Main-chain water-soluble polyphosphoesters: Multi-functional polymers as degradable PEG-alternatives for biomedical applications

Antibodies against polyethylene glycol in human blood: A literature review

(2020) Lu Hong et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

(2020) Thai Thanh Hoang Thi et al.   Polymers

Insight into Protein–Polymer Conjugate Relaxation Dynamics: The Importance of Polymer Grafting

(2020) Daniela Russo et al.   MACROMOLECULAR BIOSCIENCE

Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications

(2020) Paul Strasser et al.   MOLECULES

Water-soluble and degradable polyphosphorodiamidates via thiol-ene polyaddition

(2020) Mark Steinmann et al.   POLYMER DEGRADATION AND STABILITY

Polyphosphoester surfactants as general stealth coatings for polymeric nanocarriers

(2020) Kristin N. Bauer et al.   Acta Biomaterialia

Poly(methyl ethylene phosphate) hydrogels: Degradable and cell-repellent alternatives to PEG-hydrogels

(2020) Hisaschi T. Tee et al.   EUROPEAN POLYMER JOURNAL

Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa

(2019) Qingquan Chen et al.   MOLECULAR PHARMACEUTICS

Protein–Polymer Dynamics as Affected by Polymer Coating and Interactions

(2019) D. Russo et al.   LANGMUIR

Multifunctional Polymeric Prodrug with Simultaneous Conjugating Camptothecin and Doxorubicin for pH/Reduction Dual-Responsive Drug Delivery

(2019) Shuxiang Dong et al.   ACS Applied Materials & Interfaces

Protein PEPylation: A New Paradigm of Protein–Polymer Conjugation

(2019) Yingqin Hou et al.   BIOCONJUGATE CHEMISTRY

Effect of Polymer Chain Density on Protein–Polymer Conjugate Conformation

(2019) Daniela Russo et al.   BIOMACROMOLECULES

DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by a Nucleobase

(2019) Wenliang Wang et al.   BIOMACROMOLECULES

Mechanistic study of transesterification in TBD-catalyzed ring-opening polymerization of methyl ethylene phosphate

(2019) Ilya E. Nifant'ev et al.   EUROPEAN POLYMER JOURNAL

Design of Degradable Polyphosphoester Networks with Tailor-Made Stiffness and Hydrophilicity as Scaffolds for Tissue Engineering

(2019) Raphaël Riva et al.   BIOMACROMOLECULES

Ultrafast hydrolytic degradation of 2,3-dihydroxypropyl functionalized poly(ethylene phosphates)

(2019) Maxim A. Kosarev et al.   MENDELEEV COMMUNICATIONS

Coordination Ring-Opening Polymerization of Cyclic Esters: A Critical Overview of DFT Modeling and Visualization of the Reaction Mechanisms

(2019) Ilya Nifant’ev et al.   MOLECULES

Noncovalent Targeting of Nanocarriers to Immune Cells with Polyphosphoester‐Based Surfactants in Human Blood Plasma

(2019) Johanna Simon et al.   Advanced Science

A fully degradable and photocrosslinked polysaccharide-polyphosphate hydrogel for tissue engineering

(2019) Ying Hao et al.   CARBOHYDRATE POLYMERS

In Situ Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique

(2019) Richen Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DFT Modeling of Organocatalytic Ring-Opening Polymerization of Cyclic Esters: A Crucial Role of Proton Exchange and Hydrogen Bonding

(2019) Ilya Nifant’ev et al.   Polymers

From Synthesis to Characterization of Site-Selective PEGylated Proteins

(2019) Lisandra Herrera Belén et al.   Frontiers in Pharmacology

Folate-Conjugated Polyphosphoester with Reversible Cross-Linkage and Reduction Sensitivity for Drug Delivery

(2018) Youwen Cao et al.   ACS Applied Materials & Interfaces

Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers

(2018) Johanna Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Firefighting-How Modern Phosphorus Chemistry Can Help Solve the Challenge of Flame Retardancy

(2018) Maria M. Velencoso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Degradable Hyperbranched Polyphosphoester Micellar Nanomedicines for NIR Imaging-Guided Chemo-Photothermal Therapy of Drug-Resistant Cancers

(2018) Mengqun Yao et al.   BIOMACROMOLECULES

Development of Fully Degradable Phosphonium-Functionalized Amphiphilic Diblock Copolymers for Nucleic Acids Delivery

(2018) Yannick P. Borguet et al.   BIOMACROMOLECULES

Polymerizing Phostones: A Fast Way to In-Chain Poly(phosphonate)s with Adjustable Hydrophilicity

(2018) Kristin N. Bauer et al.   MACROMOLECULES

Acid-Triggered Polymer Backbone Degradation and Disassembly to Achieve Release of Camptothecin from Functional Polyphosphoramidate Nanoparticles

(2018) Hai Wang et al.   ACS Macro Letters

A biodegradable polyphosphoester-functionalized poly(disulfide)s nanocarrier for reduction-triggered intracellular drug delivery

(2018) Pengfei Ju et al.   Journal of Materials Chemistry B

Dual-Responsive Polyphosphoester-Doxorubicin Prodrug Containing a Diselenide Bond: Synthesis, Characterization, and Drug Delivery

(2018) Guoqing Ma et al.   ACS Biomaterials-Science & Engineering

Dual-Responsive Polyphosphoester-Doxorubicin Prodrug Containing a Diselenide Bond: Synthesis, Characterization, and Drug Delivery

(2018) Guoqing Ma et al.   ACS Biomaterials Science & Engineering

Functional biodegradable polymers via ring-opening polymerization of monomers without protective groups

(2018) Greta Becker et al.   CHEMICAL SOCIETY REVIEWS

PPEylation of proteins: Synthesis, activity, and stability of myoglobin-polyphosphoester conjugates

(2018) Chiara Pelosi et al.   EUROPEAN POLYMER JOURNAL

Mechanistic study on the hydrolytic degradation of polyphosphates

(2018) Kristin N. Bauer et al.   EUROPEAN POLYMER JOURNAL

Stimuli-Responsive Phosphorus-Based Polymers

(2018) Ian Teasdale   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Functional, Degradable Zwitterionic Polyphosphoesters as Biocompatible Coating Materials for Metal Nanostructures

(2018) Richen Li et al.   LANGMUIR

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Thermodynamic stability of myoglobin-poly(ethylene glycol) bioconjugates: A calorimetric study

(2018) Chiara Pelosi et al.   THERMOCHIMICA ACTA

Mechanistic Insights of BHT-Mg-Catalyzed Ethylene Phosphate’s Coordination Ring-Opening Polymerization: DFT Modeling and Experimental Data

(2018) Ilya Nifant’ev et al.   Polymers

Selective cleavage of the polyphosphoester in crosslinked copper based nanogels: enhanced antibacterial performance through controlled release of copper

(2017) Nagarajan Padmavathy et al.   Nanoscale

Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

(2017) Fuwu Zhang et al.   Nanoscale

Controlled ring-opening polymerisation of cyclic phosphates, phosphonates and phosphoramidates catalysed by heteroleptic BHT-alkoxy magnesium complexes

(2017) I. E. Nifant'ev et al.   Polymer Chemistry

Main-chain poly(phosphoester)s: History, syntheses, degradation, bio-and flame-retardant applications

(2017) Kristin N. Bauer et al.   PROGRESS IN POLYMER SCIENCE

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA

(2017) Hadeel Elzeny et al.   Drug Design Development and Therapy

Cytotoxicity study of polyethylene glycol derivatives

(2017) Guoqiang Liu et al.   RSC Advances

Polyphosphoramidates That Undergo Acid-Triggered Backbone Degradation

(2017) Hai Wang et al.   ACS Macro Letters

Dual-responsive core-crosslinked polyphosphoester-based nanoparticles for pH/redox-triggered anticancer drug delivery

(2017) Yue Sun et al.   Journal of Materials Chemistry B

Camptothecin-based nanodrug delivery systems

(2017) Wen Yan et al.   Cancer Biology & Medicine

In vitro blood cell viability profiling of polymers used in molecular assembly

(2017) Hyejoong Jeong et al.   Scientific Reports

Degradable Polyphosphoester-Protein Conjugates: “PPEylation” of Proteins

(2016) Tobias Steinbach et al.   BIOMACROMOLECULES

Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer

(2016) S R Rao et al.   BRITISH JOURNAL OF CANCER

Poly(phosphorodiamidate)s by Olefin Metathesis Polymerization with Precise Degradation

(2016) Mark Steinmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice

(2016) Sabine M. Poppenborg et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

(2016) Kouichi Shiraishi et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Polyphosphoesters: New Trends in Synthesis and Drug Delivery Applications

(2016) Zeynep Ergul Yilmaz et al.   MACROMOLECULAR BIOSCIENCE

Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates

(2016) Tobias Steinbach et al.   MACROMOLECULAR BIOSCIENCE

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Preparation and in Vitro Antimicrobial Activity of Silver-Bearing Degradable Polymeric Nanoparticles of Polyphosphoester-block-Poly(l-lactide)

(2015) Young H. Lim et al.   ACS Nano

Poly(phosphoester)s: A New Platform for Degradable Polymers

(2015) Tobias Steinbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers

(2015) Dao Feng Xiang et al.   BIOCHEMISTRY

Investigation into the Relaxation Dynamics of Polymer–Protein Conjugates Reveals Surprising Role of Polymer Solvation on Inherent Protein Flexibility

(2015) Daniela Russo et al.   BIOMACROMOLECULES

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation

(2015) Jana Herzberger et al.   CHEMICAL REVIEWS

Protein–polymer conjugation—moving beyond PEGylation

(2015) Yizhi Qi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using111Ag as a radiotracer

(2015) Tolulope A. Aweda et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of polyphosphodiesters by ring-opening polymerization of cyclic phosphates bearing allyl phosphoester protecting groups

(2015) Benoït Clément et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Aliphatic Polyethers: Classical Polymers for the 21st Century

(2015) Rebecca Klein et al.   MACROMOLECULAR RAPID COMMUNICATIONS

A Library of Well-Defined and Water-Soluble Poly(alkyl phosphonate)s with Adjustable Hydrolysis

(2015) Thomas Wolf et al.   MACROMOLECULES

Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

(2015) Fuwu Zhang et al.   Nanoscale

Process for protein PEGylation

(2014) David Pfister et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Holistic Assessment of Covalently Labeled Core–Shell Polymeric Nanoparticles with Fluorescent Contrast Agents for Theranostic Applications

(2014) Tiffany P. Gustafson et al.   LANGMUIR

Synthesis and Topological Trapping of Cyclic Poly(alkylene phosphates)

(2014) Tyler S. Stukenbroeker et al.   MACROMOLECULES

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Galactosylated biodegradable poly(ε-caprolactone-co-phosphoester) random copolymer nanoparticles for potent hepatoma-targeting delivery of doxorubicin

(2014) Yunfeng Tao et al.   Polymer Chemistry

Water-Soluble Poly(phosphonate)s via Living Ring-Opening Polymerization

(2014) Tobias Steinbach et al.   ACS Macro Letters

Polyphosphoester-Based Cationic Nanoparticles Serendipitously Release Integral Biologically-Active Components to Serve as Novel Degradable Inducible Nitric Oxide Synthase Inhibitors

(2013) Yuefei Shen et al.   ADVANCED MATERIALS

Anti-polyethyleneglycol Antibody Response to PEGylated Substances

(2013) Tatsuhiro Ishida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Treatment of industrial wastewater with high content of polyethylene glycols by Fenton-like reaction system (Fe0/H2O2/H2SO4)

(2013) Tomáš Mackul’ak et al.   Desalination and Water Treatment

A Simple and Efficient Synthesis of an Acid-Labile Polyphosphoramidate by Organobase-Catalyzed Ring-Opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment

(2013) Shiyi Zhang et al.   MACROMOLECULES

Synthesis and characterization of a new multifunctional polymeric prodrug paclitaxel–polyphosphoester–folic acid for targeted drug delivery

(2013) Guoyi Zhang et al.   Polymer Chemistry

Microstructure analysis of biocompatible phosphoester copolymers

(2013) Tobias Steinbach et al.   Polymer Chemistry

Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles

(2013) Shiyi Zhang et al.   Chemical Science

Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles

(2013) Mahmoud Elsabahy et al.   Scientific Reports

Construction of a Reactive Diblock Copolymer, Polyphosphoester-block-Poly(l-lactide), as a Versatile Framework for Functional Materials That Are Capable of Full Degradation and Nanoscopic Assembly Formation

(2013) Young H. Lim et al.   ACS Macro Letters

Doxorubicin Conjugate of Poly(Ethylene Glycol)-Block-Polyphosphoester for Cancer Therapy

(2013) Chun-Yang Sun et al.   Advanced Healthcare Materials

Protein corona formation around nanoparticles – from the past to the future

(2013) Pablo del Pino et al.   Materials Horizons

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

(2012) You-Yong Yuan et al.   ADVANCED MATERIALS

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Hypersensitivity to Polyethylene Glycols

(2012) Sapna Shah et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation

(2012) Pengcheng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived from a Polyphosphoester-Based Biomimetic Block Copolymer System

(2012) Shiyi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Strategies for the Synthesis of Functional and Well-Defined Polyphosphoesters

(2012) Benoît Clément et al.   MACROMOLECULES

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

(2012) Zhou J. Deng et al.   Nanotoxicology

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Reversibly light-responsive micelles constructed via a simple modification of hyperbranched polymers with chromophores

(2012) Chao-Jian Chen et al.   POLYMER

Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)

(2012) Michel Vert et al.   PURE AND APPLIED CHEMISTRY

Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression

(2011) Tian-Meng Sun et al.   ACS Nano

Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery

(2011) Xian-Zhu Yang et al.   ACS Nano

Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery

(2011) Tacey X. Viegas et al.   BIOCONJUGATE CHEMISTRY

Cross-Linked PEG via Degradable Phosphate Ester Bond: Synthesis, Water-Swelling, and Application as Drug Carrier

(2011) Zhaoxing Liu et al.   BIOMACROMOLECULES

Phosphorus-Containing Polymers: A Great Opportunity for the Biomedical Field

(2011) Sophie Monge et al.   BIOMACROMOLECULES

A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy

(2011) Cheng-Qiong Mao et al.   BIOMATERIALS

Ring-opening bulk polymerization of five- and six-membered cyclic phosphonates using maghnite, a nontoxic proton exchanged montmorillonite clay

(2011) Karima Oussadi et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

(2011) Rochelle R. Arvizo et al.   PLoS One

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hyperbranched Polyphosphates for Drug Delivery Application: Design, Synthesis, and In Vitro Evaluation

(2010) Jinyao Liu et al.   BIOMACROMOLECULES

Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting

(2010) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and Micellization of pH/Temperature-Responsive Double-Hydrophilic Diblock Copolymers Polyphosphoester-block-poly[2-(dimethylamino)ethyl methacrylate] Prepared via ROP and ATRP

(2010) Xu Liu et al.   MACROMOLECULES

Synthesis of Well-Defined Thermoresponsive Polyphosphoester Macroinitiators Using Organocatalysts

(2010) Yasuhiko Iwasaki et al.   MACROMOLECULES

Biodegradable Main-Chain Phosphate-Caged Fluorescein Polymers for the Evaluation of Enzymatic Activity

(2010) Kazuo Tanaka et al.   MACROMOLECULES

Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities☆

(2009) Ruth Duncan et al.   ADVANCED DRUG DELIVERY REVIEWS

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

(2009) William W. Metcalf et al.   Annual Review of Biochemistry

Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

(2009) Ling-Yan Tang et al.   BIOCONJUGATE CHEMISTRY

Biodegradable vesicular nanocarriers based on poly(ɛ-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery

(2009) Feng Wang et al.   POLYMER

Cloning and Overexpression of Alkaline Phosphatase PhoK from Sphingomonas sp. Strain BSAR-1 for Bioprecipitation of Uranium from Alkaline Solutions

(2008) K. S. Nilgiriwala et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility, and Hydrolytic Degradation

(2008) Yu-Cai Wang et al.   BIOMACROMOLECULES

Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery

(2008) Tian-Meng Sun et al.   BIOMATERIALS

Peptide/protein–polymer conjugates: synthetic strategies and design concepts

(2008) Marc A. Gauthier et al.   CHEMICAL COMMUNICATIONS

PEGylation of Nanocarrier Drug Delivery Systems: State of the Art

(2008) Melissa D. Howard et al.   Journal of Biomedical Nanotechnology

Functionalized micelles from block copolymer of polyphosphoester and poly(ɛ-caprolactone) for receptor-mediated drug delivery

(2008) Yu-Cai Wang et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and characterization of amphiphilic block copolymer of polyphosphoester and poly(L-lactic acid)

(2008) Xian-Zhu Yang et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process

(2008) I. Hamad et al.   MOLECULAR IMMUNOLOGY

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Self-Assembled Micelles of Biodegradable Triblock Copolymers Based on Poly(ethyl ethylene phosphate) and Poly(ϵ-caprolactone) as Drug Carriers

(2007) Yu-Cai Wang et al.   BIOMACROMOLECULES