Signaling networks in joint development

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones

(2016) Katsuhiko Amano et al.   BONE

FGFR2c-mediated ERK–MAPK activity regulates coronal suture development

(2016) Miles J. Pfaff et al.   DEVELOPMENTAL BIOLOGY

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

(2016) Jason S. Rockel et al.   JOURNAL OF CLINICAL INVESTIGATION

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

(2016) Ryo Nakamichi et al.   Nature Communications

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

(2016) Yulia Shwartz et al.   Cell Reports

TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions

(2016) Jennifer Zieba et al.   PLoS Genetics

A Genetic-Pathophysiological Framework for Craniosynostosis

(2015) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation

(2015) A. Ray et al.   DEVELOPMENT

BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints

(2015) Shailesh Agarwal et al.   DEVELOPMENTAL BIOLOGY

The suture provides a niche for mesenchymal stem cells of craniofacial bones

(2015) Hu Zhao et al.   NATURE CELL BIOLOGY

Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

(2014) Rebecca A Rolfe et al.   BMC GENOMICS

Erg cooperates with TGF-β to control mesenchymal differentiation

(2014) Megan K. Cox et al.   EXPERIMENTAL CELL RESEARCH

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

(2014) H. Ogawa et al.   GENES & DEVELOPMENT

Genesis and morphogenesis of limb synovial joints and articular cartilage

(2014) Rebekah S. Decker et al.   MATRIX BIOLOGY

Wnt Signaling Activates Shh Signaling in Early Postnatal Intervertebral Discs, and Re-Activates Shh Signaling in Old Discs in the Mouse

(2014) Tamara Winkler et al.   PLoS One

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament

(2013) Y. Sugimoto et al.   DEVELOPMENT

Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals

(2013) D. Corallo et al.   DEVELOPMENT

Pax1 acts as a negative regulator of chondrocyte maturation

(2013) Aki Takimoto et al.   EXPERIMENTAL CELL RESEARCH

c-Jun is required for the specification of joint cell fates

(2013) A. Kan et al.   GENES & DEVELOPMENT

ThePtch1DLmouse: A new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects

(2013) Weiguo Feng et al.   GENESIS

Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2)

(2013) Roman H. Khonsari et al.   HUMAN MOLECULAR GENETICS

Absence of Endochondral Ossification and Craniosynostosis in Posterior Frontal Cranial Sutures of Axin2−/− Mice

(2013) Björn Behr et al.   PLoS One

Similar cellular migration patterns from niches in intervertebral disc and in knee-joint regions detected by in situ labeling: an experimental study in the New Zealand white rabbit

(2013) Helena Henriksson et al.   Stem Cell Research & Therapy

Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1

(2012) R. A. Deckelbaum et al.   DEVELOPMENT

Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome

(2012) Greg Holmes et al.   DEVELOPMENTAL BIOLOGY

Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: Implications for evolution of the vertebrate disc

(2012) Bradley J. Bruggeman et al.   DEVELOPMENTAL DYNAMICS

Characterization of the annulus fibrosus-vertebral body interface: identification of new structural features

(2012) Y. S. Nosikova et al.   JOURNAL OF ANATOMY

Prevention of Premature Fusion of Calvarial Suture in GLI-Kruppel Family Member 3 (Gli3)-deficient Mice by Removing One Allele of Runt-related Transcription Factor 2 (Runx2)

(2012) Yukiho Tanimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs

(2012) Kyung-Suk Choi et al.   MECHANISMS OF DEVELOPMENT

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

The BMP Ligand Gdf6 Prevents Differentiation of Coronal Suture Mesenchyme in Early Cranial Development

(2012) Dawn E. Clendenning et al.   PLoS One

Regeneration of Limb Joints in the Axolotl (Ambystoma mexicanum)

(2012) Jangwoo Lee et al.   PLoS One

An Osteological and Histological Investigation of Cranial Joints in Geckos

(2011) Samantha L. Payne et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling

(2011) Kelly Lenton et al.   GENESIS

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos

(2011) Karen A. Roddy et al.   PLoS One

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

(2011) K.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling

(2011) Naoki Kondo et al.   SPINE

Nuclei Pulposi Formation From the Embryonic Notochord Occurs Normally in GDF-5-Deficient Mice

(2011) Jennifer A. Maier et al.   SPINE

Support of Concept That Migrating Progenitor Cells From Stem Cell Niches Contribute to Normal Regeneration of the Adult Mammal Intervertebral Disc

(2011) Helena Barreto Henriksson et al.   SPINE

β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis

(2010) Anthony J Mirando et al.   BMC DEVELOPMENTAL BIOLOGY

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc

(2010) Philip Sohn et al.   BMC DEVELOPMENTAL BIOLOGY

Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice

(2010) Yingli Wang et al.   BMC DEVELOPMENTAL BIOLOGY

Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells

(2010) Hai-Yun Yen et al.   DEVELOPMENTAL BIOLOGY

Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head

(2010) Paul G. Roybal et al.   DEVELOPMENTAL BIOLOGY

Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine

(2010) Christina Mundy et al.   DEVELOPMENTAL BIOLOGY

Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons

(2010) Tsunemitsu Soeda et al.   GENESIS

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

(2010) D. P. C. Rice et al.   HUMAN MOLECULAR GENETICS

Sonic hedgehog in temporal control of somite formation

(2010) T. P. Resende et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

(2010) T. Maruyama et al.   Science Signaling

EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis

(2009) M.-C. Ting et al.   DEVELOPMENT

FGF9 monomer–dimer equilibrium regulates extracellular matrix affinity and tissue diffusion

(2009) Masayo Harada et al.   NATURE GENETICS

Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model

(2009) K Shen et al.   Orthodontics & Craniofacial Research

Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging

(2009) Chitra Lekha Dahia et al.   SPINE

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

(2008) Eiki Koyama et al.   DEVELOPMENTAL BIOLOGY

A critical evaluation of specific aspects of joint development

(2008) A.A. Pitsillides et al.   DEVELOPMENTAL DYNAMICS

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

The skeletal kinematics of lung ventilation in three basal bird taxa (emu, tinamou, and guinea fowl)

(2008) Leon P.A.M. Claessens   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Cell lineage in mammalian craniofacial mesenchyme

(2008) Toshiyuki Yoshida et al.   MECHANISMS OF DEVELOPMENT

A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis

(2007) Liangjun Yin et al.   BONE