Article
Cell Biology
Inka Berglar, Stephanie Hehlgans, Andrej Wehle, Caterina Roth, Christel Herold-Mende, Franz Roedel, Donat Koegel, Benedikt Linder
Summary: In this study, we investigated the role of CHRDL1 in glioma stem-like cells and found that depletion of CHRDL1 reduces stemness and enhances radiation sensitivity. Additionally, high expression of CHRDL1 may also serve as a marker protein for determining BMP4 susceptibility.
Article
Biochemistry & Molecular Biology
Shanchun Guo, Vanajothi Ramar, Alyssa A. Guo, Talib Saafir, Hannah Akpobiyeri, Breanna Hudson, Jason Li, Mingli Liu
Summary: TRPM7 regulates glioma cells' stemness through STAT3, and FOSL1 acts as an oncogene to promote glioma proliferation and invasion. FOSL1 affects the expression of GSC markers CD133 and ALDH1, and is required for maintaining stem cell activity in glioma cells. TRPM7 induces FOSL1 transcriptional activation mediated by STAT3, and TRPM7, ALDH1, and FOSL1 protein expressions are associated with malignant glioma grades.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Environmental Sciences
Yuxiang Dai, Tianfu Yu, Chen Yu, Tianyu Lu, Lu Zhou, Chuandong Cheng, Hongbin Ni
Summary: ISG15 is upregulated in glioma tissues and positively correlated with stemness markers. It interacts with Oct4 protein, induces its ISGylation, and enhances its stability, thereby regulating glioma cell stemness.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Neurosciences
Hyun-Jin Kim, Hang Yeon Jeong, Don Carlo Batara, Changjong Moon, Seongsoo Lee, Suk Jun Lee, Sang-Ik Park, Moon-Chang Choi, Sung-Hak Kim
Summary: This study reveals the regulatory role of ADAMTS3 in glioma stem cells, suggesting its potential as a therapeutic target for treating GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Xinde Zhao, Ming Zhou, Yong Yang, Minjie Luo
Summary: The study reveals that OTUB1 is highly expressed in glioma tissues, and knocking down OTUB1 can reduce the stemness of glioma cells. OTUB1 stabilizes the SLC7A11 protein, affecting ferroptosis. Clinical samples show a positive correlation between OTUB1 and SLC7A11 expression.
Article
Genetics & Heredity
Lairong Song, Xulei Huo, Xiaojie Li, Xiaoying Xu, Yi Zheng, Da Li, Junting Zhang, Ke Wang, Liang Wang, Zhen Wu
Summary: SERPINF1 expression is associated with overall survival in glioma patients and its knockdown suppresses the proliferation, invasion, and migration of glioma cells. SERPINF1 is also highly expressed in glioma stem cells. Notch signaling activation and transcription factors STAT1, CREM, and NR2F2 may be involved in the molecular functions and regulation of SERPINF1 in glioma.
Article
Medicine, Research & Experimental
Chuanhong Zhong, Bei Tao, Fangli Tang, Xiaobo Yang, Tangming Peng, Jian You, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Lilei Peng
Summary: Cancer development, especially in glioma, involves complex interactions between extracellular matrix components, such as type I collagen and fibronectin, and signaling pathways like PI3K/AKT/SOX2 and CDC42/YAP-1/NUPR1/Nestin. Inhibiting the integrin alpha v beta 3 pathway shows promise in suppressing tumor growth and reducing cancer relapse, providing new insights for potential glioma therapy strategies.
Article
Clinical Neurology
Xun Kang, Jing Chen, Jian-feng Hou
Summary: This study demonstrates that HSP90 accelerates stemness and enhances glycolysis in glioma cells. Inhibition of glycolysis with 2DG prevented stemness, suggesting a potential therapeutic target for anti-glioma treatment.
Article
Neurosciences
Xiao-Liang Wang, Bao-Hua Jiao, Jian-Liang Wu, Jian-Kai Yang, Yu-Hua Hu, Kai Cui
Summary: This study investigates the role of RIP2 in regulating the stemness of glioma cells and their resistance to chemotherapy. RIP2 was found to mediate resistance to temozolomide by activating the NF-kappa B pathway and upregulating the expression of CD133 and SOX-2, both of which are involved in stemness maintenance. Targeting the RIP2/NF-kappa B pathway may be a potential therapeutic strategy for temozolomide-resistant gliomas.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Oncology
Tracy J. Berg, Carolina Marques, Vasiliki Pantazopoulou, Elinn Johansson, Kristoffer von Stedingk, David Lindgren, Pauline Jeannot, Elin J. Pietras, Tobias Bergstrom, Fredrik J. Swartling, Valeria Governa, Johan Bengzon, Mattias Belting, Hakan Axelson, Massimo Squatrito, Alexander Pietras
Summary: Pre-irradiated astrocytes enhance glioma stemness and survival, while irradiation of the brain creates a tumor-supportive microenvironment. Extracellular matrix proteins derived from irradiated astrocytes and TGM2 have been identified as key factors in promoting glioma stemness and radioresistance.
Article
Oncology
Ruifan Xie, Tobias Kessler, Julia Grosch, Ling Hai, Varun Venkataramani, Lulu Huang, Dirk C. Hoffmann, Gergely Solecki, Miriam Ratliff, Matthias Schlesner, Wolfgang Wick, Frank Winkler
Summary: A novel functional approach was developed to detect and characterize glioma cell subpopulations, revealing that TM-connected glioblastoma cells exhibit stem-like features and high radioresistance. These cells showed a particular adaptability to radiotherapy.
Article
Medicine, Research & Experimental
Fangting You, Cheng Li, Shicheng Zhang, Qiaoshan Zhang, Zhiyuan Hu, Yuhui Wang, Tong Zhang, Qingming Meng, Rutong Yu, Shangfeng Gao
Summary: In this study, we investigated the efficacy of an antidiabetic drug Sitagliptin in inhibiting the survival, stemness, and autophagy of GBM cells and enhancing the cytotoxicity of TMZ. The results showed that Sitagliptin can effectively inhibit cell proliferation, induce apoptosis, suppress self-renewal and stemness of GSCs. Furthermore, Sitagliptin could inhibit TMZ-induced protective autophagy and enhance the cytotoxicity of TMZ in glioma cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Min Zhang, Zhi Dai, Xudong Zhao, Gan Wang, Ren Lai
Summary: The study demonstrated that anticarin beta can effectively suppress proliferation and induce apoptosis in glioma cells, decrease stemness gene expression, induce DNA damage, and eventually lead to apoptosis by regulating oncogene expression. Overall, anticarin beta shows promising potential as an inhibitor for malignant glioma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang
Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.