Article
Chemistry, Applied
Longjia Yan, Dan Li, Yi Le, Ping Dong, Li Liu
Summary: Fluoride detection is crucial for environmental monitoring and disease screening. Small molecule fluorescent probes have gained rapid development in recent years due to their high efficiency, selectivity, and low cost. In this study, a novel phenothiazine-based fluorescent probe PHT was designed and synthesized for the quick detection of fluoride ions. PHT exhibited a response time of only 1 minute and a detection limit of 1.3 ppb. Furthermore, PHT showed a stoke shift of around 140 nm, which surpassed previous reports. Finally, the PHT probe was successfully utilized for HepG2 imaging and detection of biological samples with endemic disease.
Article
Engineering, Environmental
Huachao Che, Xike Tian, Jiahuan Wang, Chu Dai, Yulun Nie, Yong Li, Liqiang Lu
Summary: In order to conveniently and intelligently detect aluminum ions (Al3+) and fluoride ions (F-) in groundwater, a novel organic probe called RBP has been developed. RBP showed significant fluorescence enhancement at 588 nm with the increase of Al3+, and the detection limit was 0.130 mg/L. By combining RBP with fluorescent internal standard CDs, the fluorescence of RBP-Al-CDs at 588 nm was quenched due to the replacement of F- for Al3+, while the CDs at 460 nm remained unchanged, and the detection limit was 0.0186 mg/L. A logic detector based on RBP has been developed for convenient and intelligent detection of Al3+ and F-. It can provide rapid feedback on their concentration levels (U, L and H) within the ultra-trace, low concentration, and high concentration range of Al3+ and F-. The development of the logic detector is of great significance for studying the in-situ chemical behavior of Al3+ and F- and for daily household detection.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Applied
Renjian Hu, Ruoxin Li, Yuanheng Wang, Mengshi Wang, Hongye Huang, Danning Hu, Mei Tian, Zhigang Shuai, Yen Wei
Summary: A novel sensing platform is developed using di-catechol functionalized luminogen cis-DiCat and phenylboronic acid to detect fluoride ions rapidly and quantitatively, with good sensitivity, selectivity, and stability. Ratiometric fluorescence measurements demonstrate a low detection limit of 0.044 mM, meeting the standard suggested by the United States Environmental Protection Agency (EPA). The sensing mechanism is elucidated through both experimental and theoretical approaches.
Article
Chemistry, Applied
Zhenxing Zhang, Xiangtao Kong, Dan Meng, Xiaoyin Zhao, Hua Xie, Weijie Si, Junyan Ma
Summary: In this study, a series of novel fluorescence probes based on a quinolinium scaffold containing fluoride substituted donor were developed. Among them, probe FHyR-3 demonstrated high selectivity, sensitivity, and fast response in detecting hydroxyl radicals due to its extended conjugated system. Furthermore, FHyR-3 exhibited excellent photophysical properties, biocompatibility, and mito-targeting ability.
Article
Spectroscopy
Yongshan Ma, Yanzhao Xia, Xiaodi Wang, Guangxiang Ma, Fengxia Zhang, Tianyi Jiang, Yanyan Zhu, Xuemei Li
Summary: Two novel fluorescent probes (P1 and P2) containing a perylene tetra-(alkoxycarbonyl) derivative (PTAC) and its copper chelate were designed and synthesized. The probes showed high selectivity and sensitivity towards fluoride ions, with their sensing mechanism involving the formation of H-bond between the O-H moiety and fluoride ions. The coordination of copper ion enhanced the H-bond donor capacity of the receptor unit (O-H).
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Heng Shi, Hongjin Chen, Xiangguo Li, Jieni Xing, Gang Zhang, Rui Zhang, Jian Liu
Summary: Two new colorimetric and ratiometric fluoride ion probes, SHJ-1 and SHJ-2, based on the acylhydrazone skeleton have been developed, showing high selectivity and sensitivity towards fluoride ion detection with significant color changes. SHJ-1 exhibited the largest red shift of 145 nm among fluoride ion probes based on acylhydrazone derivatives, indicating strong binding and potential charge transfer transitions.
Article
Biophysics
Zile Zhou, Shengyou Chen, Yinghui Huang, Biao Gu, Jiaqi Li, Cuiyan Wu, Peng Yin, Youyu Zhang, Haitao Li
Summary: A novel copper ion probe was designed to detect Cu2+ accumulation related to AD pathology. The results showed that the content of Cu2+ in the brain tissues of AD mice and drosophila was significantly increased, leading to pathological changes associated with AD.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Yaping Zhang, Yi Qu, Yuqi Zhang, Ya Gao, Le Wang
Summary: In this study, a fluorescent probe (ZYP-1) based on 1,8-naphthalimide was prepared for the detection of fluoride ions, showing high selectivity and sensitivity in real samples. The interaction between the analyte and ZYP-1 was determined through F-19 NMR and H-1 NMR titration, revealing the mechanism of fluorescence enhancement. The probe exhibited a low limit of detection (33 nM) for fluoride ions in acetonitrile, and was successfully applied to detect fluoride in various liquid and solid samples such as food and toothpaste.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Chengyan Wang, Yangsai Lyu, Jia Li, Li Li, Tingting Li, Jie Yang, Ningning Xing, Xiaolei Zhang
Summary: Excessive fluorine poses a serious health threat, and developing a simple and rapid method for detecting and removing excess F- from water is significant but challenging. In this study, a three-dimensional nanoparticle/nanowire hybrid was synthesized as a functional unit for the simultaneous detection and removal of F-. The material exhibited excellent selectivity and sensitivity for F- detection and high capacity for F- removal, providing a strategy for simultaneously selective sensing and efficient removal of anionic pollutants from water.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Applied
Suyu Qiu, Kaizhi Zhang, Tao Zhou, Hui Xu, Jianmin Yu, Xinxin Ban, Fengjie Ge, Dongbao Jia, Qingzheng Zhu, Aiyun Zhu
Summary: A multipolarization branched thermal activated delayed fluorescence sensor, based on cyano-carbazole, was designed and synthesized. The probe showed long fluorescence life, high quantum yield, high selectivity and sensitivity for Fe3+ ions, and a low limit of detection. It also exhibited strong aggregation-induced emission, making it potentially useful for live-cell confocal fluorescence imaging and time-resolved fluorescence imaging.
Article
Chemistry, Analytical
Qiaoyin Li, Haiyan Chen, Shumin You, Zhenyu Lin, Zhitao Chen, Fengping Huang, Bin Qiu
Summary: Proper amount of fluorion is important for human health, but excessive fluorion is harmful. A colorimetric and fluorescence enhanced sensor, using MOF material UiO-66 combined with fluorescent dye FITC, is proposed to detect fluorion with high selectivity. It has a good linear relationship in the range of 2-150 mu M (0.038-2.85 ppm), and has been applied to the detection of actual water samples. Field visual detection of fluoride ion is realized, expanding the application of MOF in fluorescence sensing.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Dan Li, Qin Wang, Nian Rao, Yan Zhang, Yi Le, Li Liu, Luolan Li, Lei Huang, Longjia Yan
Summary: The novel fluorescent probe IMPD based on imidazo[1,2-a]pyridine is designed and synthesized for detection of hydrazine, with maleimide as the recognition group. This probe showed a lower detection limit of 9.1 ppb and could dye HepG2 cells blue in the presence of hydrazine.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Environmental Sciences
Yaoyu Xu, Jiaying Ding, Chengjie Zhang, Mingtao Zhao, Shuaibo Zhu, Guowu Rao, Wen Zhang, Zhenxing Zhang, Junyan Ma
Summary: Hydroxyl radicals are capable of initiating various free radical-induced reactions in natural waters. However, due to their low concentration and short lifetime, quantitative measurement of hydroxyl radicals is insufficient. A novel fluorescence probe has been developed in this study, which exhibits excellent selectivity and enhanced fluorescence for detecting hydroxyl radicals in water systems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Tianze Liu, Lei Wang, Ruxue Jiang, Yashi Tang, Yuxin He, Changze Sun, Yuguang Lv, Shuang Liu
Summary: This paper investigates the fluorescence properties of ZnOQD-GO-g-C3N4 composite materials (ZCGQDs). The addition of a silane coupling agent (APTES) in the synthesis process is explored, and it is found that the addition of 0.04 g/mL APTES results in the highest relative fluorescence intensity and quenching efficiency. The selectivity of ZCGQDs for metal ions, especially Cu2+, is studied, and ZCGQDs show good selectivity. The linear relationship between Cu2+ concentration and ZCGQDs fluorescence intensity in the range of 1 to 100 μM is established, with a detection limit of about 1.74 μM.
Article
Chemistry, Applied
Yan Zhu, Guo-Guo Chen, Zhen-You Zhang, Shi-Li Shen, Yan-Qing Ge, Xiao-Qun Cao, Xian-Hong Pang
Summary: The TEO probe showed high selectivity and sensitivity to CN-, overcoming interference effectively. Both UV and fluorescence titration methods can detect CN- as low as 0.1μM. Moreover, the method was successfully applied to detect amygdalin content in almonds.
Article
Chemistry, Multidisciplinary
Nian Rao, Yi Le, Dan Li, Yan Zhang, Qin Wang, Li Liu, Longjia Yan
Summary: The fluorescent probe PAC, based on phenothiazine, was designed to detect hydrazine with a detection limit of 6.7 ppb. PAC demonstrated AIE properties and naked-eye recognition, with DFT calculations showing good responses to hydrazine. Cell imaging revealed PAC effectively recognized and stained hydrazine in HepG2 cells.
Article
Chemistry, Organic
Qin Wang, Nian Rao, Li Liu, Yi Le, Longjia Yan
Summary: In this paper, a new series of 5-trifluoromethylpyrimidine derivatives were reported for cancer therapy. The compounds were tested for antitumor activity and inhibition of kinases. The results showed that some compounds exhibited good antitumor activity, with compound 6g showing high activity against four cancer cell lines and inhibiting the activity of EGFR and Src.
Article
Chemistry, Applied
Longjia Yan, Dan Li, Yi Le, Ping Dong, Li Liu
Summary: Fluoride detection is crucial for environmental monitoring and disease screening. Small molecule fluorescent probes have gained rapid development in recent years due to their high efficiency, selectivity, and low cost. In this study, a novel phenothiazine-based fluorescent probe PHT was designed and synthesized for the quick detection of fluoride ions. PHT exhibited a response time of only 1 minute and a detection limit of 1.3 ppb. Furthermore, PHT showed a stoke shift of around 140 nm, which surpassed previous reports. Finally, the PHT probe was successfully utilized for HepG2 imaging and detection of biological samples with endemic disease.
Article
Biochemistry & Molecular Biology
Longjia Yan, Qin Wang, Li Liu, Yi Le
Summary: This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. Some of the compounds, especially compound 4c, showed higher anti-tumour activities than Gefitinib and demonstrated potential for development into an anti-tumour drug.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Lei Huang, Zi-Zhen Zhang, Ya-Nan Li, Ping Yi, Wei Gu, Jue Yang, Yan-Mei Li, Xiao-Jiang Hao, Chun-Mao Yuan
Summary: Three unprecedented nor-polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated from Hypericum sampsonii. Their structures were determined through various methods. Compound 1 showed significant inhibition of lipid accumulation in an oleic acid-treated HepG2 cell model.
Article
Chemistry, Multidisciplinary
Dan Li, San Tu, Yi Le, Yue Zhou, Lan Yang, Yuyu Ding, Lei Huang, Li Liu
Summary: This paper introduces the importance of fluorine and the detection method for fluoride ions. A reactive fluorescent probe SCC was designed and synthesized to detect fluoride ions in aqueous systems. The method has high sensitivity and selectivity, and is of great significance for evaluating fluoride pollution in the environment.
Article
Chemistry, Multidisciplinary
Nian Rao, Yuyu Ding, Lan Yang, Yue Zhou, Yi Le, Longjia Yan, Li Liu
Summary: 1,3,5-Triazine derivatives have a wide range of biological and pharmaceutical activities. In this study, a specific triazine derivative was synthesized and characterized, and its crystal structure and biological activity were investigated.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2023)
Article
Spectroscopy
Dan Li, San Tu, Yi Le, Yue Zhou, Lan Yang, Yuyu Ding, Lei Huang, Li Liu
Summary: A reactive fluorescent probe SCP with high quantum yield was designed and synthesized for detection of fluoride ions. The SCP exhibited excellent performance in physiological conditions, including 62.8% quantum yield, good selectivity, and the ability to image HepG2 cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Gui-Li Yang, Lei Huang, Xiao Yang, Zhu Li, Hai-Min Liao, Kang Mao, Zhao-Ju Liu, He-Yan Geng, Qin Cao, Ai-Juan Tan
Summary: In this study, the growth, Cd enrichment, and antioxidant enzyme activity of duckweed were investigated under Cd stress. The results showed that both high-Cd-tolerance duckweed (HCD) and low-Cd-tolerance duckweed (LCD) strains hyper-enriched with Cd. Transcriptome analysis revealed significant differences in gene expression between HCD and LCD, with antioxidant system being significantly expressed in HCD but not in LCD. Alpha-linolenic acid metabolism likely plays an important role in Cd detoxification in duckweed. These findings contribute to the understanding of Cd tolerance mechanisms in hyperaccumulator plants and lay the foundation for future phytoremediation studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Yan Zhang, Zhiwu Long, Nian Rao, Yi Le, Li Liu, Longjia Yan
Summary: A series of new phenylisoxazole derivatives were designed and synthesized for the development of antitumor compounds. The final compounds were characterized through various analytical techniques. The structure and properties of one specific compound (5a) were further confirmed using FT-IR and X-ray single crystal diffraction (XRD). The antitumor activity of all compounds was evaluated against A549 cell using MTT assay.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Rongrong Li, Yan Zhang, Yi Le, Li Liu, Guangju Zhao
Summary: Quinazolone is a heterocyclic scaffold with diverse biological activities, including antidiabetic, antithrombotic, antiviral, antibacterial, and antitumor properties. A new series of quinazolone derivatives, characterized by 1H-NMR, 13C-NMR, HRMS, FT-IR, and X-ray, were designed and synthesized. The density functional theory (DFT) calculation of compound 3f at the B3LYP/6-311 level was also studied. The antitumor activity of all synthesized compounds was evaluated using the MTT assay.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Yuyu Ding, Yan Zhang, Longjia Yan, Li Liu
Summary: Pyrimidine is an essential component of the organism and has significant antibacterial and anticancer properties. A series of pyrimidinothiophene derivatives were synthesized based on the broadly activity of pyrimidine. The structures of the final compounds were analyzed using various techniques, including 1HNMR, 13CNMR, HRMS, single crystal X-ray diffraction, and FT-IR. The intermolecular interactions and contacts of compound 3e were quantified through Hirshfeld surface and 2D fingerprinting analysis. Density functional theory (DFT) calculation and ADMET evaluation were also performed.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemical Research Methods
Tingting Feng, Jiaxue Yang, San Tu, Ting Yang, Ting Wu, Wenqiang Zhu, Yi Le, Li Liu
Summary: In this study, a fluorescent probe was developed and synthesized for the detection of fluoride ions. The probe exhibited high selectivity and sensitivity, and was effective in recognizing fluoride ions within cells.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Multidisciplinary
Yan Zhang, Zhiwu Long, Longjia Yan, Li Liu, Lan Yang, Yi Le
Summary: Polysubstituted phenylisoxazoles were synthesized and found to exhibit improved antibacterial activities, especially the 4-nitro-3-phenylisoxazole derivatives. The compounds showed better inhibitory effects against Xoo, Psa, and Xac compared to the positive control bismerthiazol.
Article
Chemistry, Applied
Leping Chen, Yanfen Wang, Tingyu Shi, Tiantian Ma, Yang Li, Huayu Qiu, Shouchun Yin, Meier Gu
Summary: This study successfully overcame the limitations of the heavy atom effect by introducing iodine atoms and innovatively enhancing the structure while weakening stacking behavior, achieving high efficiency and precision in photodynamic therapy and photothermal therapy.
Article
Chemistry, Applied
Bingpeng Guo, Honghan Sa, Peng Zhang, Guiwen Hao, Mengyu Li, Qingqing Jiang, Baoying Li, Wei Shu, Changxiang Shao
Summary: The design of ratiometric fluorescence probes with large Stokes shift is of great significance in detecting and imaging target substances in complex organisms. In this study, a novel fluorophore with a large Stokes shift was easily obtained, and a fluorescence probe based on it demonstrated rapid response, high selectivity, and sensitivity towards peroxynitrite. The probe also showed excellent biocompatibility and remarkable mitochondrial targeting ability, making it suitable for proportional imaging of peroxynitrite in living cells and zebrafish.
Review
Chemistry, Applied
Haidong Huang, Xiaohui Wang, Xinyang Li, Yichen Li, Guojin Liu, Lan Zhou, Jianzhong Shao
Summary: This article introduces the application of responsive photonic crystals in anti-counterfeiting technology, with a focus on the preparation principle, classification, and preparation methods.
Article
Chemistry, Applied
Yunpeng Wang, Tao Zhao, Xiaoye Bi, Chencheng Lv
Summary: In this study, three novel carbene dyes were designed to achieve environmentally friendly dyeing processes. The dyes formed covalent bonds with fibers and exhibited good dyeing performance and high color fastness. These findings highlight the potential of the novel carbene dyes in promoting green production in the textile industry.
Review
Chemistry, Applied
Yizhe Yan, Xiaopei Zhu, Jia-Xin Cao, Yuan He, Shaoqing Li, Jian-Yong Wang
Summary: In this paper, 1,3,5-triazine dyes were successfully synthesized and their photophysical properties were studied. Two probes were selected for further investigation, showing promising applications in various fields.
Article
Chemistry, Applied
Xin Hu, Tongsheng Huang, Lihua Chen, Weifeng Zhu, Fengjie Deng, Xiancai Li, Jianwen Tian, Meiying Liu, Xiaoyong Zhang, Yen Wei
Summary: This study presents the synthesis of fluorescent cyclomatrix polyphosphazene spheres with aggregation-induced emission (AIE) feature and biodegradable potential for controlled drug delivery. The resulting micelles exhibit high water dispersibility, desirable fluorescence performance, and high drug loading capacity. They can effectively release the encapsulated drug in physiological solution and show excellent biological imaging ability and cytotoxicity against cancer cells.
Article
Chemistry, Applied
Yanzhu Liu, Yanghui Lei, Dongyan Li, Guangkui Li, Dongping Li, Yongxiu Li
Summary: In this study, luminescent lanthanide nanoparticles were synthesized as a dual emission turn-off probe for detecting 2,6-pyridinedicarboxylic acid (DPA) in water. The nanoparticles showed good dispersion and water stability, and achieved low detection limits for DPA. They also exhibited high recoveries in various samples.
Article
Chemistry, Applied
Jung Jae Do, Jong Ryeol Kwon, Donghan Kim, Jae Woong Jung
Summary: This study presents a defect passivation approach using coumarin dye as a multi-functional passivating agent of perovskite films to boost power conversion efficiency and operating stability of PSCs. The incorporation of coumarin dye improves the film morphology, enhances carrier extraction/transport, and suppresses trap-assisted recombination in the perovskite films. The optimized device demonstrates impressive reliability and practical applicability, maintaining over 90% of its initial PCE after being exposed to continuous indoor lighting irradiation for 2000 hours.
Article
Chemistry, Applied
Gang Wang, Yu-Chang Wang, Jing Lu, Wen-Fu Yan, Juan Jin, Yuan-Peng Wang, Jia-Jia Zhang, Hui-Jie Zhang, Hao Dong, Xi-Guang Liu
Summary: A new Ni(II) compound with good solid-state fluorescence performance and stability was synthesized, and it showed outstanding detection properties for various substances in aqueous solutions. This compound has the potential to be a multifunctional sensor.
Article
Chemistry, Applied
Luyao Wei, Shenglong Shang, Yu Zheng, Jie Liu, Ping Zhu
Summary: This study developed a facile method to create high saturation and durable structural colors on cotton fabrics. The colors are regulated by adjusting the size of magnetic particles and can be conveniently printed on fabrics using photo masks on transparent films.
Article
Chemistry, Applied
Zhao Jiang, Qing Zhang, Zhaoyu Kong, Ruijie Qiao, Zichuan Liu, Linzhou Song, Senqiang Zhu, Rui Liu, Hongjun Zhu
Summary: Three heteroleptic Ir(III) complexes with different electron-donating aryl groups were synthesized and their optical properties were investigated. It was found that all three complexes exhibited aggregation-induced phosphorescence emission (AIPE) behaviors, and the relationship between the size of organic ligands and AIPE behaviors was characterized. Ir-PhCz showed the best imaging of latent fingerprints due to its green light emission and high quantum yield.
Article
Chemistry, Applied
Zhijun Ruan, Chunxia Fan, Xuanrong Wang, Dong Shao, Xiaodong Yang, Wentao He, Tao Xu, Junqi Lin, Zhengfang Tian
Summary: A novel thioketal-based probe has been designed for rapid and accurate detection of mercury (II) ions, showing different fluorescence characteristics in various states. The probe exhibits excellent selectivity and specificity, making it suitable for Hg2+ detection in water solutions.
Article
Chemistry, Applied
Jianjun Huang, Xuan Zhao, Daniel Escudero, Luc Van Meervelt, Dongbin Zheng, Yuyu Fang, Wim Dehaen
Summary: A series of BOAHY compounds were successfully synthesized and showed versatile applications as a platform for designing novel fluorescent probes, especially in selective recognition.
Article
Chemistry, Applied
Roman V. Larkovich, Victoria E. Shambalova, Savva A. Ponomarev, Alexander S. Aldoshin, Boris N. Tarasevich, Konstantin A. Lyssenko, Valentine G. Nenajdenko
Summary: An efficient synthetic protocol for the preparation of novel 1,7-difluorinated BODIPYs was elaborated. Their photophysical properties were studied and the effect of 2,6-substituents was evaluated using DFT calculations.
Article
Chemistry, Applied
Haneul Kim, Byungjin Koo
Summary: In this study, a lithium ion sensing methodology based on fluorinated naphthalene compounds using 19F NMR and UV-vis spectroscopy is reported. The binding of lithium ions to the compounds is confirmed by changes in chemical shifts and peak broadening. Additionally, the effect of different crown ether ring sizes on the binding ability is observed. This study provides a new method for lithium ion sensing using spectroscopy.
