Article
Physiology
Di-Xian Wang, Xu-Dong Zhu, Xiao-Ru Ma, Li-Bin Wang, Zhao-Jun Dong, Rong-Rong Lin, Yi-Na Cao, Jing-Wei Zhao
Summary: The study confirmed the crucial role of GDF11 in maintaining telomere length in cells, and demonstrated that the lack of GDF11 leads to telomere shortening and reduced telomerase activity, indicating the significant impact of GDF11 on the cell cycle.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Nirodhi Namika Dasanayaka, Nirmala Dushyanthi Sirisena, Nilakshi Samaranayake
Summary: This study found associations between long-term meditation and telomere length, expression of hTERT and hTR genes, and methylation of the promoter region of hTERT gene. Meditators had longer telomeres, higher expression of hTERT and hTR genes, and lower methylation level of the promoter region of hTERT gene compared to non-meditators. These findings suggest that meditation as a lifestyle practice has multi-level beneficial effects on telomere dynamics, potentially promoting healthy aging.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
A. Yun, Shangli Shi, Shoujiang Sun, Yuanyuan Jing, Zili Li, Xiaoyan Zhang, Xiaolong Li, Fang Wu
Summary: In this study, we conducted a longitudinal analysis of telomerase activity and relative telomere length in different varieties of alfalfa. We found significant differences in telomerase activity and relative telomere length between plants of different ages and varieties. The relative telomere length is influenced by genetic variation and age, with age exerting a greater effect.
Article
Substance Abuse
Fatemeh Zahra Darvishi, Mostafa Saadat
Summary: This study found that the mRNA levels of hTERT and TERF2 in cells treated with morphine decrease with increasing exposure time, but this alteration is reversible when morphine is removed from the culture medium. Additionally, there was no reduction in the relative expression of hTERT and TERF2 in cells co-treated with N-acetyl cysteine (NAC) and morphine.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Sport Sciences
Marlies Schellnegger, Alvin C. Lin, Niels Hammer, Lars-Peter Kamolz
Summary: Healthy life expectancy lags behind overall life expectancy, and increasing overall fitness through physical activity can attenuate the impact of aging. Telomere biology is a key factor in understanding the relationship between exercise and aging, but there is still uncertainty regarding the optimal intensity, duration, and type of physical activity.
SPORTS MEDICINE-OPEN
(2022)
Article
Chemistry, Physical
Nihal Inandiklioglu, Ayca Tas, Tugba Agbektas, Zuhal Tuncbilek, Kayode Yomi Raheem, Gulcihan Cinar, Yavuz Silig
Summary: This study aimed to determine the anticancer activity of the chemotherapeutic agent docetaxel in neuroblastoma cell line (SH-SY5Y) and investigate its effect on hTERT gene expression level and telomere length. The results showed that docetaxel reduced the expression level of the hTERT gene in SH-SY5Y cells and significantly shortened telomere length. Molecular docking analysis confirmed the interaction between docetaxel and the active site of telomerase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Sandor Pentek, Akos Varnagy, Balint Farkas, Peter Mauchart, Krisztina Godony, Timea Varjas, Tamas Koszegi, Peter Kaltenecker, Rita Jakabfi-Csepregi, Kalman Kovacs, Jozsef Bodis, Endre Sulyok
Summary: This study aimed to investigate the relationship between telomere length, telomerase activity, and oxidative DNA damage in IVF patients. The study found that telomere lengths were similar in granulosa cells and follicular fluid, but telomerase activity was significantly reduced and 8-OHdG levels were significantly elevated in follicular fluid. Additionally, high levels of 8-OHdG were associated with negative outcomes in IVF success and clinical pregnancies.
Article
Biotechnology & Applied Microbiology
Chenjing Ma, Xian Li, Weifeng Ding, Xin Zhang, Hang Chen, Ying Feng
Summary: In this study, the effects of introducing exogenous hTERT on Periplaneta americana cells were investigated. It was found that hTERT expression promoted cell growth and extended cell lifespan by increasing telomerase activity and elongating telomeres. This suggests that introducing hTERT into insect cells could be an efficient method to establish certain insect cell lines.
Review
Oncology
Peter Lansdorp
Summary: The number of telomere repeats varies greatly between chromosomes, cells, and species. Loss of telomere repeats limits cell proliferation and contributes to aging, but the mechanisms behind these processes are still not fully understood. Further research is needed to investigate the role of factors such as damaged telomeric DNA, replication errors, chromatin structure, and secondary DNA structures in telomere dynamics in different cell types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Stina George Fernandes, Rebecca Dsouza, Ekta Khattar
Summary: The external environment influences cellular physiological processes and genome stability, particularly impacting telomeres. Telomeres protect genome integrity by preventing DNA damage response and end-to-end fusions. External factors like oxidative stress and inflammation impact telomere stability.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biology
Megan L. Power, Roger D. Ransome, Sebastien Riquier, Luke Romaine, Gareth Jones, Emma C. Teeling
Summary: This study measured the relative telomere length in long-lived bats over three winters and found variations in telomeres during hibernation. These findings highlight the beneficial effects of hibernation on telomeres and potential consequences of changing climatic conditions for bats.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Esther Garcia-Esquinas, Rosario Ortola, Antonio Buno, Pablo Olmedo, Fernando Gil, Jose R. Banegas, Beatriz Perez-Gomez, Ana Navas-Acien, Fernando Rodriguez-Artalejo
Summary: This study examined the relationship between blood cadmium levels and serum GDF-15 concentrations in community-dwelling older adults. The results showed a dose-response association between cadmium levels and GDF-15, suggesting that cadmium exposure may be related to enhanced GDF-15 expression.
ENVIRONMENTAL RESEARCH
(2022)
Article
Neurosciences
Juan Luis Sanchez-Gonzalez, Juan Luis Sanchez-Rodriguez, Javier Martin-Vallejo, Abel Martel-Martel, Rogelio Gonzalez-Sarmiento
Summary: The study shows that a 6-month physical exercise program can significantly improve cognitive functions and telomere length in adults over 65 years of age.
Article
Biochemistry & Molecular Biology
Axel Karow, Monika Haubitz, Elisabeth Oppliger Leibundgut, Ingrid Helsen, Nicole Preising, Daniela Steiner, Tobias M. Dantonello, Roland A. Ammann, Jochen Roessler, Mutlu Kartal-Kaess, Alexander Roeth, Gabriela M. Baerlocher
Summary: The study found significant differences in telomere length and telomerase activity in lymphoblasts of patients with acute lymphoblastic leukemia. High-risk pediatric ALL patients had higher telomerase activity, and the telomerase inhibitor imetelstat showed significant dose-dependent apoptosis of B-ALL cells. Telomere length and telomerase activity may serve as complementary markers for identifying high-risk ALL patients, and telomerase inhibitors like imetelstat could enhance standard ALL treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A. Class, Kelly A. Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A. Bertuch, Courtney D. DiNardo, Guillermo Garcia-Manero, Neal S. Young, Karen Dwyer, Simona Colla
Summary: The study reveals that telomere attrition leads hematopoietic stem cells towards differentiation into megakaryocytic lineage through upregulated innate immune signaling response, ultimately compromising their self-renewal capabilities and leading to depletion. Targeting the IFI16 signaling axis could potentially prevent functional decline of hematopoietic stem cells under conditions affecting telomere maintenance.
NATURE COMMUNICATIONS
(2021)