ATP-dependent chromatin remodeling during mammalian development

The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis1

(2016) Daniel W. Serber et al.   BIOLOGY OF REPRODUCTION

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

(2016) Pratik A. Lalit et al.   Cell Stem Cell

7SK-BAF axis controls pervasive transcription at enhancers

(2016) Ryan A Flynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

7SK-BAF axis controls pervasive transcription at enhancers

(2016) Ryan A Flynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First glimpses of the neurobiology of autism spectrum disorder

(2015) Stephan J Sanders   CURRENT OPINION IN GENETICS & DEVELOPMENT

Brg1 modulates enhancer activation in mesoderm lineage commitment

(2015) J. M. Alexander et al.   DEVELOPMENT

Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification

(2015) Aoife O'Shaughnessy-Kirwan et al.   DEVELOPMENT

CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis

(2015) S. Suzuki et al.   DEVELOPMENT

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development

(2015) Sophie Payne et al.   DEVELOPMENTAL BIOLOGY

Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis

(2015) S. Albini et al.   EMBO REPORTS

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor

(2015) Teresita L. Arenzana et al.   GENES & DEVELOPMENT

BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation

(2015) Ienglam Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brg1-Dependent Chromatin Remodelling Is Not Essentially Required during Oligodendroglial Differentiation

(2015) M. Bischof et al.   JOURNAL OF NEUROSCIENCE

Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis

(2015) Ranjan Banerjee et al.   Metabolomics

BRG1 GovernsNanogTranscription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation

(2015) Timothy S. Carey et al.   MOLECULAR AND CELLULAR BIOLOGY

Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification

(2015) Zhuojuan Luo et al.   MOLECULAR CELL

The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex

(2015) Erin Knock et al.   Neural Development

Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription

(2015) Fong Ming Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency

(2015) Tae Wan Kim et al.   STEM CELLS

MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs

(2015) Staton L. Wade et al.   STEM CELLS

Knockdown ofBrmandBaf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells

(2015) Zongliang Jiang et al.   STEM CELLS AND DEVELOPMENT

Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions

(2015) Lee Siggens et al.   Epigenetics & Chromatin

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

(2015) Justin Cotney et al.   Nature Communications

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance

(2015) Duygu Ozmadenci et al.   Nature Communications

Embryonic stem cell differentiation requires full length Chd1

(2015) Paolo Piatti et al.   Scientific Reports

Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a Regulator of Embryonic Stem Cell Differentiation

(2015) Adi Alajem et al.   Cell Reports

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development

(2015) Ramanathan Narayanan et al.   Cell Reports

Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells

(2015) Dana Koludrovic et al.   PLoS Genetics

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

(2015) Patrick Laurette et al.   eLife

SWI/SNF Chromatin-Remodeling Enzymes Brahma-Related Gene 1 (BRG1) and Brahma (BRM) Are Dispensable in Multiple Models of Postnatal Angiogenesis But Are Required for Vascular Integrity in Infant Mice

(2015) M. M. Wiley et al.   Journal of the American Heart Association

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node

(2014) Meng Wu et al.   CELL RESEARCH

INO80 Facilitates Pluripotency Gene Activation in Embryonic Stem Cell Self-Renewal, Reprogramming, and Blastocyst Development

(2014) Li Wang et al.   Cell Stem Cell

myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis

(2014) K. Goljanek-Whysall et al.   DEVELOPMENT

Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast

(2014) M. Guzman-Ayala et al.   DEVELOPMENT

FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development

(2014) Audrey S. Garnatz et al.   DEVELOPMENTAL BIOLOGY

The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal development

(2014) Ethan D. Sperry et al.   DEVELOPMENTAL DYNAMICS

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles

(2014) V. Saccone et al.   GENES & DEVELOPMENT

Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis

(2014) C. Attanasio et al.   GENOME RESEARCH

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

(2014) Tomoko Yamada et al.   NEURON

The mammalian INO80 chromatin remodeling complex is required for replication stress recovery

(2014) Ivelina Vassileva et al.   NUCLEIC ACIDS RESEARCH

BAF200 Is Required for Heart Morphogenesis and Coronary Artery Development

(2014) Lingjuan He et al.   PLoS One

CHD8regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

(2014) Aarathi Sugathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus

(2014) Kieran M. Jones et al.   STEM CELLS

Chd5 orchestrates chromatin remodelling during sperm development

(2014) Wangzhi Li et al.   Nature Communications

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

(2014) Matías Alvarez-Saavedra et al.   Nature Communications

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

(2014) W Patrick Devine et al.   eLife

Transcriptional Repression by the BRG1-SWI/SNF Complex Affects the Pluripotency of Human Embryonic Stem Cells

(2014) Xiaoli Zhang et al.   Stem Cell Reports

The Imitation Switch ATPase Snf2l Is Required for Superovulation and Regulates Fgl2 in Differentiating Mouse Granulosa Cells

(2013) D. Pepin et al.   BIOLOGY OF REPRODUCTION

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

(2013) Yang Yu et al.   CELL

ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4

(2013) Xiaomin Bao et al.   Cell Stem Cell

Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

(2013) Yiqin Xiong et al.   DEVELOPMENTAL CELL

Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness

(2013) Tran Cong Tuoc et al.   DEVELOPMENTAL CELL

CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression

(2013) Chris M. Egan et al.   DEVELOPMENTAL CELL

BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling

(2013) Barbara H Chaiyachati et al.   EMBO JOURNAL

The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain

(2013) Assaf Vestin et al.   GENE EXPRESSION PATTERNS

Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment

(2013) W. Cai et al.   GENES & DEVELOPMENT

CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice

(2013) Yuelong Liu et al.   HUMAN MOLECULAR GENETICS

The BRG1 chromatin remodeler regulates widespread changes in gene expression and cell proliferation during B cell activation

(2013) Darcy Holley et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of SS18 with CREST and Integration with Neural Developmental Pathways

(2013) B. T. Staahl et al.   JOURNAL OF NEUROSCIENCE

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

(2013) John R Prensner et al.   NATURE GENETICS

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory

(2013) Annie Vogel-Ciernia et al.   NATURE NEUROSCIENCE

Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains

(2013) Swetansu K Hota et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SWI/SNF Enzymes Promote SOX10- Mediated Activation of Myelin Gene Expression

(2013) Himangi G. Marathe et al.   PLoS One

Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development

(2013) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex

(2013) L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Reprogramming of Human Embryonic Stem Cells into Skeletal Muscle Cells and Generation of Contractile Myospheres

(2013) Sonia Albini et al.   Cell Reports

Mouse BAZ1A (ACF1) Is Dispensable for Double-Strand Break Repair but Is Essential for Averting Improper Gene Expression during Spermatogenesis

(2013) James A. Dowdle et al.   PLoS Genetics

H2A.Z Acidic Patch Couples Chromatin Dynamics to Regulation of Gene Expression Programs during ESC Differentiation

(2013) Vidya Subramanian et al.   PLoS Genetics

The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function

(2012) V. Krasteva et al.   BLOOD

Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart

(2012) Monte S. Willis et al.   CIRCULATION RESEARCH

Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development

(2012) D.R. Denner et al.   DEVELOPMENTAL BIOLOGY

Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination

(2012) Matthias Weider et al.   DEVELOPMENTAL CELL

Snf2l Regulates Foxg1-Dependent Progenitor Cell Expansion in the Developing Brain

(2012) Darren J. Yip et al.   DEVELOPMENTAL CELL

Mutation update on the CHD7 gene involved in CHARGE syndrome

(2012) Nicole Janssen et al.   HUMAN MUTATION

SWI/SNF Protein Component BAF250a Regulates Cardiac Progenitor Cell Differentiation by Modulating Chromatin Accessibility during Second Heart Field Development

(2012) Ienglam Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development

(2012) J. Choi et al.   JOURNAL OF IMMUNOLOGY

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development

(2012) Stephanie L. Smith-Roe et al.   MAMMALIAN GENOME

Williams Syndrome Transcription Factor is critical for neural crest cell function in Xenopus laevis

(2012) Chris Barnett et al.   MECHANISMS OF DEVELOPMENT

The SnAC Domain of SWI/SNF Is a Histone Anchor Required for Remodeling

(2012) P. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes

(2012) Cedric R. Clapier et al.   NATURE

Phosphorylation of human INO80 is involved in DNA damage tolerance

(2011) Dai Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity

(2011) Manolis Papamichos-Chronakis et al.   CELL

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex

(2011) Sonia V Forcales et al.   EMBO JOURNAL

NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

(2011) Nicola Reynolds et al.   EMBO JOURNAL

Chromatin remodeling complex NURF regulates thymocyte maturation

(2011) J. W. Landry et al.   GENES & DEVELOPMENT

Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene Expression

(2011) Fuhua Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWI/SNF Complexes Containing Brahma or Brahma-Related Gene 1 Play Distinct Roles in Smooth Muscle Development

(2011) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function

(2011) Lena Ho et al.   NATURE CELL BIOLOGY

Chromatin remodelling complex dosage modulates transcription factor function in heart development

(2011) Jun K. Takeuchi et al.   Nature Communications

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations

(2010) J. Krosl et al.   BLOOD

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming

(2010) Nishant Singhal et al.   CELL

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear

(2010) E. A. Hurd et al.   DEVELOPMENT

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation

(2010) Ana Cuadrado et al.   EMBO JOURNAL

Essential Role of p400/mDomino Chromatin-remodeling ATPase in Bone Marrow Hematopoiesis and Cell-cycle Progression

(2010) Toshihiro Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myogenic MicroRNA Expression Requires ATP-Dependent Chromatin Remodeling Enzyme Function

(2010) C. Mallappa et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

CHD7 cooperates with PBAF to control multipotent neural crest formation

(2010) Ruchi Bajpai et al.   NATURE

Chromatin regulation by Brg1 underlies heart muscle development and disease

(2010) Calvin T. Hang et al.   NATURE

Brg1 Is Required for Cdx2-Mediated Repression of Oct4 Expression in Mouse Blastocysts

(2010) Kai Wang et al.   PLoS One

Understanding the Words of Chromatin Regulation

(2009) Jiang I. Wu et al.   CELL

Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex

(2009) Mimi Wan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

(2009) Alexandre Gaspar-Maia et al.   NATURE

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

(2009) Jun K. Takeuchi et al.   NATURE

BRG1 directly regulates nucleosome structure and chromatin looping of the α globin locus to activate transcription

(2009) Shin-Il Kim et al.   NUCLEIC ACIDS RESEARCH

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network

(2009) L. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRG1 requirement for long-range interaction of a locus control region with a downstream promoter

(2009) S.-I. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

(2009) L. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smarcc1/Baf155 Couples Self-Renewal Gene Repression with Changes in Chromatin Structure in Mouse Embryonic Stem Cells

(2009) Christoph Schaniel et al.   STEM CELLS

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

(2008) Menno P. Creyghton et al.   CELL

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

(2008) Thomas G. Fazzio et al.   CELL

Genome-wide Coactivation Analysis of PGC-1α Identifies BAF60a as a Regulator of Hepatic Lipid Metabolism

(2008) Siming Li et al.   Cell Metabolism

Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180

(2008) Xuling Huang et al.   DEVELOPMENTAL BIOLOGY

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

(2008) Kryn Stankunas et al.   DEVELOPMENTAL CELL

BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

(2008) Matthias D. Kaeser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development

(2008) Anant Jani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

(2008) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAF250B-Associated SWI/SNF Chromatin-Remodeling Complex Is Required to Maintain Undifferentiated Mouse Embryonic Stem Cells

(2008) Zhijiang Yan et al.   STEM CELLS

SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells

(2008) Benjamin L. Kidder et al.   STEM CELLS

Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells

(2008) Joseph Landry et al.   PLoS Genetics

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

(2008) Alyson Ashe et al.   GENOME BIOLOGY

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development

(2007) C. T. Griffin et al.   DEVELOPMENT

SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development

(2007) Daehee Han et al.   DEVELOPMENTAL BIOLOGY