Article
Fisheries
Yukai Qin, Zhi Luo, Ke Zhao, Xingyu Nan, Yanan Guo, Weiwei Li, Qun Wang
Summary: This study identified a novel SVWC gene, named EsSVWC, in Eriocheir sinensis, which responds positively to bacterial stimulation and regulates the expression of antimicrobial peptides, thus improving the crab's resistance to bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Zhi Luo, Yu-Kai Qin, Ke Zhao, Xing-Yu Nan, Wei-Wei Li, Er-Chao Li, Qun Wang
Summary: In this study, a gene named EsCaspar was identified in Eriocheir sinensis. It was found to play a negative regulatory role in the antibacterial immune process by inhibiting the nuclear translocation of EsRelish and downregulating the expression of certain antimicrobial peptides. The excessive protein of EsCaspar in crabs reduced their resistance to bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Kexin Liu, Zhe Qu, Jingjie Hu, Zhenmin Bao, Mengqiang Wang
Summary: In this study, the QM protein gene was cloned from Eriocheir sinensis and found to play important roles in immune responses. The gene showed responses to bacterial infection and environmental pollution.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Yufan Bao, Guoqing Shen, Yanan Guo, Qun Wang, Xinpeng Fan, Weiwei Li
Summary: By studying the TNF of Eriocheir sinensis, it was found that TNF binding TNFR can affect the proliferation of hemocytes, possibly by regulating the expression of some proliferation-related genes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Huang, Xi-Mei Nie, Zheng-Jie Zhu, Xing Zhang, Bing-Zhi Li, Jia-Chun Ge, Qian Ren
Summary: A novel c-Jun NH2-terminal kinase (EsJNK) was identified and characterized in the Chinese mitten crab Eriocheir sinensis, with a determined cDNA sequence and predicted tertiary structure. EsJNK was found to be closely related to JNK homologs in other crustaceans and exhibited relatively higher expression in hemocytes, muscles, and intestines. Functional studies indicated that EsJNK may play a role in regulating the transcription of antimicrobial peptides and be involved in the antibacterial immune defense of crabs.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi Zhang, Yunhui Bai, Qiao Shi, Bin Zhou, Mengqi Ni, Jinbin Zheng, Zhaoxia Cui
Summary: A novel LRR-IG, EsLRR-IG5, was identified from Eriocheir sinensis and demonstrated to have broad-spectrum antibacterial activity. It binds to different bacteria and bacterial components and disrupts bacterial membrane integrity, leading to death. This study provides insights into the immune defense mechanism mediated by LRR-IG in crustaceans and offers potential antibacterial agents for aquaculture disease prevention and control.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Fisheries
Ying Huang, Qin Si, Shenghao Du, Jie Du, Qian Ren
Summary: In this study, a new member of the TNF superfamily, EsTNFSF, was identified from the Chinese mitten crab. EsTNFSF was found to play a crucial role in the antibacterial immune defense of E. sinensis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Fisheries
Xiaona Zhang, Guoqing Shen, Yanan Guo, Xiaoli Zhang, Yuehong Zhao, Weiwei Li, Qun Wang, Yunlong Zhao
Summary: Protein kinases of the MAPK cascade family play a crucial role in the growth and response to stress in organisms. This study identified and analyzed four MAPKK genes in the Chinese mitten crab Eriocheir sinensis. The genes were found to have conserved domains and motifs and were expressed in various tissues, with higher expression in hemocytes, hepatopancreas, and gills. Infection with Vibrio parahaemolyticus increased the mRNA levels of the MAPKK genes in hemocytes, and disruption of their expression affected the levels of antimicrobial peptides. These findings provide insights into the innate immunity of E. sinensis.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaona Zhang, Yuehong Zhao, Xiaoli Zhang, Guoqing Shen, Weiwei Li, Qun Wang
Summary: CYLD is a tumor suppressor protein that regulates the immune response to bacterial infection in crustaceans.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xingyu Nan, Ke Zhao, Yukai Qin, Yu Song, Yanan Guo, Zhi Luo, Weiwei Li, Qun Wang
Summary: The research found that the inducible reductase of interferon gamma (IFN-gamma) plays an important role in the antibacterial immunity of Chinese mitten crab. The protein promotes bacterial agglutination, clearance, and phagocytosis, and inhibits cell apoptosis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Fisheries
Ying Song, Xianyong Bu, Qincheng Huang, Xiaodan Wang, Zhideng Lin, Fang Qiao, Qingchao Shi, Jianguang Qin, Liqiao Chen
Summary: The study revealed that dietary iron levels significantly affect the growth, antioxidant status, and non-specific immunity of juvenile Chinese mitten crab. The optimal iron requirement for these crabs was found to be around 130-141 mg/kg, and dietary iron plays a crucial role in the innate immune system of E. sinensis by improving antioxidant capacity and non-specific immunity.
Article
Immunology
Wei-Feng Wang, Xiao-Yong Xie, Kang Chen, Xiu-Li Chen, Wei-Lin Zhu, Huan-Ling Wang
Summary: The Chinese horseshoe crab relies on its innate immune system for pathogen defense, but the specific mechanisms underlying its abilities to distinguish and defend against invading microbes are still unclear. Through high-throughput sequencing and bioinformatics analysis, this study identified key signaling pathways activated in the Chinese horseshoe crab's hemolymph in response to Gram-negative bacteria, shedding light on the ancient original innate immune mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Yue Sun, Chunying Yuan, Qingman Cui
Summary: The study found that thiamethoxam has acute toxic effects on Eriocheir sinensis, reducing their survival rate and impairing their immune and metabolic systems. Higher concentrations of thiamethoxam resulted in a decrease in immune cells and affected enzyme activity and antioxidant capacity in crabs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Chunling Wang, Jingyu Pan, Xiaodan Wang, Xinyu Cai, Zhideng Lin, Qingchao Shi, Erchao Li, Jian G. Qin, Liqiao Chen
Summary: The research showed that dietary N-acetylcysteine (NAC) improved growth performance and survival of Chinese mitten crab fed T-2 toxin. A dosage of 0.1% NAC effectively alleviated oxidative stress, immunodepression, and apoptosis induced by T-2 toxin.
Article
Fisheries
Changle Qi, Xiaodan Wang, Fenglu Han, Xuefeng Chen, Erchao Li, Meiling Zhang, Jian G. Qin, Liqiao Chen
Summary: In this study, it was found that arginine supplementation in the diet of juvenile Chinese mitten crab under high pH stress led to increased growth, improved antioxidant capacity, reduced inflammation and apoptosis, and enhanced immunity.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
