Article
Environmental Sciences
Minxue Shen, Yi Xiao, Yuzhou Huang, Danrong Jing, Juan Su, Dan Luo, Yanying Duan, Shuiyuan Xiao, Jie Li, Xiang Chen
Summary: This study found an association between serum PFAS and the incidence of chronic spontaneous urticaria (CSU) in adults, with participants having higher concentrations of certain PFAS being more likely to develop CSU. By analyzing a mediation effect model with long-term follow-up and various biomarkers, potential mechanisms linking PFAS to CSU incidence were revealed.
Article
Environmental Sciences
Yanqiu Ou, Xiaowen Zeng, Shao Lin, Michael S. Bloom, Fengzhen Han, Xiaohua Xiao, Hui Wang, Rosemary Matala, Xiaohong Li, Yanji Qu, Zhiqiang Nie, Guanghui Dong, Xiaoqing Liu
Summary: The study found that maternal gestational exposure to certain PFAS may increase the risk of congenital heart defects in children, particularly for septal and conotruncal defects. Larger studies are needed to confirm these results and to further investigate the potential teratogenic effects of other newly introduced PFAS, as well as their associations with different CHD subtypes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Julie A. D. Van, Yihan Luo, Jayne S. Danska, Feihan Dai, Stacey E. Alexeeff, Erica P. Gunderson, Hannes Rost, Michael B. Wheeler
Summary: This study comprehensively characterized the postpartum profiles of women shortly after a GDM pregnancy and identified key mechanisms responsible for the progression to overt type 2 diabetes. The study revealed an inflammatory response and disturbances in amino acids and triglycerides that are associated with the development of diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: The study found a negative association between the use of alendronate and the risk of developing type 2 diabetes, with a dose-response relationship observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Peiwen Li, Yali Xu, Zhaoyang Li, Xu Cheng, Chengyong Jia, Shiyang Zhang, Jun An, Xin Zhang, Yan Yan, Meian He
Summary: This study investigated the association between polychlorinated biphenyls (PCBs) exposure and incident type 2 diabetes mellitus (T2DM), as well as the relationship between PCBs and 5-year fasting blood glucose (FBG) changes. The results showed significant associations between non-dioxin-like PCBs (NDL-PCBs) and higher T2DM incidence, as well as positive associations between NDL-PCBs and changes in FBG. It was concluded that PCBs increased T2DM incidence through lipid metabolic pathways.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Fei Wang, Ying Zhang, Shiyang Zhang, Xu Han, Yue Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study found a U-shaped association between serum BPA levels and the risk of type 2 diabetes. Additionally, individuals with higher serum BPA levels and a genetic risk for diabetes had higher fasting plasma glucose levels and a higher risk of type 2 diabetes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Endocrinology & Metabolism
Sarah Charlier, Janina Vavanikunnel, Claudia Becker, Susan S. Jick, Christian Meier, Christoph R. Meier
Summary: The study found that patients with good glycemic control who were treated with metformin monotherapy had a lower risk of fractures, while glycemic control in patients receiving other antidiabetic medications was not associated with fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Bihu Liu, Bincai Wei, Meile Mo, Yanye Song, Chuanqiao Tang, Peng Tang, Xiaojing Guo, Chao Tan, Shun Liu, Dongping Huang, Xiaoqiang Qiu
Summary: This study found that combined exposure to nine PFASs had a positive effect on the development of hypertensive disorders of pregnancy (HDP) in women in Guangxi, China. Specifically, PFOS and PFBS were positively associated with HDP risk, while PFHxS and PFHpA were negatively associated.
Article
Environmental Sciences
Yuqian Li, Xinyan Lu, Nanyang Yu, Aijing Li, Taifeng Zhuang, Letian Du, Song Tang, Wei Shi, Hongxia Yu, Maoyong Song, Si Wei
Summary: This study evaluated the associations between metabolites in maternal and cord serum and internal exposure to common PFASs. It identified multiple metabolites and pathways linked to PFAS exposure in pregnant women and fetuses, indicating the potential application of metabolome-wide association studies in studying toxic mechanisms of PFASs. Additional research is required to confirm causation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Richard H. Lee, James Bain, Michael Muehlbauer, Olga Ilkayeva, Carl Pieper, Doug Wixted, Cathleen Colon-Emeric
Summary: Older adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density. Additional markers of fracture risk, including non-esterified fatty acids and specific amino acids, were identified in this study.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Jia Liu, Lu Wang, Yun Qian, Qian Shen, Man Yang, Yunqiu Dong, Hai Chen, Zhijie Yang, Yaqi Liu, Xuan Cui, Hongxia Ma, Guangfu Jin
Summary: This study aimed to identify novel metabolic markers for future type 2 diabetes (T2D) risk in Han Chinese individuals and determine if the combined effect of metabolic and genetic markers improves prediction accuracy. The researchers found that abnormal levels of 5 metabolites were associated with increased future T2D risk. The genetic risk score (GRS) based on 20 single nucleotide polymorphisms (SNPs) was also significantly associated with T2D risk and improved prediction models when combined with metabolites and clinical factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Chenchun Chen, Yanye Song, Peng Tang, Dongxiang Pan, Bincai Wei, Jun Liang, Yonghong Sheng, Qian Liao, Dongping Huang, Shun Liu, Xiaoqiang Qiu
Summary: This study aimed to investigate the association between prenatal exposure to perfluoroalkyl substances (PFASs) and intrauterine growth restriction (IUGR). By measuring the concentrations of nine PFASs in maternal serum, the study found that certain PFASs were positively associated with the risk of IUGR. The findings suggest that prenatal exposure to single and mixtures of PFASs may increase the risk of IUGR, with the concentration of PFHpA having the largest impact.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Shiyang Zhang, Xu Cheng, Chengyong Jia, Jun An, Xin Zhang, Peiwen Li, Youbing Guan, Yan Yan, Zhuoya Zhao, Yuenan Liu, Tao Jing, Meian He
Summary: There were no significant associations found between serum PAEs levels and T2DM in the overall population, but current alcohol drinkers exposed to higher levels of DnBP, EDBP, and ELMW had a higher risk of T2DM. Furthermore, significant potential interactions were observed among certain PAEs and drinking status on T2DM risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Maryam Tohidi, Mehdi Hedayati, Fereidoun Azizi, Maryam S. Daneshpour
Summary: This study investigates the association of common KCNJ11 variants with type 2 diabetes (T2D) in Iranian adults and conducts a meta-analysis. The results show that KCNJ11 variants are not associated with T2D incidence in Iranian adults, but certain variants are significantly associated with increased T2D susceptibility in diverse populations. The meta-analysis also highlights the impact of sample size on the magnitude of pooled genetic effect size.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Lang Pan, Lu Chen, Jun Lv, Yuanjie Pang, Yu Guo, Pei Pei, Huaidong Du, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Weiwei Gong, Junshi Chen, Canqing Yu, Zhengming Chen, Liming Li, Edward D. China Kadoorie Biobank Collaborative Grp
Summary: This study found that egg consumption is associated with several metabolic markers in the Chinese population, and these markers show opposite patterns in relation to cardiovascular disease risk.
Article
Geriatrics & Gerontology
Adrian Carballo-Casla, Esther Garcia-Esquinas, Esther Lopez-Garcia, Carolina Donat-Vargas, Jose R. Banegas, Fernando Rodriguez-Artalejo, Rosario Ortola
Summary: This study found that an increase in the inflammatory potential of diet was associated with a higher incidence of pain in the following years, especially among less physically active individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Stefania Noerman, Jyrki K. Virtanen, Marko Lehtonen, Carl Brunius, Kati Hanhineva
Summary: The study aimed to identify fasting serum metabolites associated with whole grain intake in a free-living population. The findings suggested strong associations between whole grain intake and several metabolites, which remained significant even after adjusting for potential confounders. These metabolites have the potential to serve as robust biomarkers for whole grain consumption.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Tao Yan, Lin Shi, Kun Xu, Jinyu Bai, Ruixue Wen, Xia Liao, Xiaoshuang Dai, Qian Wu, Lingxia Zeng, Wen Peng, Youfa Wang, Hong Yan, Shaonong Dang, Xin Liu
Summary: Reducing consumption of sugar-sweetened beverages is crucial for public health due to their limited nutritional value and links to obesity and metabolic diseases. Gut microbiota-related metabolites play a significant role in mediating the associations between dietary intake and metabolic health outcomes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Hematology
Shuai Yuan, Olga E. Titova, Ke Zhang, Wanglong Gou, Tessa Schillemans, Pradeep Natarajan, Jie Chen, Xue Li, Agneta akesson, Maria Bruzelius, Derek Klarin, Scott M. Damrauer, Susanna C. Larsson
Summary: We conducted cohort and Mendelian randomisation analyses to explore the associations between circulating proteins and risk of venous thromboembolism (VTE), with the aim of providing evidence for disease prevention and drug development. The cohort analysis identified 21 proteins significantly associated with VTE risk, while the machine-learning model highlighted the importance of body mass index and von Willebrand factor (vWF) in predicting VTE risk. The Mendelian randomisation analysis revealed causal associations between genetically predicted levels of vWF, SERPINE1, EPHB4, TYRO3, TNFRSF11A, and BOC and VTE risk.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Environmental Sciences
T. Schillemans, I. A. Bergdahl, K. Hanhineva, L. Shi, C. Donat-Vargas, J. Koponen, H. Kiviranta, R. Landberg, A. akesson, C. Brunius
Summary: The widespread environmental pollutants PFAS have been repeatedly linked to elevated serum cholesterol in humans, but the underlying mechanisms are still unclear. In this study, we investigated the associations between PFAS-related metabolite features and plasma cholesterol and triglyceride concentrations. The results indicated that longer chain PFAS may affect glycerophospholipid metabolism, leading to changes in triglyceride levels.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Tao Yan, Lin Shi, Tianqi Liu, Xiangnan Zhang, Minmin Yang, Wen Peng, Xiaomin Sun, Lijing Yan, Xiaoshuang Dai, Xinbing Yang
Summary: This study demonstrates the disturbing effects of high fat diet on tryptophan metabolism and gut dysbacteriosis, as well as the beneficial effects of wheat bran in inhibiting tryptophan metabolism and promoting health promoting bacteria.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Xiangnan Zhang, Lin Shi, Nan Wang, Qiannan Li, Liansheng Zhang, Ning Han, Tao Yan, Daoyuan Ren, Bo Zhang, Yan Zhao, Xingbin Yang
Summary: This study found that polyphenols extracted from Fu brick tea can prevent and alleviate ulcerative colitis by reshaping the gut microbiota and promoting the transformation of tryptophan into I3A, which enhances AHR activity to improve colitis symptoms and intestinal epithelial homeostasis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Health Care Sciences & Services
Adrian Abbasi-Perez, Miguel Angel Alvarez-Mon, Carolina Donat-Vargas, Miguel A. Ortega, Jorge Monserrat, Ana Perez-Gomez, Melchor Alvarez-Mon
Summary: Twitter has become a popular platform for sharing information on rheumatology drugs, with patients, healthcare professionals, institutions, and others actively participating. This study analyzed tweets related to 16 rheumatology drugs to determine the volume, content, and type of users. Methotrexate (MTX) was the most discussed drug, with patients and their relatives being the main contributors, while professionals, institutions, and patient associations focused on TNF inhibitors. Medical content prevailed in most tweets, with efficacy being the most discussed topic. Inappropriate or fake content was found to be very low.
Article
Biology
Aleksi Husso, Tiina Pessa-Morikawa, Ville Mikael Koistinen, Olli Karkkainen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva, Mikael Niku
Summary: Maternal microbiota has a significant impact on fetal development, with gene expression differences in the fetal intestines, brains, and placenta associated with microbial metabolite concentrations. Male fetuses may be more susceptible to microbial modulation, affecting genes important for immune system, neurophysiology, translation, and energy metabolism before birth. Several microbial metabolites have been identified in this context, with many important metabolites yet to be discovered.
Article
Nutrition & Dietetics
Mari Naatanen, Anna Karlund, Santtu Mikkonen, Anton Klavus, Otto Savolainen, Marko Lehtonen, Leila Karhunen, Kati Hanhineva, Marjukka Kolehmainen
Summary: This study investigated the effect of two isocaloric 24-week weight maintenance diets on metabolism and identified metabolite features associated with successful weight loss maintenance. It was found that the dietary fiber, protein, and fat content of the diet influenced amino acid and lipid metabolism, and increased abundance of certain phospholipids and free fatty acids was associated with better weight loss maintenance.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Carolina Donat-Vargas, Victor Mico, Rodrigo San-Cristobal, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Montserrat Fito, Angel Maria Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Miguel Damas-Fuentes, Jose Lapetra, Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep Antoni Tur, Sergio Cinza-Sanjurjo, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Claudia Causso, Emilio Ros, Estefania Toledo, Josep Maria Manzanares, Carolina Ortega-Azorin, Olga Castaner, Patricia Judith Pena-Orihuela, Juan Manuel Zazo, Carlos Munoz Bravo, Diego Martinez-Urbistondo, Alice Chaplin, Rosa Casas, Naomi Cano Ibanez, Lucas Tojal-Sierra, Ana Maria Gomez-Perez, Elena Pascual Roquet-Jalmar, Cristina Mestre, Rocio Barragan, Helmut Schroder, Antonio Garcia-Rios, Inmaculada Candela Garcia, Miguel Ruiz-Canela, Nancy Babio, Mireia Malcampo, Lidia Daimiel, Alfredo Martinez
Summary: Anemia and lower levels of anemia markers are associated with inferior cognitive function, worse executive function, and poorer physical component of quality of life. These effects are particularly pronounced in individuals with diabetes. Dietary iron intake does not influence these outcomes.
Article
Medicine, General & Internal
Carolina Donat-Vargas, Tessa Schillemans, Hannu Kiviranta, Panu Rantakokko, Ulf de Faire, Juan Pedro Arrebola, Alicja Wolk, Karin Leander, Agneta Akesson
Summary: This study evaluated the association between combined exposure to multiple organochlorine compounds and cardiovascular disease in the general population. The study found that exposure to organochlorines was associated with an increased risk of cardiovascular events, highlighting the need for measures to reduce these exposures.
Article
Environmental Sciences
Bianca Cox, Natasha Wauters, Andrea Rodriguez-Carrillo, Lutzen Portengen, Antje Gerofke, Marike Kolossa-Gehring, Sanna Lignell, Anna Karin Lindroos, Lucia Fabelova, Lubica Palkovicova Murinova, Anteneh Desalegn, Nina Iszatt, Tessa Schillemans, Agneta Akesson, Ann Colles, Elly Den Hond, Gudrun Koppen, Nicolas Van Larebeke, Greet Schoeters, Eva Govarts, Sylvie Remy
Summary: Early puberty is associated with negative health outcomes, and the decrease in age at menarche is linked to increased exposure to endocrine-disrupting compounds (EDCs). However, the evidence for the association between PFAS and phthalate exposure and age at menarche is inconsistent.
Article
Endocrinology & Metabolism
Valeria Iannone, Ambrin Farizah Babu, Johnson Lok, Carlos Gomez-Gallego, Giuseppe D'Auria, Ruben Vazquez-Uribe, Troels Holger Vaaben, Mareike Bongers, Santtu Mikkonen, Maija Vaittinen, Ida Tikkanen, Mikko Kettunen, Anton Klavus, Ratika Sehgal, Dorota Kaminska, Jussi Pihlajamaki, Kati Hanhineva, Hani El-Nezami, Morten Otto Alexander Sommer, Marjukka Kolehmainen
Summary: This study found that Escherichia coli Nissle 1917 expressing aldafermin, combined with dietary changes, can alleviate symptoms of MASLD, including reducing body weight, liver steatosis, plasma aspartate aminotransferase, and plasma cholesterol levels. RNA sequencing and metabolomics analysis revealed the downregulation of amino acid metabolism and related receptor signaling pathways, which may be implicated in the reduction of hepatic steatosis and insulin resistance.
MOLECULAR METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Maaria Kortesniemi, Stefania Noerman, Anna Karlund, Jasmin Raita, Topi Meuronen, Ville Koistinen, Rikard Landberg, Kati Hanhineva
Summary: Metabolomics has become a crucial method in nutrition research, allowing for the discovery and validation of dietary biomarkers and playing an important role in understanding the activity and functionality of gut microbiota. The field has also seen emerging developments in precision nutrition.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)