Article
Biochemistry & Molecular Biology
Ashish Kumar Tripathi, Divya Rai, Priyanka Kothari, Pragati Kushwaha, Koneni Sashidhara, Ritu Trivedi
Summary: A compound, 4e, has been identified to have osteogenic potential in glucocorticoid induced osteoporosis (GIOP). Compound 4e preserved osteoblast differentiation and increased the expression of osteogenic genes, resulting in the preservation of bone microarchitecture and cortical thickness. This study is important for the treatment of glucocorticoid-induced osteoporosis.
Article
Pharmacology & Pharmacy
Jing Liu, Xuehui Zheng, Chen Zhang, Chunmei Zhang, Peili Bu
Summary: The study demonstrated that ARNI alleviated myocardial fibrosis by inhibiting the Wnt/beta-catenin signaling pathway and overexpressing sFRP-1, thereby improving cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Naisarg Gamit, Arun Dharmarajan, Gautam Sethi, Sudha Warrier
Summary: Nuclear receptor related 1 (Nurr1) is a transcription factor that regulates midbrain dopaminergic (mDA) neuronal development. Defects in Nurr1 can lead to neurodegeneration and motor function impairment, causing Parkinson's disease (PD). Nurr1 also regulates the expression of alpha-synuclein (alpha-SYN), and mutations in Nurr1 can result in alpha-SYN overexpression, increasing the risk of PD. The Wnt signaling pathway, which plays a role in neurogenesis, modulates Nurr1 and is involved in the downregulation of alpha-SYN. This review explores the interaction between Nurr1 and Wnt signaling pathways in mDA neuronal development, and proposes the modulation of the Wnt pathway as a potential treatment for PD using its antagonist, secreted frizzled related proteins (sFRPs).
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nooralam Rai, Emilio Arteaga-Solis, Monica Goldklang, Tina Zelonina, Jeanine D'Armiento
Summary: Research suggests that the Wnt signaling modulator, SFRP-1, plays a significant role in the development of allergic inflammation in asthma. The study found that SFRP-1 deficiency or inhibition reduced airway inflammation and altered macrophage polarization, indicating its importance in asthma pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Kairan Bao, Yinghua Jiao, Lei Xing, Fang Zhang, Faming Tian
Summary: Osteoporosis, a chronic complication of diabetes mellitus, is caused by chronic hyperglycemia-induced disruption of Wnt signaling pathways. The canonical and non-canonical Wnt signaling pathways play a crucial role in regulating bone homeostasis. This review aims to provide a comprehensive understanding of the effects of abnormal Wnt pathway signaling on bone under hyperglycemia, shedding light on the pathogenesis of diabetic osteoporosis.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biochemistry & Molecular Biology
Federica Mannino, Chiara Imbesi, Natasha Irrera, Giovanni Pallio, Francesco Squadrito, Alessandra Bitto
Summary: This study aimed to investigate whether genistein, a component of soy, could promote osteoblast and osteocyte function during glucocorticoid-induced osteoporosis (GIO) by activating the Wnt/beta-catenin pathway. In an in vitro model of GIO, it was found that genistein reversed the effects of glucocorticoids on osteoblast apoptosis and bone mineralization. This effect was mediated by the activation of estrogen receptors alpha and beta.
Article
Cell & Tissue Engineering
Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: miR-133a is strongly associated with GIO and similar disorders induced by glucocorticoids in MSCs. Silencing miR-133a resulted in positive effects on GC-treated MSCs and on bone loss in GIO animal models. Moreover, the FGFR1-MAPK/ERK signaling may be involved in the protective effect of miR-133a silencing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Margarita M. Ivanova, Julia Dao, Neil Kasaci, Andrew Friedman, Lauren Noll, Ozlem Goker-Alpan
Summary: This study revealed that elevated levels of sclerostin in GD patients are associated with bone pain, BMI, and EM flask deformity. Most patients with elevated sclerostin also have osteopenia. Additionally, sclerostin levels increase with age in GD patients, and are higher compared to healthy controls in the same age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenying Zeng, Shan Wang, Huimin Gu, Fenglei Chen, Ziming Wang, Jinteng Li, Zhongyu Xie, Pei Feng, Huiyong Shen, Yanfeng Wu
Summary: Galangin (GAL) can ameliorate glucocorticoid-induced osteoporosis (GIOP) by augmenting PKA/CREB-mediated autophagic flux, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs).
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Chemistry, Medicinal
Xing Rong, Yuying Kou, Yuan Zhang, Panpan Yang, Rong Tang, Hongrui Liu, Minqi Li
Summary: The study found that ED-71 can prevent glucocorticoid-induced osteoporosis by enhancing osteogenic differentiation, inhibiting osteoclast activity, and modulating the Notch and Wnt/GSK-313/13-catenin signaling pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng, Zhirong Wang
Summary: The research found that activation of dopamine receptor D1R promotes osteogenic differentiation induced by glucocorticoids and reduces bone loss by activating the ERK1/2 signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Baocheng Xie, Huan Zhou, Hongyu Liu, Shiyi Liao, Chenhui Zhou, Daohua Xu
Summary: This study aimed to investigate the protective effect and mechanism of salidroside on dexamethasone-induced osteogenic differentiation and bone formation in MC3T3-E1 cells and zebrafish. The results showed that salidroside had no harmful impact on MC3T3-E1 cells; it significantly relieved dexamethasone-induced inhibition of ALP activity and mineralization in the cells, and promoted osteogenic differentiation. Salidroside alleviated dexamethasone-induced inhibition of osteogenic differentiation and bone formation via TGF-beta /Smad2/3 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Na Chen, Zhanda Fu, Qing Zhang
Summary: Osteoporosis is a serious health disease characterized by bone mass loss, bone density reduction, and degeneration of bone microstructure, leading to bone fragility and a higher risk of fracture. More than 200 million people worldwide suffer from this condition, with estimated treatment costs of at least $25 billion by 2025. The Wnt signaling pathway plays a crucial role in bone development, metabolism, and the differentiation and proliferation of bone-related cells. Inhibitory proteins Dkk-1 and SOST, which block the activation of the canonical Wnt signaling pathway, have potential as targets for osteoporosis treatment. This review provides an analysis of the mechanisms of Wnt proteins, beta-catenin, and signaling molecules, highlighting the importance of the Wnt signaling pathway in osteoporosis and offering new perspectives and approaches for diagnosis and treatment.
Article
Plant Sciences
Yaosheng Xiao, Qun Ren, Yizhou Zheng, Shanshan Zhang, Jing Ouyang, Linhui Jiao, Chunfang Tang, Linfu Li, Weimei Shi, Miaofei Wang, Sainan Zhang, Di Zhang, Bin Zhong, Fang Peng, Zhixi Chen, Longhuo Wu
Summary: The study showed that GEN effectively alleviated the pathological changes of trabecular bone induced by DEX in rats, and reduced the expression levels of ATF4/CHOP. In MC3T3-E1 cells, DEX triggered ER stress and mitochondrial apoptosis, which could be alleviated by inhibiting ER stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Changsheng Yang, Panpan Yang, Peilin Liu, Hong Wang, Ee Ke, Kai Li, Huibo Yan
Summary: This study revealed that FLNA plays a crucial role in osteoporosis by inhibiting osteogenesis and promoting osteoclastogenesis. Inhibiting FLNA and activating the WNT/β-catenin signaling pathway can protect against bone loss in postmenopausal osteoporosis.
CELLULAR SIGNALLING
(2022)