid Shokry Ataya, Ohoud A. Jefri, Muhammad Sohail Bashir
Summary: Imidacloprid, a widely used toxic pesticide in agriculture, can cause serious health problems. This study highlights the degradation efficiency of Bacillus sp. on imidacloprid, with Bacillus cereus showing the highest degradation ability. By optimizing experimental variables (pH, imidacloprid concentration, and agitation time) using Box-Behnken factorial design and analysis of variance (ANOVA), a 92% biodegradation of imidacloprid was achieved within 11 days aerobically at an initial substrate concentration of 0.03 mM and pH 7. The subsequent metabolites identified were 5-hydroxy imidacloprid, imidacloprid-guanidine, and 6-chloronicotinic acid.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Malak Abdullah Al-Qahtani, Promy Virk, Manal Awad, Mai Elobeid, Khawlah Sultan Alotaibi
Summary: This study evaluated the protective effect of citrus flavanone, naringin, and its nanoformulation against di(2-ethylhexyl)phthalate (DEHP) toxicity in albino rats. Nanoparticles of naringin were synthesized and characterized, and their therapeutic utility in alleviating DEHP-induced oxidative stress and inflammatory response was demonstrated. The results indicate that naringin nanoparticles have potential in nutraceutical therapeutics with high environmental credentials.
GREEN PROCESSING AND SYNTHESIS
(2023)
Article
Chemistry, Multidisciplinary
Promy Virk, Manal A. Awad, Meznah M. Alanazi, Awatif A. Hendi, Mai Elobeid, Khalid M. Ortashi, Albandari W. Alrowaily, Taghreed Bahlool, Fatma Aouaini
Summary: In recent decades, nanotechnology has shown promising prospects in biomedicine and has been proven to enhance therapeutics by facilitating drug delivery. This study combines nanoscience with clean technology by fabricating nature-friendly nanoparticles using Indian mustard seeds. The nanoparticles were characterized through various techniques and were found to be crystalline in nature with an average size of 205.5 nm. The therapeutic efficacy of the green nanoparticles was evaluated on human cancer cell lines and was found to be more effective than the bulk seeds. Overall, these mustard seed nanoparticles have potential nutraceutical properties due to their green synthesis.
GREEN PROCESSING AND SYNTHESIS
(2023)
Article
Oncology
Abubakar Awwal Yusuf, Bashir Lawal, Uchenna Blessing Alozieuwa, Amos S. Onikanni, Halimat Yusuf Lukman, Adewale O. Fadaka, Femi Olawale, Obinna Osuji, Saidu Sani, Mayowa Solomon Owolabi, Abdulsalam H. Adewuyi, Deborah H. Yusuf, Gaber El-Saber Batiha, Farid S. Ataya, Dalia Fouad
Summary: This study evaluated the ameliorative effects of Azanza garckeana on diabetes-induced dyslipidemia, hepatopathy, and nephropathy. The results showed that the crude extract of A. garckeana had a dose-dependent hypoglycemic effect and improved the weight and lipid profiles in diabetic rats. The ethyl acetate fraction of this plant exhibited remarkable protective effects against diabetes-induced complications. The characterization of the active fraction identified the presence of phenolic and flavonoid compounds that may be responsible for its bioactivity.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Muddasir Basheer, Aashaq Hussain Bhat, Younis Ahmad Hajam, Gaber El-Saber Batiha, Farid S. Ataya, Dalia Fouad, Seema Rai
Summary: The study found that melatonin treatment significantly improved PCOS symptoms in rats, including changes in body weight, hormone levels, enzyme activity, and ovarian histopathological features. These results suggest that exogenous melatonin may be a valuable treatment for PCOS in female rats.
Article
Veterinary Sciences
Wenting Zhang, Yuxuan Li, Xuan Ye, Zhijian Ma, Xiuhua Wei, Jiaqiang Pan, Zhaoxin Tang, Lianmei Hu, Ying Li, Dalia Fouad, Farid Shokry Ataya
Summary: Pulmonary hypertension syndrome (PHS) is a poultry disease that causes economic losses in broilers, and its mechanism is not fully understood. This study found that mitochondrial fusion in the liver was diminished and mitochondrial fission was enhanced in PHS broilers.
PAKISTAN VETERINARY JOURNAL
(2023)
