Review
Oncology
Hongbo Chen, Kai Hou, Jing Yu, Le Wang, Xue Chen
Summary: Melanoma, an increasingly common form of skin cancer, poses challenges due to complications and drug resistance associated with traditional treatments. Combining nanoparticles with conventional methods offers a promising approach by efficiently targeting melanoma cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shahla Bari, Jameel Muzaffar, Zeynep Eroglu
Summary: Activating BRAFV600 mutation accounts for 50% of advanced melanomas. Targeted therapy with BRAF inhibitors has shown impressive responses but resistance remains a challenge. Immunotherapy using immune checkpoint blockers has exhibited durable disease control in BRAF-mutated melanoma patients. Combining targeted therapy with immune therapy may be a promising approach for long-term disease control.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Review
Immunology
Benjamin Wolfson, S. Elizabeth Franks, James W. Hodge
Summary: Effective treatment of established tumors requires rational multicombination immunotherapy strategies designed to target all functions of the patient immune system and tumor immune microenvironment. By combining cancer vaccines with multiple immune agents, such as checkpoint blockade antibodies, novel multifunctional molecules, adoptive cell therapy, and immune system agonists, it is believed that future cancer immunotherapy holds promise for effectively treating established tumors.
Review
Biochemistry & Molecular Biology
Michal Wozniak, Malgorzata Czyz
Summary: Melanoma is a deadly skin cancer that is increasing worldwide. EZH2 mutations have been found in melanoma and contribute to abnormal gene silencing. Recent evidence suggests that targeting the interaction between long non-coding RNAs (lncRNAs) and EZH2 may slow down the progression of melanoma. This review summarizes the involvement of lncRNAs in EZH2-mediated gene silencing in melanoma and discusses the potential of blocking lncRNA-EZH2 interaction as a novel therapeutic option.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Saba S. Shaikh, Yan Zang, Janel Hanmer, Hong Wang, Yan Lin, Diwakar Davar, Hassane M. Zarour, John M. Kirkwood, Yana G. Najjar
Summary: This phase I trial evaluated the safety and efficacy of combined therapy with pembrolizumab, vemurafenib, and cobimetinib in untreated patients with BRAFV600E/K mutant advanced melanoma. The results showed that the triple therapy resulted in prolonged progression-free survival and overall survival, as well as a high objective response rate. However, significant adverse events led to the early closure of the study.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shuai Zhang, Jiaran Zhang, Jun Guo, Lu Si, Xue Bai
Summary: Mucosal melanoma differs from cutaneous melanoma in terms of epidemiology, clinical features, and molecular landscape, and has poorer response to systemic therapy. However, recent advancements in targeted therapy options and combination treatments have provided promising prospects for improving clinical outcomes.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Fengyun Shen, Lele Sun, Lihua Wang, Rui Peng, Chunhai Fan, Zhuang Liu
Summary: This study reported a novel immune adjuvant that can transdermally deliver chemotherapy drugs into melanoma, induce immunogenic death of tumor cells, and trigger systemic tumor-specific immune responses.
Article
Dermatology
Sofia Chilibroste, Amy Monaco, Maria C. Plata, Magdalena Vola, Caroline Agorio, Jose A. Chabalgoity, Maria Moreno
Summary: The treatment of malignant melanoma has improved in recent years with the use of new therapeutic options, but managing advanced disease remains a challenge. In this study, the researchers evaluated the use of LVR01 in combination with dacarbazine as a neoadjuvant therapy for melanoma. They found that this treatment approach could slow tumor growth and prolong overall survival, suggesting a synergistic antitumor effect.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Oncology
Chu Xiao, Tao Fan, Yujia Zheng, He Tian, Ziqin Deng, Jingjing Liu, Chunxiang Li, Jie He
Summary: With the advancements in cancer immunity research, it has been discovered that histone modifications play a crucial role in establishing antitumor immunological ability. Combining epigenetic drugs with immune checkpoint blockades or chimeric antigen receptor-T cell therapies shows promise in improving immunotherapy outcomes. The specific histone modification, H3K4me3, is deeply involved in regulating tumor immunogenicity, reshaping tumor immune microenvironment, and regulating immune cell functions. However, there is still uncertainty in integrating these theoretical foundations and optimizing available therapies. This review explores the mechanisms by which H3K4me3 and its modifiers regulate antitumor immunity and discusses the potential of combining H3K4me3-related agents with immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Regina Krattinger, Egle Ramelyte, Joelle Dornbierer, Reinhard Dummer
Summary: Combination therapy shows great promise in the treatment of resectable and advanced melanoma. Currently, dual immune checkpoint inhibition with nivolumab and ipilimumab is the best first-line treatment option for patients with BRAF-wt and mutated, advanced melanoma. It is recommended for younger patients with good performance status, while monotherapy should be preferred in elderly patients.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberta Cassano, Massimo Cuconato, Gabriella Calviello, Simona Serini, Sonia Trombino
Summary: Melanoma, an aggressive form of skin cancer with limited treatment options, has seen promising developments in nanotechnology as an innovative approach, offering potential for improved survival rates and minimal side effects for patients.
Article
Oncology
Riccardo Marconcini, Paolo Fava, Amedeo Nuzzo, Simona Manacorda, Marco Ferrari, Francesco De Rosa, Michele De Tursi, Enrica Teresa Tanda, Francesca Consoli, Alessandro Minisini, Nicola Pimpinelli, Francesca Morgese, Melissa Bersanelli, Marco Tucci, Maristella Saponara, Alessandro Parisi, Marcella Ocelli, Serena Bazzurri, Giulia Massaro, Riccardo Morganti, Isabella Ciardetti, Ignazio Stanganelli
Summary: In patients with a good prognosis (group A), TT showed statistically significant better PFS than IT, suggesting that TT can be a good first-line option for this patient category. It is only in patients with a poorer prognosis (group B) that we observed a crossing of the survival curves after the 3rd year in favor of IT. Few conclusions can be drawn regarding group C due to the small number of enrolled patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Antonino Guerrisi, Italia Falcone, Fabio Valenti, Marco Rao, Enzo Gallo, Sara Ungania, Maria Teresa Maccallini, Maurizio Fanciulli, Pasquale Frascione, Aldo Morrone, Mauro Caterino
Summary: Artificial intelligence is increasingly being used in the field of medicine, particularly in the treatment of cancer. By processing large amounts of data, AI can assist clinicians in making more accurate treatment decisions, improving patient outcomes.
Editorial Material
Medicine, Research & Experimental
Reinhard Dummer, Michele Welti, Egle Ramelyte
Summary: Novel therapies have achieved unprecedented benefit in survival of advanced melanoma patients. The combination of immunotherapy and targeted therapy shows promise, but more research is needed to determine its superiority over monotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Hanna H. Kakish, Fasih Ali Ahmed, Mohamedraed Elshami, Alexander W. Loftus, Richard S. Hoehn, John B. Ammori, Lee M. Ocuin, Jordan M. Winter, Jeremy S. Bordeaux, Ankit Mangla, Luke D. Rothermel
Summary: In recent years, there has been an increasing focus on clinical trial investment in melanoma therapy, particularly in exploring novel drug mechanisms like immunotherapy and vaccines. Results indicate that ongoing trials may offer new treatment strategies for melanoma patients.
Article
Respiratory System
Ester Simeone, Antonio Maria Grimaldi, Lucia Festino, Claudia Trojaniello, Maria Grazia Vitale, Vito Vanella, Marcello Curvietto, Paolo Antonio Ascierto
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2020)
Review
Oncology
Claudia Trojaniello, Maria Grazia Vitale, Luigi Scarpato, Assunta Esposito, Paolo A. Ascierto
EXPERT REVIEW OF ANTICANCER THERAPY
(2020)
Article
Oncology
Vincenzo Montesarchio, Roberto Parella, Chiara Iommelli, Antonella Bianco, Elio Manzillo, Fiorentino Fraganza, Cristiana Palumbo, Gaetano Rea, Patrizia Murino, Rosanna De Rosa, Luigi Atripaldi, Maurizio D'Abbraccio, Marcello Curvietto, Domenico Mallardo, Egidio Celentano, Antonio Maria Grimaldi, Marco Palla, Claudia Trojaniello, Maria Grazia Vitale, Samuel Lewis Million-Weaver, Paolo Antonio Ascierto
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Prachi Bhave, Lalit Pallan, Georgina V. Long, Alexander M. Menzies, Victoria Atkinson, Justine V. Cohen, Ryan J. Sullivan, Vanna Chiarion-Sileni, Marta Nyakas, Katharina Kahler, Axel Hauschild, Ruth Plummer, Claudia Trojaniello, Paolo A. Ascierto, Lisa Zimmer, Dirk Schadendorf, Clara Allayous, Celeste Lebbe, Andrea Maurichi, Mario Santinami, Severine Roy, Caroline Robert, Thierry Lesimple, Sapna Patel, Judith M. Versluis, Christian U. Blank, Adnan Khattak, Andre van der Westhuizen, Matteo S. Carlino, Mark Shackleton, Andrew Haydon
Summary: The study found that patients who relapse after adjuvant TT respond well to subsequent anti-PD-1 therapy, with outcomes similar to those seen when first-line anti-PD-1 therapy is used in stage IV melanoma.
BRITISH JOURNAL OF CANCER
(2021)
Review
Medicine, Research & Experimental
Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente, Paolo A. Ascierto
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Letter
Oncology
C. Trojaniello, M. G. Vitale, P. A. Ascierto
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Ines Pires da Silva, Tasnia Ahmed, Irene L. M. Reijers, Alison M. Weppler, Allison Betof Warner, James Randall Patrinely, Patricio Serra-Bellver, Clara Allayous, Joanna Mangana, Khang Nguyen, Lisa Zimmer, Claudia Trojaniello, Dan Stout, Megan Lyle, Oliver Klein, Camille L. Gerard, Olivier Michielin, Andrew Haydon, Paolo A. Ascierto, Matteo S. Carlino, Celeste Lebbe, Paul Lorigan, Douglas B. Johnson, Shahneen Sandhu, Serigne N. Lo, Christian U. Blank, Alexander M. Menzies, Georgina V. Long
Summary: The study indicates that for patients resistant to anti-PD-(L)1, ipilimumab plus anti-PD-1 appears to offer higher efficacy compared to ipilimumab monotherapy, with a higher objective response rate, prolonged progression-free survival, longer overall survival, and a similar rate of grade 3-5 toxicity.
Article
Oncology
Valentina Borzillo, Rossella Di Franco, Diana Giannarelli, Fabrizio Cammarota, Esmeralda Scipilliti, Emma D'Ippolito, Angela Petito, Marcello Serra, Sara Falivene, Antonio M. Grimaldi, Ester Simeone, Lucia Festino, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Gabriele Madonna, Paolo A. Ascierto, Paolo Muto
Summary: Combining ipilimumab with stereotactic radiotherapy/radiosurgery could improve local control in patients with melanoma brain metastases. However, the impact and timing of these two methods on patients' outcomes are still unclear.
Article
Oncology
Judith M. Versluis, Anne M. Hendriks, Alison M. Weppler, Lauren J. Brown, Karlijn de Joode, Karijn P. M. Suijkerbuijk, Lisa Zimmer, Ellen W. Kapiteijn, Clara Allayous, Douglas B. Johnson, Adriana Hepner, Joanna Mangana, Prachi Bhave, Yanina J. L. Jansen, Claudia Trojaniello, Victoria Atkinson, Lucy Storey, Paul Lorigan, Paolo A. Ascierto, Bart Neyns, Andrew Haydon, Alexander M. Menzies, Georgina Long, Celeste Lebbe, Astrid A. M. van der Veldt, Matteo S. Carlino, Shahneen Sandhu, Harm van Tinteren, Elisabeth G. E. de Vries, Christian U. Blank, Mathilde Jalving
Summary: Local therapy for solitary progression in melanoma patients who have received immune checkpoint inhibition can lead to favorable long-term outcomes, with almost half of patients showing no subsequent progression.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Claudia Trojaniello, Jason J. Luke, Paolo A. Ascierto
Summary: Melanoma, the most fatal skin cancer, has seen a significant revolution in treatment since 2011 with targeted therapy and immunotherapy. Current research focuses on preventing resistance, increasing drug effectiveness, and exploring new treatment combinations and targets to benefit more patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
T. Troiani, V De Falco, S. Napolitano, C. Trojaniello, P. A. Ascierto
Summary: Cutaneous melanoma is the deadliest form of skin cancer, and the management of locoregional disease has drastically changed in recent years with the introduction of new drugs for locally advanced melanoma that have shown clinical efficacy in adjunctive therapy.
Article
Oncology
Alice Baggi, Pietro Quaglino, Marco Rubatto, Roberta Depenni, Michele Guida, Paolo Antonio Ascierto, Claudia Trojaniello, Paola Queirolo, Maristella Saponara, Ketty Peris, Francesco Spagnolo, Luca Bianchi, Federica De Galitiis, Maria Concetta Potenza, Ilaria Proietti, Riccardo Marconcini, Andrea Botticelli, Vito Barbieri, Lisa Licitra, Salvatore Alfieri, Corrado Ficorella, Alessio Cortellini, Maria Concetta Fargnoli, Teresa Troiani, Luca Tondulli, Paolo Bossi
Summary: A retrospective observational study in Italy evaluated the clinical outcomes of patients with advanced cSCC treated with cemiplimab. The study showed comparable safety and effectiveness results to clinical trials, and identified some clinical and biochemical factors potentially associated with response to cemiplimab.
EUROPEAN JOURNAL OF CANCER
(2021)
Letter
Oncology
Ines Pires da Silva, Tasnia Ahmed, Irene L. M. Reijers, Allison Betof Warner, James Randall Patrinely, Patricio Serra-Bellver, Clara Allayous, Joanna Mangana, Lisa Zimmer, Claudia Trojaniello, Oliver Klein, Camille L. Gerard, Olivier Michielin, Andrew Haydon, Paolo A. Ascierto, Matteo S. Carlino, Celeste Lebbe, Paul Lorigan, Douglas B. Johnson, Shahneen Sandhu, Serigne N. Lo, Alexander M. Menzies, Georgina Long
Meeting Abstract
Oncology
Prachi Bhave, Lalit Pallan, Georgina V. Long, Alexander M. Menzies, Victoria Atkinson, Justine V. Cohen, Ryan J. Sullivan, Vanna Chiarion-Sileni, Marta Nyakas, Katharina Kaehler, Axel Hauschild, Ruth Plummer, Claudia Trojaniello, Paolo A. Ascieto, Lisa Zimmer, Dirk Schadendorf, Clara Allayous, Celeste Lebbe, Andrea Maurichi, Mario Santinami, Severine Roy, Caroline Robert, Thierry Lesimple, Sapna Patel, Judith M. Versluis, Christian U. Blank, Adnan Khattak, Andre van der Westhuizen, Matteo S. Carlino, Mark Shackleton, Andrew Haydon
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2020)