Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)

ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4

(2020) Yujing Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Vitexin protects against ethanol-induced liver injury through Sirt1/p53 signaling pathway

(2020) Huiqi Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early life exposure to triphenyl phosphate: Effects on thyroid function, growth, and resting metabolic rate of Japanese quail (Coturnix japonica) chicks

(2019) M.F. Guigueno et al.   ENVIRONMENTAL POLLUTION

Organophosphate flame retardants (OPFRs) induce genotoxicity in vivo: A survey on apoptosis, DNA methylation, DNA oxidative damage, liver metabolites, and transcriptomics

(2019) Rui Chen et al.   ENVIRONMENT INTERNATIONAL

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

(2019) Steffen Boettcher et al.   SCIENCE

Probing the effects of hexavalent chromium exposure on histology and fatty acid metabolism in liver of Bufo gargarizans tadpoles

(2019) Yijie Yang et al.   CHEMOSPHERE

Blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes

(2019) Yujing Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Assessment of the effects of early life exposure to triphenyl phosphate on fear, boldness, aggression, and activity in Japanese quail (Coturnix japonica) chicks

(2019) Ashley K. Hanas et al.   ENVIRONMENTAL POLLUTION

Microbial community evolution of black and stinking rivers during in situ remediation through micro-nano bubble and submerged resin floating bed technology

(2018) Yanmei Sun et al.   BIORESOURCE TECHNOLOGY

From correlation to causation: analysis of metabolomics data using systems biology approaches

(2018) Antonio Rosato et al.   Metabolomics

A Multi-Omics Analysis of Glycine max Leaves Reveals Alteration in Flavonoid and Isoflavonoid Metabolism Upon Ethylene and Abscisic Acid Treatment

(2018) Ravi Gupta et al.   PROTEOMICS

Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae

(2018) Qipeng Shi et al.   AQUATIC TOXICOLOGY

Thioredoxin-like2/2-Cys peroxiredoxin redox cascade supports oxidative thiol modulation in chloroplasts

(2018) Keisuke Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabonomics reveals that triclocarban affects liver metabolism by affecting glucose metabolism, β-oxidation of fatty acids, and the TCA cycle in male mice

(2018) Wentao Li et al.   TOXICOLOGY LETTERS

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

(2018) Ross A. Kelly et al.   PLoS One

Toxicogenomics: A 2020 Vision

(2018) Zhichao Liu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+

(2018) Eligio F. Iannetti et al.   Cell Death & Disease

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Environmentally Relevant Concentrations of the Organophosphorus Flame Retardant Triphenyl Phosphate Impaired Testicular Development and Reproductive Behaviors in Japanese Medaka (Oryzias latipes)

(2018) Yu Li et al.   Environmental Science & Technology Letters

Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish

(2018) Xiaoshan Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of organophosphorus flame retardant TDCPP on normal human corneal epithelial cells: Implications for human health

(2017) Ping Xiang et al.   ENVIRONMENTAL POLLUTION

Occurrence and fate of organophosphate ester flame retardants and plasticizers in indoor air and dust of Nepal: Implication for human exposure

(2017) Ishwar Chandra Yadav et al.   ENVIRONMENTAL POLLUTION

Benzotriazole UV 328 and UV-P showed distinct antiandrogenic activity upon human CYP3A4-mediated biotransformation

(2017) Shulin Zhuang et al.   ENVIRONMENTAL POLLUTION

Organophosphate Esters in Air, Snow, and Seawater in the North Atlantic and the Arctic

(2017) Jing Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Side Chains of Parabens Modulate Antiandrogenic Activity: In Vitro and Molecular Docking Studies

(2017) Keke Ding et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Organophosphate Esters in Sediment of the Great Lakes

(2017) Dandan Cao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

(2017) Xuetian Yue et al.   JOURNAL OF MOLECULAR BIOLOGY

Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai and Yellow Seas, China

(2017) Mingyu Zhong et al.   MARINE POLLUTION BULLETIN

Apurinic/apyrimidinic endonuclease 1 (APE1) contributes to resveratrol-induced neuroprotection against oxygen-glucose deprivation and re-oxygenation injury in HT22 cells: Involvement in reducing oxidative DNA damage

(2017) Jiao-Ying Jia et al.   Molecular Medicine Reports

Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States

(2017) Kate Hoffman et al.   Environmental Science & Technology Letters

Nail polish as a source of exposure to triphenyl phosphate

(2016) Emma Mendelsohn et al.   ENVIRONMENT INTERNATIONAL

Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro , in vivo and in silico approaches

(2016) Quan Zhang et al.   ENVIRONMENTAL POLLUTION

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A

(2016) Kerstin Siegmund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Organophosphorus flame retardants and plasticizers: Sources, occurrence, toxicity and human exposure

(2015) Gao-Ling Wei et al.   ENVIRONMENTAL POLLUTION

Investigating Endocrine and Physiological Parameters of Captive American Kestrels Exposed by Diet to Selected Organophosphate Flame Retardants

(2015) Kimberly J. Fernie et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP)

(2015) Virginia C. Moser et al.   NEUROTOXICOLOGY AND TERATOLOGY

Physical–chemical properties and evaluative fate modelling of ‘emerging’ and ‘novel’ brominated and organophosphorus flame retardants in the indoor and outdoor environment

(2015) Ioannis Liagkouridis et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study

(2015) Fei Li et al.   TOXICOLOGY LETTERS

A Novel Aldo-Keto Reductase (AKR17A1) of Anabaena sp. PCC 7120 Degrades the Rice Field Herbicide Butachlor and Confers Tolerance to Abiotic Stresses in E. coli

(2015) Chhavi Agrawal et al.   PLoS One

p53 as a target for the treatment of cancer

(2014) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

Organophosphate Ester (OPE) Flame Retardants and Plasticizers in the Open Mediterranean and Black Seas Atmosphere

(2014) Javier Castro-Jiménez et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

NMR-based evaluation of the metabolic profile and response to dichloroacetate of human prostate cancer cells

(2014) Mithun Kailavasan et al.   NMR IN BIOMEDICINE

Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model

(2013) Sei Sasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Decabrominated diphenyl ether (BDE-209) and/or BDE-47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis

(2013) Jie Song et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2′,4,4′-tetrabromodiphenyl ether

(2013) Chenglong Ji et al.   Journal of Proteomics

Metabolic responses of HeLa cells to silica nanoparticles by NMR-based metabolomic analyses

(2013) Jianghua Feng et al.   Metabolomics

APE1/Ref-1 prevents oxidative inactivation of ERK for G1-to-S progression following lead acetate exposure

(2013) Yi-Ting Wang et al.   TOXICOLOGY

Human Fetal Hepatocyte Line, L-02, Exhibits Good Liver Function In Vitro and in an Acute Liver Failure Model

(2013) X. Hu et al.   TRANSPLANTATION PROCEEDINGS

Effects of Tris(1,3-dichloro-2-propyl) phosphate and Tris(1-chloropropyl) phosphate on Cytotoxicity and mRNA Expression in Primary Cultures of Avian Hepatocytes and Neuronal Cells

(2012) Doug Crump et al.   TOXICOLOGICAL SCIENCES

The hormesis effect of BDE-47 in HepG2 cells and the potential molecular mechanism

(2012) Liulin Wang et al.   TOXICOLOGY LETTERS

Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro

(2011) Luís Rato et al.   BIOSCIENCE REPORTS

Application of Twisselmann Extraction, SPME, and GC-MS To Assess Input Sources for Organophosphate Esters into Soil

(2011) Ivana Mihajlović et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism

(2011) P. F. Oliveira et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach

(2011) Tim D. Williams et al.   PLoS Computational Biology

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Expression of PGK1 by Prostate Cancer Cells Induces Bone Formation

(2009) Y. Jung et al.   MOLECULAR CANCER RESEARCH

Protein carbonylation in kidney medulla of the spontaneously hypertensive rat

(2009) Raymond Tyther et al.   Proteomics Clinical Applications

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

High-throughput tissue extraction protocol for NMR- and MS-based metabolomics

(2007) Huifeng Wu et al.   ANALYTICAL BIOCHEMISTRY