Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 58, Issue 4, Pages 409-421Publisher
WILEY
DOI: 10.1111/dgd.12286
Keywords
ADAM; body growth; knockout; zebrafish
Categories
Funding
- Japan Society for the Promotion of Science KAKENHI [23111513, 22122007, 25291051]
- Japan Prize Foundation
- Uehara Memorial Foundation
- Fujiwara Memorial Foundation
- Platform for Dynamic Approaches to Living System from the Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [16H04793] Funding Source: KAKEN
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ADAM (a disintegrin and metalloprotease) constitutes a family of multi-domain proteins that are involved in development, homeostasis, and disease. ADAM12 plays important roles in myogenesis and adipogenesis in mice; however, the precise physiological mechanisms are not known, and the function of this gene in other vertebrates has not been examined. In this study, we used a simple model vertebrate, the zebrafish, to investigate the functions of ADAM12 during development. Zebrafish adam12 is conserved with those of mammals in the synteny and the amino-acid sequence. We examined adam12 expression in zebrafish embryos by whole mount insitu hybridization and the promoter activity of the adam12 upstream sequence. We found that adam12 is strongly expressed in the cardiovascular system, erythroid progenitors, brain, and jaw cartilage during zebrafish development, and adam12-knockout zebrafish exhibited reduced body size in the juvenile stage without apparent morphological defects. Taken together, these results suggest that adam12 plays a significant role in the regulation of body growth during juvenile stage in zebrafish, although the precise molecular mechanisms await further study.
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