Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 114, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2020.103831
Keywords
Apoptosis; Broiler; Erythrocyte; Immunity; Protein; Tibial dyschondroplasia
Categories
Funding
- National Key RD Program [2016YFD0500800]
- Shanxi Scholarship Council of China [2017-073]
- Key scientific and technological innovation platform of Jinzhong [P171002-3]
- National Natural Science Foundation of China [31072179]
- Key Technologies R&D Program of Shanxi Province [20130311027-3]
- 131'' Leading Talent Project for Colleges and Universities of Shanxi Province
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Genes related to the Toll-like receptors (TLRs) signaling pathway showed significant differences in expression after being induced by disease, and the rGSTA3 protein was found to prevent chondrocyte death.
The expression of genes related to the Toll-like receptors (TLRs) signaling pathway were determined. Group A, B and C fed with basal diet and group D, E and F induced TD by feeding a basal diet containing 100 mg.kg(-1) thiram. rGSTA3 protein was injected at 20 mu g.kg(-1) in group B, E and at 50 mu g.kg(-1) in C, F. Results suggested that lameness and death of chondrocytes were significant on day 14. TLRs signaling pathway related genes were screened based on the transcriptome enrichment, and validated on qPCR. IL-7, TLR2, 3, 4, 5, 7, 15, MyD88, MHC-II, MDA5 and TRAF6 were significantly (p < 0.05) expressed in group E and F as compared to group D on day 14 and 23. IL-7, MHCII, TRAF6, TLR3, TLR5, TLR7, and TLR15 determined insignificant in group D compared to group A on day 23. TD occur in an early phase and alleviated in the later period. rGSTA3 protein can prevent apoptosis and repair degraded chondrocytes.
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