Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 207, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112741
Keywords
Quorum sensing; Vibrio harveyi; Quorum sensing inhibitors; Target
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Funding
- National Key R&D Program of China [2018YFC0311003, 2018YFC0311002]
- 111-National Overseas Expertise Introduction Center for Green Pharmaceutical Discipline Innovation [D17012]
- Open Research Program of the Key Laboratory of Marine Ecosystem Dynamics (MED), MNR [LMEB201704]
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Vibrio harveyi is a marine bacterial pathogen which infects a wide range of marine organisms and results in severe loss. Antibiotics have been used for prophylaxis and treatment of V. harveyi infection. However, antibiotic resistance is a major public health threat to both human and animals. Therefore, there is an urgent need for novel antimicrobial agents with new modes of action. In V. harveyi, many virulence factors production and bioluminescence formation depend on its quorum sensing (QS) network. Therefore, the QS system has been widely investigated as an effective potential target for the treatment of V. harveyi infection. This perspective focuses on the quorum sensing inhibitors (QSIs) of V. harveyi QS systems (LuxM/N, LuxS/PQ, and CqsA/S) and evaluates medicinal chemistry strategies. (C) 2020 Elsevier Masson SAS. All rights reserved.
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