Journal
DEVELOPMENTAL CELL
Volume 39, Issue 2, Pages 131-132Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2016.10.005
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Funding
- NCI NIH HHS [R01 CA168872] Funding Source: Medline
- NIGMS NIH HHS [F32 GM119283, R01 GM111700] Funding Source: Medline
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In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition.
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