SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility

(2018) Atsushi Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

(2017) Daniel R. Scoles et al.   NATURE

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

(2017) Carlo Rinaldi et al.   Nature Reviews Neurology

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

(2017) Shira Knafo et al.   TRENDS IN NEUROSCIENCES

Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth

(2017) Catherine J. Fricano-Kugler et al.   BIOLOGICAL PSYCHIATRY

Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine

(2016) Alina Kurolap et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans

(2016) Majid Alfadhel et al.   HUMAN GENETICS

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

(2016) Shira Knafo et al.   NATURE NEUROSCIENCE

Characterization of GABA A receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells

(2016) Nina Y. Yuan et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Analysis of the brain mural cell transcriptome

(2016) Liqun He et al.   Scientific Reports

Theta-burst LTP

(2015) John Larson et al.   BRAIN RESEARCH

NMDA receptor dysfunction in autism spectrum disorders

(2015) Eun-Jae Lee et al.   CURRENT OPINION IN PHARMACOLOGY

Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive

(2015) M. R. Williams et al.   JOURNAL OF NEUROSCIENCE

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder

(2015) A K Tilot et al.   MOLECULAR PSYCHIATRY

Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice

(2015) Dario Cupolillo et al.   NEUROPSYCHOPHARMACOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

(2014) Amy E. Clipperton-Allen et al.   HUMAN MOLECULAR GENETICS

Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell Patch Clamp

(2014) Sriram Vaidyanathan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA

(2014) Linyan Meng et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Organization, control and function of extrasynaptic NMDA receptors

(2014) T. Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nuclear trafficking of Pten after brain injury leads to neuron survival not death

(2013) Choo-Peng Goh et al.   EXPERIMENTAL NEUROLOGY

Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries

(2013) S. Zhang et al.   JOURNAL OF NEUROSCIENCE

Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein

(2013) J. N. Lugo et al.   LEARNING & MEMORY

Transporters of the blood–brain and blood–CSF interfaces in development and in the adult

(2013) Norman R. Saunders et al.   MOLECULAR ASPECTS OF MEDICINE

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

(2013) Robert J. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

(2013) K. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Ion Channel Pharmacology Under Flow: Automation Via Well-Plate Microfluidics

(2012) C. Ian Spencer et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The solute carrier 6 family of transporters

(2012) Stefan Bröer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thinking Outside the Synapse: Glycine at Extrasynaptic NMDA Receptors

(2012) John A. Gray et al.   CELL

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

(2012) Eleonora Napoli et al.   PLoS One

IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-à-go-go Related Gene Channel Physiology and Pharmacology

(2011) Andrew P. Golden et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

(2010) Sandra Jurado et al.   EMBO JOURNAL

Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice

(2010) Volker Eulenburg et al.   GLIA

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Expression Profiling of the Solute Carrier Gene Family in the Mouse Brain

(2009) A. Dahlin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20)

(2009) Angelika Bröer et al.   MOLECULAR MEMBRANE BIOLOGY

Comparative genomics of autism and schizophrenia

(2009) B. Crespi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Glycine Transport Inhibitors and the Treatment of Schizophrenia

(2008) Daniel C. Javitt   BIOLOGICAL PSYCHIATRY

SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage

(2008) M.-K. I. Anas et al.   DEVELOPMENT

Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1)

(2008) Denise Manahan-Vaughan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium

(2008) J. W. Kim et al.   GENES & DEVELOPMENT

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters

(2008) Stefan Bröer et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN signaling in brain: neuropathology and tumorigenesis

(2008) R Endersby et al.   ONCOGENE

Barriers in the brain: a renaissance?

(2008) Norman R. Saunders et al.   TRENDS IN NEUROSCIENCES

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR