Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2020, Issue 47, Pages 7327-7332Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001363
Keywords
Antimicrobial photodynamic therapy; Phthalocyanines; Chitosan; Hydrogel; Coating
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Funding
- Deutsche Forschungsgemeinschaft DFG [GA2362/2-1]
- Fonds der Chemischen Industrie
- Westfalischee-Wilhelms-Universitat Munster
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Hydrogels are attractive materials for many biomedical applications, including drug delivery and wound healing. A light-triggered antibacterial activity can be conferred to the material with the introduction of appropriate photosensitizers (PS). In this study, we have synthesized water-soluble silicon(IV)phthalocyanine derivative (SiPc) that contains four carboxylic groups on the periphery of the macrocycle. Obtained PS serves not only as an active chromophore but also as a cross-linking gelator, enabling simple and easy synthesis of chitosan conjugate (SiPcCh). Although UV/Vis and fluorescence spectroscopic methods showed that both free and conjugated PS are non-aggregated in water media, only SiPcCh possess remarkable antibacterial effect against Gram-positive B. subtilis and Gram-negative E. coli.
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