Article
Psychiatry
Juliana Mendes Rocha, Giordano Novak Rossi, Flavia L. Osorio, Jose Carlos Bouso Saiz, Gabriela De Oliveira Silveira, Mauricio Yonamine, Eduardo Jose Crevelin, Maria Eugenia Queiroz, Jaime E. Cecilio Hallak, Rafael Guimaraes Dos Santos
Summary: The study examined the effects of ayahuasca on personality in healthy volunteers and found inconsistent results, with a significant increase in Openness scores observed only in one of the trials 21 days post-drug intake. No similar effects were observed in the other trials.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Health Care Sciences & Services
Rafael Guimaraes dos Santos, Jose Carlos Bouso, Juliana Mendes Rocha, Giordano Novak Rossi, Jaime E. Hallak
Summary: Psychedelics act by agonizing serotonergic 5-HT2A receptors, leading to changes in perception, cognitive processes, and mood. Despite historical use in ritual contexts, these substances have gained interest in science and industry for their potential antidepressant, anxiolytic, and antiaddictive effects.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Neurosciences
Danilo De Gregorio, Argel Aguilar-Valles, Katrin H. Preller, Boris Dov Heifets, Meghan Hibicke, Jennifer Mitchell, Gabriella Gobbi
Summary: A resurgence of interest in hallucinogens for the treatment of psychiatric disorders has emerged, with studies confirming the efficacy of ketamine in treating depression. Emerging evidence also suggests potential therapeutic properties of psilocybin, LSD, and MDMA for mental diseases.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Kevin H. Yang, Benjamin H. Han, Joseph J. Palamar
Summary: The study found differences in the association between specific hallucinogens and depression and suicidality. LSD use was associated with an increased likelihood of major depressive episode and suicidal thinking, while salvia divinorum use was associated with suicidal thinking and DMT/AMT/Foxy use was associated with suicidal planning. On the other hand, ecstasy use was associated with a decreased likelihood of serious psychological distress, major depressive episode, and suicidal thinking.
ADDICTIVE BEHAVIORS
(2022)
Review
Psychiatry
Hewa Artin, Sidney Zisook, Dhakshin Ramanathan
Summary: Depression is a common mental disorder that often takes time to treat, leading to the development of novel antidepressants such as ketamine and serotonergic psychedelics. While these new drugs show promising results, their mechanisms of action remain poorly understood.
WORLD JOURNAL OF PSYCHIATRY
(2021)
Review
Biology
Dominika Psiuk, Emilia Nowak, Krystian Cholewa, Urszula Lopuszanska, Marzena Samardakiewicz
Summary: The review summarizes the current knowledge on the safety and efficacy of using psychedelic substances to treat depression. Some psychedelics, especially psilocybin, have been shown to reduce depressive symptoms and have comparable efficacy to escitalopram.
Article
Pharmacology & Pharmacy
Ido Hartogsohn
Summary: This paper explores the formation of psychedelic effects in the context of the Santo Daime religion, emphasizing the profound impact of set and setting on psychedelic effects. The detailed description of the initiation mechanism in the Santo Daime tradition provides a template for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alaina M. Jaster, Mario de la Fuente Revenga, Javier Gonzalez-Maeso
Summary: Psychedelic research is rapidly growing, focusing on exploring the relationship between psychedelic effects and therapeutic manifestations. The serotonin 5-HT2A receptor plays a central role in the distinct effects of psychedelics, with neuropharmacology at the forefront of this debate. The emphasis is on filling knowledge gaps, challenges, and limitations to evaluate the potential antidepressant action of psychedelics.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Health Care Sciences & Services
Lucas Oliveira Maia, Yvan Beaussant, Ana Claudia Mesquita Garcia
Summary: The evaluated evidence suggests positive effects of psychedelic-assisted therapies for symptom control in patients diagnosed with serious illness, especially regarding symptoms of psychological and spiritual nature.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Multidisciplinary Sciences
Grant Jones, Jocelyn A. Ricard, Joshua Lipson, Matthew K. Nock
Summary: Lifetime use of psychedelics, specifically psilocybin mushrooms, may be associated with a lower likelihood of opioid use disorder.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Alan K. Davis, Gabrielle Agin-Liebes, Megan Espana, Brian Pilecki, Jason Luoma
Summary: Psychologists show cautiously positive attitudes towards psychedelic-assisted therapy, but express concerns about potential risks and lack comprehensive understanding of psychedelics. They believe in the potential of psychedelic treatment, endorse the need for further research, and emphasize the importance of increasing education and training about psychedelics to reduce stigma.
JOURNAL OF PSYCHOACTIVE DRUGS
(2022)
Review
Biochemistry & Molecular Biology
Eline Pottie, Christophe P. Stove
Summary: This review focuses on the in vitro molecular techniques used for the characterization of (psychedelic) 5-HT2AR agonists. It covers assays related to G protein signaling pathways, beta-arrestin recruitment or signaling, and receptor conformational changes. The review also discusses variables that should be considered when comparing functional outcomes from different studies.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Substance Abuse
Marek Lukacovic, Radomir Masaryk
Summary: The study aimed to determine the socio-demographic data, preferences, experiences, and attitudes associated with hallucinogen use in Slovakia. Results showed that hallucinogen users in Slovakia have similar trends to users abroad, with males starting at a younger age, using more frequently, and advocating for decriminalization and legalization more than females. Both males and females perceive hallucinogens as beneficial but also risky, with females being more cautious in their use.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Substance Abuse
Patric Plesa, Rotem Petranker
Summary: A psychedelic industrial complex is emerging, with potential benefits and risks yet to be fully understood. Some entrepreneurs have already started marketing psychedelic advice, but there are concerns about exaggerated claims. We propose guidelines for responsible research, therapy, and policy to address these concerns.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Psychiatry
Rita Kocarova, Jiri Horacek, Robin Carhart-Harris
Summary: Addressing global mental health is a major challenge, and new treatments with prophylactic and transdiagnostic effectiveness would represent a significant advance. Psychedelic therapy increases neuronal and mental plasticity, enhancing the potential for change and therapeutic benefits. The combination of psychedelic-induced plasticity with an adequate therapeutic context has prophylactic and transdiagnostic potential, potentially impacting public health positively.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Linda R. Stanley, Randall C. Swaim, Joey K. Smith, Bradley T. Conner
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2020)
Article
Substance Abuse
Theodore Fetterling, Jamie Parnes, Mark A. Prince, Bradley T. Conner, Melissa W. George, Audrey M. Shillington, Nathaniel R. Riggs
Summary: The study found that the Marijuana eCHECKUP TO GO (eCTG) program had a positive impact on reducing cannabis use frequency in both males and females college students, with changes in descriptive norms mediating the intervention effects in males and changes in injunctive norms mediating the effects in females.
SUBSTANCE USE & MISUSE
(2021)
Article
Psychology, Multidisciplinary
Talon P. Flynn, Jamie E. Parnes, Bradley T. Conner
Summary: The study showed a significant relationship between adverse childhood experiences and personality disorder symptoms and health risk behaviors. Childhood resiliency was found to moderate this relationship to some extent.
PSYCHOLOGICAL REPORTS
(2022)
Article
Education & Educational Research
Gemma T. Wallace, Kimberly L. Henry, Karen C. Barrett, Bradley T. Conner
Summary: This study investigated health-risk behaviors among college students and found heterogeneity in engagement. Emotional difficulties were found to be more important for reducing self-injury and suicidality.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Education & Educational Research
Megan G. Weishaar, Shane D. Kentopp, Gemma T. Wallace, Bradley T. Conner
Summary: This study investigates the impact of impulsivity and sensation seeking on extreme sport participation and injury risk. The results identify risk seeking and lack of perseverance as the strongest predictors of extreme sports injury, and risk seeking, experience seeking, and lack of premeditation as the strongest predictors of extreme sports participation.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Criminology & Penology
Shane D. Kentopp, Gereon J. Fredrickson, Megan G. Weishaar, Bradley T. Conner
Summary: This study provides support for the dual systems theory, suggesting that maladaptive behaviors during late adolescence and early adulthood are the result of differential developmental trajectories of a cognitive control system and socioemotional system.
Article
Psychology, Educational
Bradley T. Conner
Summary: The measurement of sensation seeking has been controversial since Zukerman defined it, but the sensation seeking personality trait (SSPT) helps to eliminate psychometric issues and allows researchers to better understand how sensation seeking affects engagement in health risk behaviors.
MEASUREMENT AND EVALUATION IN COUNSELING AND DEVELOPMENT
(2022)
Article
Psychology, Developmental
Bradley T. Conner, Shane D. Kentopp, Maeve B. O'Donnell, Gemma T. Wallace, Jessica L. Morse, Patrice A. Arkfeld, Michael F. Steger, Rachel Rebecca
Summary: Previous research has shown that sensation seeking, emotion dysregulation, and impulsivity are predictive of non-suicidal self-injury (NSSI). However, little research has explored the moderating effects of meaning in life on the relationship between personality and temperament and NSSI. This study found that the presence of meaning in life and the search for meaning in life can serve as protective factors against NSSI in a clinical sample of adolescents. Furthermore, the search for meaning variable was found to moderate the relationship between personality and temperament and NSSI.
JOURNAL OF YOUTH AND ADOLESCENCE
(2022)
Article
Psychology, Multidisciplinary
Morgan L. Sneed, Samuel R. Davis, Theodore J. Fetterling, Mark A. Prince, Aaron M. Eakman, Bradley T. Conner
Summary: This study examined the invariance of cannabis use motives across student service members/veterans and non-veteran students. The results showed metric invariance, indicating that the factor structure and factor loadings of cannabis motives were invariant across groups. However, there were differences in the intercept level among the groups. This has important implications for intervention and treatment planning for both student service members/veterans and non-veteran clients.
MILITARY PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Jamie E. Parnes, Ethan H. Mereish, Samuel N. Meisel, Hayley Treloar Padovano, Robert Miranda Jr
Summary: The purpose of this study was to examine the impact of parental heterosexism on in vivo negative affect and substance craving among sexual minority youth who use nicotine and other substances, and whether this relationship was strengthened in the presence of their parents. The results showed that parental heterosexism was significantly associated with in-the-moment anger, depression, cannabis craving, and alcohol craving. Parental presence was associated with lower odds of reporting anxiety or depression and higher odds of reporting nicotine craving. The findings suggest that parenting behaviors can serve as both protective and risk factors for the negative affect and substance craving of sexual minority youth.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Substance Abuse
Alison Looby, Mark A. Prince, Margo C. Villarosa-Hurlocker, Bradley T. Conner, Ty S. Schepis, Adrian J. Bravo
Summary: The study investigated the co-use of alcohol and marijuana among college students, finding that simultaneous users had higher marijuana use rates and problems compared to dual users. Marijuana-only users did not significantly differ from simultaneous users on marijuana use indices, but reported higher use than dual users.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2021)
Article
Psychology
Mark A. Prince, Bradley T. Conner, Samuel R. Davis, Randall C. Swaim, Linda R. Stanley
Summary: The study utilized Machine Learning algorithm to analyze opioid use among youth, identifying 11 salient risk and protective factors, with highest risk associated with recent cocaine use, trying non-heroin narcotics, and identifying as American Indian. Protective factors included never using opioids other than heroin, infrequent binge drinking, and having fewer friends pressuring drug use.
TRANSLATIONAL ISSUES IN PSYCHOLOGICAL SCIENCE
(2021)
Article
Psychology, Clinical
Mark A. Prince, Alexander J. Tyskiewicz, Bradley T. Conner, Jamie E. Parnes, Audrey M. Shillington, Melissa W. George, Nathaniel R. Riggs
Summary: This study aimed to test the indirect effects of the Marijuana e-CHECKUP TO GO program on frequent marijuana use among college students by examining decreased use in specific social and academic activities. Results showed that the program may be most effective at reducing marijuana use among college students while they are studying.
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2021)
Article
Psychology, Clinical
Gemma T. Wallace, Bradley T. Conner, Audrey M. Shillington
Summary: College students have an elevated risk for self-injurious thoughts and behaviors, with differences in prevalence rates across gender identities. Classification trees are useful in identifying potential risk factors and distinct subpopulations with elevated risk for SITBs. Gender identity plays a significant role in moderating certain risk factors.
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2021)